CA2299619A1 - Nouveau recepteur orphelin - Google Patents

Nouveau recepteur orphelin Download PDF

Info

Publication number
CA2299619A1
CA2299619A1 CA002299619A CA2299619A CA2299619A1 CA 2299619 A1 CA2299619 A1 CA 2299619A1 CA 002299619 A CA002299619 A CA 002299619A CA 2299619 A CA2299619 A CA 2299619A CA 2299619 A1 CA2299619 A1 CA 2299619A1
Authority
CA
Canada
Prior art keywords
ntr
human
human ntr
polypeptide
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002299619A
Other languages
English (en)
Inventor
Piotr J. Masiakowski
Jodi Morris
David M. Valenzuela
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Procter and Gamble Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2299619A1 publication Critical patent/CA2299619A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention porte sur une séquence d'acide nucléique dite HUMAN NTR-1 codant pour un nouveau récepteur orphelin exprimé dans le pancréas et le coeur du foetus. L'invention porte également sur des systèmes d'essai pouvant servir à détecter ou mesurer les ligands se fixant au produit génique HUMAN NTR-1; elle porte en outre sur des procédés thérapeutiques basés sur l'interaction entre le NTR-1 et des agents provoquant la transduction de signaux en se fixant au NTR-1.
CA002299619A 1997-08-06 1998-08-04 Nouveau recepteur orphelin Abandoned CA2299619A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5486997P 1997-08-06 1997-08-06
US60/054,869 1997-08-06
PCT/US1998/016202 WO1999007738A2 (fr) 1997-08-06 1998-08-04 Nouveau recepteur orphelin

Publications (1)

Publication Number Publication Date
CA2299619A1 true CA2299619A1 (fr) 1999-02-18

Family

ID=21994032

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002299619A Abandoned CA2299619A1 (fr) 1997-08-06 1998-08-04 Nouveau recepteur orphelin

Country Status (5)

Country Link
EP (1) EP1019502A2 (fr)
JP (1) JP2001512667A (fr)
AU (1) AU8767698A (fr)
CA (1) CA2299619A1 (fr)
WO (1) WO1999007738A2 (fr)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69837996T2 (de) 1997-01-14 2008-02-28 Human Genome Sciences, Inc. Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
US7285267B2 (en) 1997-01-14 2007-10-23 Human Genome Sciences, Inc. Tumor necrosis factor receptors 6α & 6β
PT1015587E (pt) 1997-09-18 2008-07-31 Genentech Inc Polipéptido dcr3, um homólogo de tnfr
AU1535699A (en) * 1997-11-24 1999-06-15 Apotech S.A. Novel receptors opg-2
JP2002508168A (ja) * 1997-12-16 2002-03-19 インサイト・ファーマスーティカルズ・インコーポレイテッド ヒト腫瘍壊死因子ｒ２様タンパク質
DE19809978A1 (de) * 1998-03-09 1999-09-16 Basf Ag Neuer Rezeptor aus der menschlichen Lunge
IL138626A0 (en) * 1998-03-30 2001-10-31 Lilly Co Eli Therapeutic applications of mature flint (mflint) polypeptides or opg3, a member of the receptor superfamily
WO2000037094A2 (fr) * 1998-12-22 2000-06-29 Eli Lilly And Company Applications therapeutiques de polypeptides flint
DE60041912D1 (de) 1999-02-10 2009-05-14 Serono Genetics Inst Sa Polymorphe marker des lsr-gens
CA2362929A1 (fr) * 1999-03-04 2000-09-08 Human Genome Sciences, Inc. Recepteurs du facteur de necrose tumorale 6 alpha et 6 beta
US6329159B1 (en) * 1999-03-11 2001-12-11 Millennium Pharmaceuticals, Inc. Anti-GPR-9-6 antibodies and methods of identifying agents which modulate GPR-9-6 function
US6965012B1 (en) * 1999-03-30 2005-11-15 Eli Lilly And Company Flint polypeptide analogs
US6627199B1 (en) 1999-07-09 2003-09-30 Amgen Inc Isolation, identification and characterization of tmst2, a novel member of the TNF-receptor supergene family
WO2001010908A1 (fr) 1999-08-04 2001-02-15 Amgen Inc. Ntr3, membre de la famille de supergenes recepteurs du tnf
WO2001011050A1 (fr) 1999-08-04 2001-02-15 Amgen Inc. Fhm, NOUVEAU MEMBRE DE LA FAMILLE DES SUPERGENES LIGANDS DU TNF__
US7338787B2 (en) 2000-01-14 2008-03-04 Serono Genetics Institute S.A. Nucleic acids encoding OBG3 globular head and uses thereof
AU2048501A (en) 2000-02-16 2001-08-27 Genentech Inc. Uses of agonists and antagonists to modulate activity of tnf-related molecules
AU2001247616B2 (en) 2000-04-11 2007-06-14 Genentech, Inc. Multivalent antibodies and uses therefor
ATE415978T1 (de) 2000-07-27 2008-12-15 Genentech Inc Sequentielle verabreichung von cpt-11 und apo-2l polypeptid
PT1409544E (pt) 2001-07-03 2009-09-16 Genentech Inc Anticorpos de dr4 humanos e suas utilizações
US9726673B2 (en) 2005-11-23 2017-08-08 Genentech, Inc. Methods and compositions related to B cell assays

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5447851B1 (en) * 1992-04-02 1999-07-06 Univ Texas System Board Of Dna encoding a chimeric polypeptide comprising the extracellular domain of tnf receptor fused to igg vectors and host cells
US6369027B1 (en) * 1995-12-22 2002-04-09 Amgen Inc. Osteoprotegerin
DE69837996T2 (de) * 1997-01-14 2008-02-28 Human Genome Sciences, Inc. Tumornekrosefaktor-rezeptoren 6 alpha& 6 beta
US5885800A (en) * 1997-02-04 1999-03-23 Smithkline Beecham Corporation DNA encoding tumor necrosis related receptor, TR4

Also Published As

Publication number Publication date
AU8767698A (en) 1999-03-01
JP2001512667A (ja) 2001-08-28
WO1999007738A3 (fr) 1999-04-15
WO1999007738A2 (fr) 1999-02-18
EP1019502A2 (fr) 2000-07-19

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Legal Events

Date Code Title Description
FZDE Discontinued
FZDE Discontinued

Effective date: 20040804