CA2302036C - Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice - Google Patents
Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice Download PDFInfo
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- CA2302036C CA2302036C CA002302036A CA2302036A CA2302036C CA 2302036 C CA2302036 C CA 2302036C CA 002302036 A CA002302036 A CA 002302036A CA 2302036 A CA2302036 A CA 2302036A CA 2302036 C CA2302036 C CA 2302036C
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Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/10—Ion sources; Ion guns
- H01J49/16—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission
- H01J49/161—Ion sources; Ion guns using surface ionisation, e.g. field-, thermionic- or photo-emission using photoionisation, e.g. by laser
- H01J49/164—Laser desorption/ionisation, e.g. matrix-assisted laser desorption/ionisation [MALDI]
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/02—Details
- H01J49/04—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components
- H01J49/0468—Arrangements for introducing or extracting samples to be analysed, e.g. vacuum locks; Arrangements for external adjustment of electron- or ion-optical components with means for heating or cooling the sample
Landscapes
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Plasma & Fusion (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Abstract
L'invention concerne un procédé de préparation d'échantillons en vue de la réalisation d'analyses de volatilisation et de spectrométrie de masse sur des molécules non volatiles à poids moléculaire élevé. Elle concerne également des molécules photo-absorbantes caractérisées par des vitesses de sublimation importantes à température de la pièce sous vide, lesquelles molécules, qui comportent, de préférence, des valences fonctionnelles hydroxy, sont destinées à être utilisées comme matrices pour la spectrométrie de masse à désorption/ionisation assistée par matrice. Les échantillons sont généralement refroidis dans le spectromètre de masse jusqu'à ce qu'ils atteignent des températures bien inférieures à la température de la pièce.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5093297P | 1997-05-30 | 1997-05-30 | |
| US60/050,932 | 1997-05-30 | ||
| PCT/US1998/011003 WO1998054751A1 (fr) | 1997-05-30 | 1998-05-29 | Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2302036A1 CA2302036A1 (fr) | 1998-12-03 |
| CA2302036C true CA2302036C (fr) | 2003-09-02 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002302036A Expired - Fee Related CA2302036C (fr) | 1997-05-30 | 1998-05-29 | Matrices volatiles pour spectrometrie de masse a desorption/ionisation assistee par matrice |
Country Status (4)
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| EP (1) | EP0998749A1 (fr) |
| AU (1) | AU7804098A (fr) |
| CA (1) | CA2302036C (fr) |
| WO (1) | WO1998054751A1 (fr) |
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|---|---|---|---|---|
| US6436635B1 (en) | 1992-11-06 | 2002-08-20 | Boston University | Solid phase sequencing of double-stranded nucleic acids |
| US5830655A (en) | 1995-05-22 | 1998-11-03 | Sri International | Oligonucleotide sizing using cleavable primers |
| US6133436A (en) | 1996-11-06 | 2000-10-17 | Sequenom, Inc. | Beads bound to a solid support and to nucleic acids |
| EP1164203B1 (fr) | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | Diagnostics de l'ADN fondés sur la spectrométrie de masse |
| EP0963443B1 (fr) | 1996-12-10 | 2006-03-08 | Sequenom, Inc. | Molecules d'etiquetage massique, non volatiles et liberables |
| DE10050632A1 (de) * | 2000-10-12 | 2002-04-18 | Stiftung Caesar | Verfahren zum Nachweis biologischer Moleküle |
| US20030027135A1 (en) | 2001-03-02 | 2003-02-06 | Ecker David J. | Method for rapid detection and identification of bioagents |
| US20040121314A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in containers |
| US20040121309A1 (en) | 2002-12-06 | 2004-06-24 | Ecker David J. | Methods for rapid detection and identification of bioagents in blood, bodily fluids, and bodily tissues |
| US7226739B2 (en) | 2001-03-02 | 2007-06-05 | Isis Pharmaceuticals, Inc | Methods for rapid detection and identification of bioagents in epidemiological and forensic investigations |
| WO2004060278A2 (fr) | 2002-12-06 | 2004-07-22 | Isis Pharmaceuticals, Inc. | Procedes d'identification rapide de pathogenes chez l'homme et les betes |
| US7666588B2 (en) | 2001-03-02 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for rapid forensic analysis of mitochondrial DNA and characterization of mitochondrial DNA heteroplasmy |
| US7217510B2 (en) | 2001-06-26 | 2007-05-15 | Isis Pharmaceuticals, Inc. | Methods for providing bacterial bioagent characterizing information |
| US8158354B2 (en) | 2003-05-13 | 2012-04-17 | Ibis Biosciences, Inc. | Methods for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US7964343B2 (en) | 2003-05-13 | 2011-06-21 | Ibis Biosciences, Inc. | Method for rapid purification of nucleic acids for subsequent analysis by mass spectrometry by solution capture |
