CA2304093A1 - Hydrogel ameliore pour chirurgie reparatrice - Google Patents

Hydrogel ameliore pour chirurgie reparatrice Download PDF

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Publication number
CA2304093A1
CA2304093A1 CA002304093A CA2304093A CA2304093A1 CA 2304093 A1 CA2304093 A1 CA 2304093A1 CA 002304093 A CA002304093 A CA 002304093A CA 2304093 A CA2304093 A CA 2304093A CA 2304093 A1 CA2304093 A1 CA 2304093A1
Authority
CA
Canada
Prior art keywords
hydrogel
composition
alginate
animal
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002304093A
Other languages
English (en)
Inventor
Kermit M. Borland
Daniel R. Omstead
Tao Zhou
Gordon P. Nelson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US1997/022859 external-priority patent/WO1998025653A2/fr
Application filed by Curis Inc filed Critical Curis Inc
Publication of CA2304093A1 publication Critical patent/CA2304093A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
    • A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L31/145—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des compositions conçues pour être implantées chez l'animal et contenant un polymère biocompatible et biodégradable dont la réticulation crée un hydrogel. Dans un mode de réalisation préféré, ce polymère est réticulé par des ions multivalents, de préférence, par un sel soluble d'un ion multivalent et un sel passablement soluble d'un ion multivalent, ces constituants étant combinés en un mélange constituant un hydrogel injectable partiellement durci, la consistance de ce mélange permettant d'implanter ce dernier chez l'animal, dans lequel il forme in situ un hydrogel totalement durci. Ce mélange contient également, de préférence, un agent séquestrant en concurrence avec le polymère biocompatible afin de fixer l'ion multivalent de réticulation. Cette composition peut contenir des cellules vivantes ou non. Elle concerne également des procédés servant à implanter cette composition chez l'animal sous forme éventuelle d'implant contenant des cellules vivantes.
CA002304093A 1997-09-19 1998-09-18 Hydrogel ameliore pour chirurgie reparatrice Abandoned CA2304093A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US5955897P 1997-09-19 1997-09-19
PCT/US1997/022859 WO1998025653A2 (fr) 1996-12-10 1997-12-10 Hydrogel ameliore pour la creation de tissu
WOPCT/US97/22859 1997-12-10
US60/059,558 1997-12-10
PCT/US1998/019417 WO1999015211A1 (fr) 1997-09-19 1998-09-18 Hydrogel ameliore pour chirurgie reparatrice

Publications (1)

Publication Number Publication Date
CA2304093A1 true CA2304093A1 (fr) 1999-04-01

Family

ID=22023759

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002304093A Abandoned CA2304093A1 (fr) 1997-09-19 1998-09-18 Hydrogel ameliore pour chirurgie reparatrice

Country Status (5)

Country Link
EP (1) EP1015042A1 (fr)
JP (1) JP2001517494A (fr)
AU (1) AU743690B2 (fr)
CA (1) CA2304093A1 (fr)
WO (1) WO1999015211A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8748342B2 (en) 2009-12-08 2014-06-10 Basf Se Pesticidal mixtures

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY130475A (en) 2000-08-25 2007-06-29 Contura As Polyacrylamide hydrogel and its use as an endoprosthesis
US20020114795A1 (en) 2000-12-22 2002-08-22 Thorne Kevin J. Composition and process for bone growth and repair
FR2819814B1 (fr) * 2001-01-22 2004-10-29 Tbf Lab Composition gelifiable biocompatible et implantable
AUPR289601A0 (en) * 2001-02-05 2001-03-01 Commonwealth Scientific And Industrial Research Organisation Method of tissue repair
WO2003002021A2 (fr) 2001-06-29 2003-01-09 The Regents Of The University Of California Implant biodegradable/bioactif de noyau gelatineux et methode de traitement de disques intervertebraux degeneres
WO2003039344A2 (fr) 2001-11-08 2003-05-15 The Regents Of The University Of California Methodes et compositions de correction des troubles de la conduction cardiaque
US7811605B2 (en) 2002-11-06 2010-10-12 Uluru Inc. Method of formation of shape-retentive aggregates of gel particles and their uses
US7351430B2 (en) * 2002-11-06 2008-04-01 Uluru Inc. Shape-retentive hydrogel particle aggregates and their uses
EP1620140B1 (fr) 2003-05-05 2013-10-09 Ben-Gurion University Of The Negev Research And Development Authority Preparations polymeres reticulees injectables et leurs utilisations
AU2005211584B2 (en) * 2003-05-05 2009-01-08 Ben Gurion University Of The Negev Research And Development Authority Injectable Cross-Linked Polymeric Preparations and Uses Thereof
US8073538B2 (en) 2003-11-13 2011-12-06 Cardio Polymers, Inc. Treatment of cardiac arrhythmia by modification of neuronal signaling through fat pads of the heart
ATE486540T1 (de) 2003-12-23 2010-11-15 Fmc Biopolymer As Verwendung von alginat-matrizen zur kontrolle des zellwachstums
WO2005080477A2 (fr) * 2004-02-04 2005-09-01 Cambridge Polymer Group, Inc. Systemes et procedes pour le controle et la formation de gels a base de polymere
MX2007004261A (es) 2004-10-12 2007-06-18 Fmc Biopolymer As Sistemas de alginato auto-gelificantes y usos de los mismos.
US20070048288A1 (en) * 2005-08-30 2007-03-01 Lyu Suping Shear thinning polymer cell delivery compositions
BRPI0714386A2 (pt) * 2006-07-14 2012-12-25 Fmc Biopolymer As hidrogel, conta, mÉtodos para produzir um hidrogel ou uma conta, para implantar uma conta ou dispositivo mÉdico implantÁvel e cÉlulas em um paciente, para bloquear vasos sanguÍneos, e para formar um hidrogel, dispositivo mÉdico implantÁvel, formulaÇço de liberaÇço de droga, agente de contraste ou material radioopaco, e, composiÇço terapÊutica embàlica
US7910135B2 (en) 2006-10-13 2011-03-22 Uluru Inc. Hydrogel wound dressing and biomaterials formed in situ and their uses
JP4740369B2 (ja) 2007-02-21 2011-08-03 持田製薬株式会社 軟骨疾患治療用組成物
WO2008121422A2 (fr) * 2007-04-01 2008-10-09 Moma Therapeutics Composition de matrice de cellules implantable pour la délivrance de composés bioactifs
JP5161482B2 (ja) * 2007-05-09 2013-03-13 オリンパス株式会社 生体組織補填材の製造方法
CN101918007B (zh) 2007-08-28 2014-06-04 Fmc有限公司 延迟的自胶凝藻酸盐体系及其应用
US8367637B2 (en) 2008-08-19 2013-02-05 Mochida Pharmaceutical Co., Ltd. Composition for treating arthritic disorder
US20100111919A1 (en) * 2008-10-31 2010-05-06 Tyco Healthcare Group Lp Delayed gelation compositions and methods of use
US8676319B2 (en) 2010-10-29 2014-03-18 Medtronic, Inc. Implantable medical device with compressible fixation member
WO2013096788A1 (fr) * 2011-12-21 2013-06-27 Ikaria Development Subsidiary One Llc Procédé pour la fabrication de solution d'alginate partiellement réticulé
EP3435975B1 (fr) * 2016-04-01 2021-09-15 Boston Scientific Scimed, Inc. Composition injectable et procès de préparation et son utilisation
JP7272608B2 (ja) 2018-01-18 2023-05-12 ハーイグレク２セーアーエルエー ベスローテン フェンノートシャップ 選択される生物分子のバイオアベイラビリティを低減させるための多孔性親和性ヒドロゲル粒子
CN117731600A (zh) * 2018-02-09 2024-03-22 波士顿科学国际有限公司 凝胶组合物及其制备和用途
CN112969479A (zh) * 2018-11-06 2021-06-15 国立癌症中心 海藻酸基注射型凝胶体系
US12133893B2 (en) 2020-08-24 2024-11-05 The Board Of Trustees Of The Leland Stanford Junior University In-situ stable injectable collagen-based hydrogels for cell and growth factor delivery
CN114748689B (zh) * 2022-04-14 2023-09-15 华南理工大学 一种乳腺重建植入假体水凝胶材料及其制备方法与应用
CN116807520A (zh) * 2023-06-28 2023-09-29 南方医科大学 一种无损无痛微创提取组织液的方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
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DE4103876C2 (de) * 1990-02-09 1994-07-07 Asahi Optical Co Ltd Verfahren zur Fixierung einer körnigen Knochen-Prothese und Kit zur Herstellung einer körnigen Knochen-Prothesezusammensetzung zur Verwendung in dem Fixierungsverfahren
NO171069C (no) * 1990-05-29 1993-01-20 Protan Biopolymer As Kovalent tverrbundne, sterkt svellende alkalimetall- og ammonium-alginatgeler, samt fremgangsmaate for fremstilling derav
US5709854A (en) * 1993-04-30 1998-01-20 Massachusetts Institute Of Technology Tissue formation by injecting a cell-polymeric solution that gels in vivo
US5876742A (en) * 1994-01-24 1999-03-02 The Regents Of The University Of California Biological tissue transplant coated with stabilized multilayer alginate coating suitable for transplantation and method of preparation thereof
US5658329A (en) * 1995-02-14 1997-08-19 Mentor Corporation Filling material for soft tissue implant prostheses and implants made therewith
US6129761A (en) * 1995-06-07 2000-10-10 Reprogenesis, Inc. Injectable hydrogel compositions
AU1051597A (en) * 1995-11-09 1997-05-29 University Of Massachusetts Tissue re-surfacing with hydrogel-cell compositions
GB2320502B (en) * 1996-12-20 2000-09-20 Johnson & Johnson Medical Bioresorbable alginate derivatives
GB9704749D0 (en) * 1997-03-07 1997-04-23 Univ London Tissue Implant

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8748342B2 (en) 2009-12-08 2014-06-10 Basf Se Pesticidal mixtures
US9049859B2 (en) 2009-12-08 2015-06-09 Basf Se Pesticidal mixtures
US9585391B2 (en) 2009-12-08 2017-03-07 Basf Se Pesticidal mixtures

Also Published As

Publication number Publication date
AU743690B2 (en) 2002-01-31
WO1999015211A1 (fr) 1999-04-01
EP1015042A1 (fr) 2000-07-05
JP2001517494A (ja) 2001-10-09
AU9490898A (en) 1999-04-12

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued