CA2301921A1 - Compositions contenant du polyethylene glycol et leurs utilisations - Google Patents
Compositions contenant du polyethylene glycol et leurs utilisations Download PDFInfo
- Publication number
- CA2301921A1 CA2301921A1 CA002301921A CA2301921A CA2301921A1 CA 2301921 A1 CA2301921 A1 CA 2301921A1 CA 002301921 A CA002301921 A CA 002301921A CA 2301921 A CA2301921 A CA 2301921A CA 2301921 A1 CA2301921 A1 CA 2301921A1
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- Prior art keywords
- peg
- composition
- cells
- based molecule
- peg based
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000000203 mixture Substances 0.000 title claims abstract description 356
- 229920001223 polyethylene glycol Polymers 0.000 title abstract description 241
- 239000002202 Polyethylene glycol Substances 0.000 title abstract description 225
- 238000000034 method Methods 0.000 claims abstract description 205
- 210000004027 cell Anatomy 0.000 claims description 135
- 150000003904 phospholipids Chemical class 0.000 claims description 132
- 210000002216 heart Anatomy 0.000 claims description 78
- 210000000056 organ Anatomy 0.000 claims description 78
- 239000000243 solution Substances 0.000 claims description 68
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims description 66
- -1 polyethylene Polymers 0.000 claims description 64
- 125000000217 alkyl group Chemical group 0.000 claims description 62
- 230000006907 apoptotic process Effects 0.000 claims description 57
- 210000001519 tissue Anatomy 0.000 claims description 52
- 238000011282 treatment Methods 0.000 claims description 50
- 230000010410 reperfusion Effects 0.000 claims description 37
- WRGQSWVCFNIUNZ-GDCKJWNLSA-N 1-oleoyl-sn-glycerol 3-phosphate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](O)COP(O)(O)=O WRGQSWVCFNIUNZ-GDCKJWNLSA-N 0.000 claims description 34
- 208000028867 ischemia Diseases 0.000 claims description 33
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 10
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- 150000003905 phosphatidylinositols Chemical class 0.000 description 13
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- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
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- PORPENFLTBBHSG-MGBGTMOVSA-N 1,2-dihexadecanoyl-sn-glycerol-3-phosphate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(O)=O)OC(=O)CCCCCCCCCCCCCCC PORPENFLTBBHSG-MGBGTMOVSA-N 0.000 description 11
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- UOXRPRZMAROFPH-IESLQMLBSA-N lysophosphatidylinositol Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@@H](O)COP(O)(=O)OC1[C@H](O)[C@@H](O)C(O)[C@@H](O)[C@H]1O UOXRPRZMAROFPH-IESLQMLBSA-N 0.000 description 8
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/12—Chemical aspects of preservation
- A01N1/122—Preservation or perfusion media
- A01N1/125—Freeze protecting agents, e.g. cryoprotectants or osmolarity regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
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- Wood Science & Technology (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La présente invention concerne des compositions thérapeutiques contenant du polyéthylène glycol, des procédés de production des compositions et leurs procédés d'utilisation.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5674497P | 1997-08-20 | 1997-08-20 | |
| US60/056,744 | 1997-08-20 | ||
| PCT/US1998/017258 WO1999008514A1 (fr) | 1997-08-20 | 1998-08-20 | Compositions contenant du polyethylene glycol et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2301921A1 true CA2301921A1 (fr) | 1999-02-25 |
Family
ID=22006334
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002301921A Abandoned CA2301921A1 (fr) | 1997-08-20 | 1998-08-20 | Compositions contenant du polyethylene glycol et leurs utilisations |
Country Status (3)
| Country | Link |
|---|---|
| AU (1) | AU9027298A (fr) |
| CA (1) | CA2301921A1 (fr) |
| WO (1) | WO1999008514A1 (fr) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1069895A4 (fr) * | 1998-03-18 | 2002-07-31 | Lxr Biotechnology Inc | Compositions contenant des acides lysophosphatidiques qui inhibent l'apoptose et leurs utilisations |
| FR2790641B1 (fr) * | 1999-03-10 | 2005-02-25 | Cair L G L | Liquide de conservation de tissu humain ou animal, notamment de veines |
| FR2793651B1 (fr) * | 1999-05-18 | 2003-05-16 | Cair L G L | Solution aqueuse de conservation de tissus et d'organes |
| US6380177B1 (en) | 1999-06-25 | 2002-04-30 | Atairgin Technologies, Inc. | LPA analogs as agonists of the Edg2 LPA receptor |
| AU7057700A (en) * | 1999-08-18 | 2001-03-13 | Atairgin Technologies, Inc. | Compounds which modulate the activity of an lpa receptor |
| CA2402038C (fr) | 2000-03-17 | 2011-03-15 | The University Of Tennessee Research Corporation | Agonistes et antagonistes du recepteur lpa et procedes d'utilisation de ces derniers |
| AU2002352938B8 (en) * | 2002-11-26 | 2009-10-08 | The University Of Chicago | Materials and methods for preventing and treating microbe-mediated epithelial disorders |
| EP1596767B1 (fr) | 2003-02-12 | 2018-10-03 | Syncera, Inc. | Compositions a base d'alliages de polymeres d'oxyde d'alkylene aleatoires et non aleatoires |
| CN1964725A (zh) * | 2004-04-20 | 2007-05-16 | 芝加哥大学 | 包含高分子量peg-样化合物的治疗输送系统 |
| EP2211872A4 (fr) * | 2007-11-02 | 2012-01-04 | Univ British Columbia | Polyglycérol hyperramifié pour améliorer la fonction cardiaque |
| CA2812299C (fr) | 2010-09-23 | 2020-08-04 | Inflammagen, Llc | Administration d'inhibiteurs de la protease serine dans l'estomac |
| US9314442B2 (en) | 2014-03-25 | 2016-04-19 | Leading BioSciences, Inc. | Compositions for the treatment of autodigestion |
| EP3886579B2 (fr) * | 2018-11-30 | 2025-12-24 | iCoat Medical AB | Traitement d'organe ex vivo avec des molécules de peg-phospholipide |
| US11007227B2 (en) | 2019-03-29 | 2021-05-18 | Virginia Commonwealth University | Compositions and methods for restoring or increasing tissue perfusion |
| JP7653164B2 (ja) * | 2019-09-27 | 2025-03-28 | バージニア コモンウェルス ユニバーシティー | 組織を修復または増加させるための組成物および方法 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1986007535A1 (fr) * | 1985-06-20 | 1986-12-31 | Farmacon, Inc. | Complexe pharmaceutique et composition pour empecher la chute descheveux |
| US5525635A (en) * | 1986-02-04 | 1996-06-11 | Moberg; Sven | Pharmaceutical compositions containing propylene glycol and/or polyethylene glycol and urea as active main components and use thereof |
| US5171264A (en) * | 1990-02-28 | 1992-12-15 | Massachusetts Institute Of Technology | Immobilized polyethylene oxide star molecules for bioapplications |
| CA2101361A1 (fr) * | 1992-08-27 | 1994-02-28 | Robert A. Snow | Substances proteiniques a action biologique liees a un oxyde de polyalkylene a faible teneur en diols |
| HRP940645A2 (en) * | 1993-10-06 | 1996-12-31 | Immuno Ag | Process for virus deactivation in the presence of polyalkylene glycol and the pharmaceutical preparation thus obtained |
| US5759548A (en) * | 1993-11-30 | 1998-06-02 | Lxr Biotechnology Inc. | Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof |
| CN1200036A (zh) * | 1995-09-14 | 1998-11-25 | Lxr生物技术有限公司 | 含有磷脂混合物并具有抗细胞程序死亡活性的组合物 |
-
1998
- 1998-08-20 CA CA002301921A patent/CA2301921A1/fr not_active Abandoned
- 1998-08-20 WO PCT/US1998/017258 patent/WO1999008514A1/fr not_active Ceased
- 1998-08-20 AU AU90272/98A patent/AU9027298A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU9027298A (en) | 1999-03-08 |
| WO1999008514A1 (fr) | 1999-02-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |