CA2294064A1 - Antagonistes du recepteur il-8 - Google Patents
Antagonistes du recepteur il-8 Download PDFInfo
- Publication number
- CA2294064A1 CA2294064A1 CA002294064A CA2294064A CA2294064A1 CA 2294064 A1 CA2294064 A1 CA 2294064A1 CA 002294064 A CA002294064 A CA 002294064A CA 2294064 A CA2294064 A CA 2294064A CA 2294064 A1 CA2294064 A1 CA 2294064A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- alkyl
- heterocyclic
- 4alkyl
- heteroaryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- A—HUMAN NECESSITIES
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Neurosurgery (AREA)
- Hospice & Palliative Care (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Cette invention concerne de nouvelles phénylurées utiles dans le traitement d'états pathologiques induits par la chémokine, Interleukine-8 (IL-8).
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5400197P | 1997-07-29 | 1997-07-29 | |
| US60/054,001 | 1997-07-29 | ||
| PCT/US1998/015830 WO1999006354A1 (fr) | 1997-07-29 | 1998-07-29 | Antagonistes du recepteur il-8 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2294064A1 true CA2294064A1 (fr) | 1999-02-11 |
Family
ID=21988053
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002294064A Abandoned CA2294064A1 (fr) | 1997-07-29 | 1998-07-29 | Antagonistes du recepteur il-8 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1000017A4 (fr) |
| JP (1) | JP2001512096A (fr) |
| AU (1) | AU8673198A (fr) |
| CA (1) | CA2294064A1 (fr) |
| WO (1) | WO1999006354A1 (fr) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2366897C (fr) | 1999-04-06 | 2009-11-17 | Andrew B. Onderdonk | Compositions immunomodulatrices et procedes d'utilisations connexe |
| UY26206A1 (es) * | 1999-06-16 | 2000-12-29 | Smithkline Beecham Plc | Antagonistas del receptor de il-8. |
| FR2801585B1 (fr) | 1999-11-25 | 2002-02-15 | Fournier Ind & Sante | Nouveaux antagonistes des recepteurs de l'ii-8 |
| DE10109204A1 (de) * | 2001-02-26 | 2002-09-19 | 4Sc Ag | Verbindungen zur Behandlung von Protozoen-Erkrankungen |
| US6949567B2 (en) | 2001-02-26 | 2005-09-27 | 4Sc Ag | Compounds for the treatment of protozoal diseases |
| AR041834A1 (es) | 2002-10-29 | 2005-06-01 | Smithkline Beecham Corp | Compuesto de difenilurea sustituido con sulfonamida, composicion farmaceutica que lo comprende y su uso para preparar dicha composicion |
| US7186725B2 (en) | 2003-01-03 | 2007-03-06 | Genzyme Corporation | Anti-inflammatory compositions and methods |
| EP1558582B1 (fr) | 2003-07-22 | 2005-12-21 | Arena Pharmaceuticals, Inc. | Derives de diaryl et arylheteroaryl uree utilises en tant que modulateurs du recepteur de la serotonine 5-ht2a utiles pour la prophylaxie et le traitement de troubles associes a ce dernier |
| CN1926114B (zh) | 2004-03-23 | 2011-08-24 | 艾尼纳制药公司 | 用于制备经取代n-芳基-n′-′3-(1h-吡唑-5-基)苯基脲及其中间体的方法 |
| PE20061130A1 (es) | 2004-11-19 | 2007-01-05 | Arena Pharm Inc | Derivados de 3-fenil-pirazol como moduladores del receptor de serotonina 5-ht2a |
| AU2007240365B2 (en) | 2006-04-21 | 2011-12-15 | Glaxosmithkline Llc | IL-8 receptor antagonists |
| US8097626B2 (en) | 2006-04-21 | 2012-01-17 | Glaxosmithkline Llc | IL-8 receptor antagonists |
| EA016675B1 (ru) | 2006-05-18 | 2012-06-29 | Арена Фармасьютикалз, Инк. | Способы получения фенилпиразолов и кристаллическая форма производного фенилпиразола |
| USRE45336E1 (en) | 2006-05-18 | 2015-01-13 | Arena Pharmaceuticals, Inc. | Primary amines and derivatives thereof as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| WO2007136680A2 (fr) | 2006-05-18 | 2007-11-29 | Arena Pharmaceuticals, Inc. | Éthers, amines secondaires et leurs dérivés utilisés en tant que modulateurs des récepteurs 5-ht2a de la sérotonine et utiles pour traiter les troubles liés à ces récepteurs |
| TWI415845B (zh) | 2006-10-03 | 2013-11-21 | Arena Pharm Inc | 用於治療與５-ｈｔ2ａ血清素受體相關聯病症之作為５-ｈｔ2ａ血清素受體之調節劑的吡唑衍生物 |
| US9567327B2 (en) | 2007-08-15 | 2017-02-14 | Arena Pharmaceuticals, Inc. | Imidazo[1,2-a]pyridine derivatives as modulators of the 5-HT2A serotonin receptor useful for the treatment of disorders related thereto |
| US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
| WO2010062321A1 (fr) | 2008-10-28 | 2010-06-03 | Arena Pharmaceuticals, Inc. | Procédés utiles pour la préparation de 1-[3-(4-bromo-2-méthyl-2h-pyrazol-3-yl)-4-méthoxy-phényl]-3-(2,4-difluoro‑phényl)-urée, et formes cristallines associées |
| TR201805216T4 (en) | 2008-10-28 | 2018-06-21 | Arena Pharm Inc | COMPOSITIONS OF A USEFUL 5-HT2A SEROTONINE RECEPTOR MODULATOR FOR THE TREATMENT OF RELATED DISORDERS |
| WO2011075596A1 (fr) | 2009-12-18 | 2011-06-23 | Arena Pharmaceuticals, Inc. | Formes cristallines de certains dérivés de 3-phényl-pyrazole, modulatrices du récepteur 5-ht2a de la sérotonine, utiles pour le traitement de troubles y étant associés |
| HK1245660A1 (zh) | 2015-06-12 | 2018-08-31 | Axovant Sciences Gmbh | 有用於预防和治疗rem睡眠行为障碍的二芳基脲和芳基脲衍生物 |
| WO2017011767A2 (fr) | 2015-07-15 | 2017-01-19 | Axovant Sciences Ltd. | Dérivés d'arylhérétoaryl urée en tant que modulateurs du récepteur sérotoninergique 5-ht2a utiles pour la prophylaxie et le traitement d'hallucinations associées à une maladie neurodégénérative |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0809492A4 (fr) * | 1995-02-17 | 2007-01-24 | Smithkline Beecham Corp | Antagonistes des recepteurs d'il-8 |
| US5780483A (en) * | 1995-02-17 | 1998-07-14 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
| PL330849A1 (en) * | 1996-06-27 | 1999-06-07 | Smithkline Beecham Corp | Antagonists of il-8 receptors |
-
1998
- 1998-07-29 AU AU86731/98A patent/AU8673198A/en not_active Abandoned
- 1998-07-29 CA CA002294064A patent/CA2294064A1/fr not_active Abandoned
- 1998-07-29 JP JP2000505116A patent/JP2001512096A/ja not_active Withdrawn
- 1998-07-29 EP EP98938138A patent/EP1000017A4/fr not_active Withdrawn
- 1998-07-29 WO PCT/US1998/015830 patent/WO1999006354A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999006354A1 (fr) | 1999-02-11 |
| EP1000017A4 (fr) | 2000-10-18 |
| EP1000017A1 (fr) | 2000-05-17 |
| AU8673198A (en) | 1999-02-22 |
| JP2001512096A (ja) | 2001-08-21 |
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| Date | Code | Title | Description |
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