CA2297909A1 - Antagonistes du recepteur de fibrinogene - Google Patents
Antagonistes du recepteur de fibrinogene Download PDFInfo
- Publication number
- CA2297909A1 CA2297909A1 CA002297909A CA2297909A CA2297909A1 CA 2297909 A1 CA2297909 A1 CA 2297909A1 CA 002297909 A CA002297909 A CA 002297909A CA 2297909 A CA2297909 A CA 2297909A CA 2297909 A1 CA2297909 A1 CA 2297909A1
- Authority
- CA
- Canada
- Prior art keywords
- compound
- acid
- piperazinyl
- pharmaceutically acceptable
- carbonylpiperadino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 229940075507 glyceryl monostearate Drugs 0.000 description 1
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- 239000008187 granular material Substances 0.000 description 1
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- 108010034897 lentil lectin Proteins 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000008176 lyophilized powder Substances 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
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- YICYREKXXVXWCS-UHFFFAOYSA-N methyl 2-bromo-2-(4-methoxyphenyl)acetate Chemical compound COC(=O)C(Br)C1=CC=C(OC)C=C1 YICYREKXXVXWCS-UHFFFAOYSA-N 0.000 description 1
- IEEQWVANVDVFFN-UHFFFAOYSA-N methyl 2-bromo-2-(4-nitrophenyl)acetate Chemical compound COC(=O)C(Br)C1=CC=C([N+]([O-])=O)C=C1 IEEQWVANVDVFFN-UHFFFAOYSA-N 0.000 description 1
- CKDTYRDFEIGXNO-UHFFFAOYSA-N methyl 2-bromo-3-methylbutanoate Chemical compound COC(=O)C(Br)C(C)C CKDTYRDFEIGXNO-UHFFFAOYSA-N 0.000 description 1
- UFQQDNMQADCHGH-UHFFFAOYSA-N methyl 2-bromobutanoate Chemical compound CCC(Br)C(=O)OC UFQQDNMQADCHGH-UHFFFAOYSA-N 0.000 description 1
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- 125000002950 monocyclic group Chemical group 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 1
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- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 1
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- 229940049953 phenylacetate Drugs 0.000 description 1
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
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- 239000000106 platelet aggregation inhibitor Substances 0.000 description 1
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- 229920000656 polylysine Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 238000009258 post-therapy Methods 0.000 description 1
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- 230000003389 potentiating effect Effects 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
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- 150000003180 prostaglandins Chemical class 0.000 description 1
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- 239000003998 snake venom Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000002415 sodium dodecyl sulfate polyacrylamide gel electrophoresis Methods 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 230000009870 specific binding Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 238000013268 sustained release Methods 0.000 description 1
- 239000012730 sustained-release form Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- MGYCIJUTYLUYJM-UHFFFAOYSA-N tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate Chemical compound C1CN(C(=O)OC(C)(C)C)CCN1C1=CC=C([N+]([O-])=O)C=C1 MGYCIJUTYLUYJM-UHFFFAOYSA-N 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- CZDYPVPMEAXLPK-UHFFFAOYSA-N tetramethylsilane Chemical compound C[Si](C)(C)C CZDYPVPMEAXLPK-UHFFFAOYSA-N 0.000 description 1
- 238000004809 thin layer chromatography Methods 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- 229940038773 trisodium citrate Drugs 0.000 description 1
- 108010047303 von Willebrand Factor Proteins 0.000 description 1
- 102100036537 von Willebrand factor Human genes 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne un composé représenté par la formule (I) ou un de ses sels acceptable sur le plan pharmaceutique, servant à inhiber efficacement l'agrégation des plaquettes, des compositions pharmaceutiques permettant de mettre en application cette activité, ainsi qu'un procédé servant à inhiber l'agrégation des plaquettes.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5378897P | 1997-07-25 | 1997-07-25 | |
| US60/053,788 | 1997-07-25 | ||
| US6354597P | 1997-10-28 | 1997-10-28 | |
| US60/063,545 | 1997-10-28 | ||
| PCT/US1998/015288 WO1999004796A1 (fr) | 1997-07-25 | 1998-07-23 | Antagonistes du recepteur de fibrinogene |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2297909A1 true CA2297909A1 (fr) | 1999-02-04 |
Family
ID=26732245
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002297909A Abandoned CA2297909A1 (fr) | 1997-07-25 | 1998-07-23 | Antagonistes du recepteur de fibrinogene |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1001777A4 (fr) |
| JP (1) | JP2002509547A (fr) |
| AU (1) | AU8510398A (fr) |
| CA (1) | CA2297909A1 (fr) |
| CO (1) | CO4970784A1 (fr) |
| WO (1) | WO1999004796A1 (fr) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6069143A (en) * | 1994-12-20 | 2000-05-30 | Smithkline Beecham Corporation | Fibrinogen receptor antagonists |
-
1998
- 1998-07-23 WO PCT/US1998/015288 patent/WO1999004796A1/fr not_active Ceased
- 1998-07-23 CA CA002297909A patent/CA2297909A1/fr not_active Abandoned
- 1998-07-23 JP JP51008299A patent/JP2002509547A/ja active Pending
- 1998-07-23 EP EP98935967A patent/EP1001777A4/fr not_active Withdrawn
- 1998-07-23 AU AU85103/98A patent/AU8510398A/en not_active Abandoned
- 1998-07-24 CO CO98042201A patent/CO4970784A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU8510398A (en) | 1999-02-16 |
| EP1001777A1 (fr) | 2000-05-24 |
| EP1001777A4 (fr) | 2002-10-09 |
| CO4970784A1 (es) | 2000-11-07 |
| JP2002509547A (ja) | 2002-03-26 |
| WO1999004796A1 (fr) | 1999-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |