CA2293549C - Composes tricycliques substitues de phenyle servant a inhiber la farnesyl-proteine transferase - Google Patents

Composes tricycliques substitues de phenyle servant a inhiber la farnesyl-proteine transferase Download PDF

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Publication number
CA2293549C
CA2293549C CA002293549A CA2293549A CA2293549C CA 2293549 C CA2293549 C CA 2293549C CA 002293549 A CA002293549 A CA 002293549A CA 2293549 A CA2293549 A CA 2293549A CA 2293549 C CA2293549 C CA 2293549C
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CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
cells
solvate
acceptable salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002293549A
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English (en)
Other versions
CA2293549A1 (fr
Inventor
Adriano Afonso
Joseph M. Kelly
Jay Weinstein
Ronald L. Wolin
Stuart B. Rosenblum
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of CA2293549A1 publication Critical patent/CA2293549A1/fr
Application granted granted Critical
Publication of CA2293549C publication Critical patent/CA2293549C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La présente invention concerne des composés tricycliques à substitution phényle de formule (1.0) et des compositions pharmaceutiques, lesquels sont inhibiteurs de l'enzyme farnésyle protéine transférase. La présente invention concerne également un procédé d'inhibition de la fonction Ras et donc d'inhibition de la croissance anormale des cellules. Le procédé consiste à administrer le nouveau composé d'urée à substitution halo-N à un système biologique. Ce procédé inhibe, en particulier, la croissance anormale des cellules chez des mammifères tel que l'homme.
CA002293549A 1997-06-17 1998-06-15 Composes tricycliques substitues de phenyle servant a inhiber la farnesyl-proteine transferase Expired - Fee Related CA2293549C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87705297A 1997-06-17 1997-06-17
US08/877,052 1997-06-17
PCT/US1998/011509 WO1998057950A1 (fr) 1997-06-17 1998-06-15 Nouveaux composes tricycliques de phenyle substitues inhibiteurs de farnesyl proteine transferase

Publications (2)

Publication Number Publication Date
CA2293549A1 CA2293549A1 (fr) 1998-12-23
CA2293549C true CA2293549C (fr) 2008-08-05

Family

ID=25369151

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002293549A Expired - Fee Related CA2293549C (fr) 1997-06-17 1998-06-15 Composes tricycliques substitues de phenyle servant a inhiber la farnesyl-proteine transferase

Country Status (10)

Country Link
EP (1) EP0989981A1 (fr)
JP (1) JP2002504150A (fr)
KR (1) KR20010013945A (fr)
CN (1) CN1267292A (fr)
AU (1) AU8253798A (fr)
CA (1) CA2293549C (fr)
HU (1) HUP0003215A2 (fr)
IL (1) IL133446A0 (fr)
NZ (1) NZ501613A (fr)
WO (1) WO1998057950A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5939416A (en) 1997-06-17 1999-08-17 Schering Corporation Benzo (5,6) cycloheptapyridine compounds useful as farnesyl protein transferase inhibitors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111235A (en) * 1993-10-15 2001-03-19 Schering Plough Corp Medicinal preparations for inhibiting protein G activity and for the treatment of malignant diseases, containing tricyclic compounds, some such new compounds and a process for the preparation of some of them
CA2174105C (fr) * 1993-10-15 2002-02-12 W. Robert Bishop Composes carbamates tricycliques servant a inhiber la fonction de la proteine g et au traitement de maladies proliferatives
US5719148A (en) * 1993-10-15 1998-02-17 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
IL111257A0 (en) * 1993-10-15 1994-12-29 Schering Corp Tricyclic sulfonamide compounds useful for inhibition of g-protein function and for treatment of proliferative diseases
US5700806A (en) * 1995-03-24 1997-12-23 Schering Corporation Tricyclic amide and urea compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IL125062A (en) * 1995-12-22 2003-11-23 Schering Corp Tricyclic amides and pharmaceutical compositions containing them for inhibition of g-protein function and for treatment of proliferative diseases

Also Published As

Publication number Publication date
AU8253798A (en) 1999-01-04
WO1998057950A1 (fr) 1998-12-23
IL133446A0 (en) 2001-04-30
EP0989981A1 (fr) 2000-04-05
KR20010013945A (ko) 2001-02-26
JP2002504150A (ja) 2002-02-05
CA2293549A1 (fr) 1998-12-23
NZ501613A (en) 2001-11-30
CN1267292A (zh) 2000-09-20
HUP0003215A2 (hu) 2001-06-28

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