| US8242254B2 (en) | 2003-09-11 | 2012-08-14 | Ibis Biosciences, Inc. | Compositions for use in identification of bacteria |
| US8546082B2 (en) | 2003-09-11 | 2013-10-01 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US8097416B2 (en) | 2003-09-11 | 2012-01-17 | Ibis Biosciences, Inc. | Methods for identification of sepsis-causing bacteria |
| US7666592B2 (en) | 2004-02-18 | 2010-02-23 | Ibis Biosciences, Inc. | Methods for concurrent identification and quantification of an unknown bioagent |
| ES2641832T3 (es) | 2004-05-24 | 2017-11-14 | Ibis Biosciences, Inc. | Espectrometría de masas con filtración de iones selectiva por establecimiento de umbrales digitales |
| US20050266411A1 (en) | 2004-05-25 | 2005-12-01 | Hofstadler Steven A | Methods for rapid forensic analysis of mitochondrial DNA |
| US7811753B2 (en) | 2004-07-14 | 2010-10-12 | Ibis Biosciences, Inc. | Methods for repairing degraded DNA |
| WO2006135400A2 (fr) | 2004-08-24 | 2006-12-21 | Isis Pharmaceuticals, Inc. | Procedes pour l'identification rapide d'organismes recombinants |
| US20060205040A1 (en) | 2005-03-03 | 2006-09-14 | Rangarajan Sampath | Compositions for use in identification of adventitious viruses |
| US8084207B2 (en) | 2005-03-03 | 2011-12-27 | Ibis Bioscience, Inc. | Compositions for use in identification of papillomavirus |
| JP2009502137A (ja) | 2005-07-21 | 2009-01-29 | アイシス ファーマシューティカルズ インコーポレイティッド | 核酸変種の迅速な同定および定量のための方法 |
| EP2010679A2 (fr) | 2006-04-06 | 2009-01-07 | Ibis Biosciences, Inc. | Compositions pour l'identification de champignons |
| US9149473B2 (en) | 2006-09-14 | 2015-10-06 | Ibis Biosciences, Inc. | Targeted whole genome amplification method for identification of pathogens |
| EP2126132B1 (fr) | 2007-02-23 | 2013-03-20 | Ibis Biosciences, Inc. | Procédé d'analyse d'adn médico-légale rapide |
| WO2008151023A2 (fr) | 2007-06-01 | 2008-12-11 | Ibis Biosciences, Inc. | Procédés et compositions pour l'amplification par déplacement multiple d'acides nucléiques |
| US8148163B2 (en) | 2008-09-16 | 2012-04-03 | Ibis Biosciences, Inc. | Sample processing units, systems, and related methods |
| WO2010033625A1 (fr) | 2008-09-16 | 2010-03-25 | Ibis Biosciences, Inc. | Systèmes de manipulation de microplaques et produits-programmes informatiques et procédés connexes |
| US8550694B2 (en) | 2008-09-16 | 2013-10-08 | Ibis Biosciences, Inc. | Mixing cartridges, mixing stations, and related kits, systems, and methods |
| WO2010080616A1 (fr) | 2008-12-19 | 2010-07-15 | Abbott Laboratories | Dosage moléculaire pour le diagnostic du paludisme |
| EP2396803A4 (fr) | 2009-02-12 | 2016-10-26 | Ibis Biosciences Inc | Ensembles sonde d'ionisation |
| US9719083B2 (en) | 2009-03-08 | 2017-08-01 | Ibis Biosciences, Inc. | Bioagent detection methods |
| WO2010114842A1 (fr) | 2009-03-30 | 2010-10-07 | Ibis Biosciences, Inc. | Systèmes, dispositifs et procédés de détection d'agent biologique |
| EP2454000A4 (fr) | 2009-07-17 | 2016-08-10 | Ibis Biosciences Inc | Systèmes pour l'identification d'un bioagent |
| US8950604B2 (en) | 2009-07-17 | 2015-02-10 | Ibis Biosciences, Inc. | Lift and mount apparatus |
| WO2011014811A1 (fr) | 2009-07-31 | 2011-02-03 | Ibis Biosciences, Inc. | Amorces de capture et supports solides liés à une séquence de capture pour tests diagnostiques moléculaires |
| EP3098325A1 (fr) | 2009-08-06 | 2016-11-30 | Ibis Biosciences, Inc. | Compositions de base déterminée sans masse pour la détection d'acide nucléique |
| EP2488656B1 (fr) | 2009-10-15 | 2015-06-03 | Ibis Biosciences, Inc. | Amplification par déplacement multiple |
| US9758840B2 (en) | 2010-03-14 | 2017-09-12 | Ibis Biosciences, Inc. | Parasite detection via endosymbiont detection |
| CN116297805A (zh) * | 2023-02-28 | 2023-06-23 | 厦门金诺花生物技术有限公司 | 用于maldi-ms的核酸基质溶液及其制备 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4920264A (en) * | 1989-01-17 | 1990-04-24 | Sri International | Method for preparing samples for mass analysis by desorption from a frozen solution |
| US5118937A (en) * | 1989-08-22 | 1992-06-02 | Finnigan Mat Gmbh | Process and device for the laser desorption of an analyte molecular ions, especially of biomolecules |
| US5135870A (en) * | 1990-06-01 | 1992-08-04 | Arizona Board Of Regents | Laser ablation/ionizaton and mass spectrometric analysis of massive polymers |
| US5700642A (en) * | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
-
1998
- 1998-05-29 CA CA002302036A patent/CA2302036C/fr not_active Expired - Fee Related
- 1998-05-29 WO PCT/US1998/011003 patent/WO1998054751A1/fr not_active Ceased
- 1998-05-29 EP EP98926132A patent/EP0998749A1/fr not_active Withdrawn
- 1998-05-29 AU AU78040/98A patent/AU7804098A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP0998749A1 (fr) | 2000-05-10 |
| AU7804098A (en) | 1998-12-30 |
| CA2302036A1 (fr) | 1998-12-03 |
| WO1998054751A1 (fr) | 1998-12-03 |
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