CA2304461C - Complexes metalliques lipophiles pour imagerie de necrose ou d'infarcissement - Google Patents

Complexes metalliques lipophiles pour imagerie de necrose ou d'infarcissement Download PDF

Info

Publication number
CA2304461C
CA2304461C CA002304461A CA2304461A CA2304461C CA 2304461 C CA2304461 C CA 2304461C CA 002304461 A CA002304461 A CA 002304461A CA 2304461 A CA2304461 A CA 2304461A CA 2304461 C CA2304461 C CA 2304461C
Authority
CA
Canada
Prior art keywords
carboxymethyl
complex
tris
triazaundecane
necrosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002304461A
Other languages
English (en)
Other versions
CA2304461A1 (fr
Inventor
Johannes Platzek
Ulrich Speck
Ulrich Niedballa
Bernd Raduchel
Hanns-Joachim Weinmann
Wolfgang Ebert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Publication of CA2304461A1 publication Critical patent/CA2304461A1/fr
Application granted granted Critical
Publication of CA2304461C publication Critical patent/CA2304461C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne l'utilisation de complexes métalliques, présentant une liaison aux protéines plasmatiques d'au moins 10 %, comme agents de diagnostic par imagerie, pour localiser un infarctus ou une nécrose au moyen d'une représentation positive persistante.
CA002304461A 1997-09-26 1998-08-17 Complexes metalliques lipophiles pour imagerie de necrose ou d'infarcissement Expired - Fee Related CA2304461C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19744004.5 1997-09-26
DE1997144004 DE19744004C1 (de) 1997-09-26 1997-09-26 Lipophile Metall-Komplexe für Nekrose und Infarkt-Imaging
PCT/EP1998/005185 WO1999016474A1 (fr) 1997-09-26 1998-08-17 Complexes metalliques lipophiles pour necroses et imagerie de l'infarctus

Publications (2)

Publication Number Publication Date
CA2304461A1 CA2304461A1 (fr) 1999-04-08
CA2304461C true CA2304461C (fr) 2008-10-14

Family

ID=7844677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002304461A Expired - Fee Related CA2304461C (fr) 1997-09-26 1998-08-17 Complexes metalliques lipophiles pour imagerie de necrose ou d'infarcissement

Country Status (7)

Country Link
EP (1) EP1017424A1 (fr)
JP (1) JP2001518454A (fr)
AU (1) AU9262898A (fr)
CA (1) CA2304461C (fr)
DE (1) DE19744004C1 (fr)
NO (1) NO321235B1 (fr)
WO (1) WO1999016474A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL146126A0 (en) 1999-04-30 2002-07-25 Slil Biomedical Corp Novel polyamine analog conjugates and quinone conjugates as therapies for cancers and prostate diseases
US6482943B1 (en) 1999-04-30 2002-11-19 Slil Biomedical Corporation Quinones as disease therapies
US7312244B2 (en) 1999-04-30 2007-12-25 Cellgate, Inc. Polyamine analog-amino acid conjugates useful as anticancer agents
TW462515U (en) * 1999-08-04 2001-11-01 Chiang Li Network perfume device
DE10040381C1 (de) * 2000-08-11 2002-06-06 Schering Ag Perfluoralkylhaltige Komplexe mit Zuckerresten, Verfahren zu deren Herstellung und ihre Verwendung
DE10040858C2 (de) * 2000-08-11 2003-12-18 Schering Ag Perfluoralkylhaltige Komplexe mit polaren Resten, Verfahren zu deren Herstellung und ihre Verwendung
DE102005033903B4 (de) * 2005-07-15 2007-08-09 Bayer Schering Pharma Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102005033902B3 (de) * 2005-07-15 2007-04-05 Schering Ag Perfluoralkylhaltige Komplexe, Verfahren zu deren Herstellung, sowie deren Verwendung und diese enthaltende pharmazeutische Mittel
DE102006049821A1 (de) 2006-10-18 2008-04-24 Bayer Schering Pharma Aktiengesellschaft Metallchelate mit perfluoriertem PEG-Rest, Verfahren zu deren Herstellung, sowie deren Verwendung

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4899755A (en) * 1985-05-08 1990-02-13 The General Hospital Corporation Hepatobiliary NMR contrast agents
IT1213029B (it) * 1986-01-30 1989-12-07 Bracco Ind Chimica Spa Chelati di ioni metallici paramagnetici.
IT1224416B (it) * 1987-12-24 1990-10-04 Bracco Ind Chimica Spa Chelanti macrociclici e loro chelati
US5457183A (en) * 1989-03-06 1995-10-10 Board Of Regents, The University Of Texas System Hydroxylated texaphyrins
DE3922005A1 (de) * 1989-06-30 1991-01-10 Schering Ag Derivatisierte dtpa-komplexe, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung
WO1994001393A1 (fr) * 1992-07-03 1994-01-20 The Green Cross Corporation Nouveau chelateur, complexe compose dudit chelateur et d'un atome metallique, et agent diagnostique renfermant ledit complexe
US5358704A (en) * 1993-09-30 1994-10-25 Bristol-Myers Squibb Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
EP0758907A1 (fr) * 1994-05-11 1997-02-26 Schering Aktiengesellschaft Utilisation de composes a base d'un complexe de porphyrine ou d'un complexe de porphyrine etendue comme preparation diagnostique pour la localisation d'un infarctus
TW319763B (fr) * 1995-02-01 1997-11-11 Epix Medical Inc
DE19603033A1 (de) * 1996-01-19 1997-07-24 Schering Ag Perfluoralkylhaltige Metallkomplexe, Verfahren zu deren Herstellung und ihre Verwendung in der NMR-Diagnostik
WO1997030734A1 (fr) * 1996-02-21 1997-08-28 Mallinckrodt Medical, Inc. Agents utilises en resonance magnetique sur le pool sanguin
AU4753997A (en) * 1996-10-16 1998-05-11 Burnham Institute, The Magnetic resonance imaging of thrombi

Also Published As

Publication number Publication date
DE19744004C1 (de) 1999-07-22
JP2001518454A (ja) 2001-10-16
NO321235B1 (no) 2006-04-10
CA2304461A1 (fr) 1999-04-08
NO20001520L (no) 2000-05-25
AU9262898A (en) 1999-04-23
NO20001520D0 (no) 2000-03-23
EP1017424A1 (fr) 2000-07-12
WO1999016474A1 (fr) 1999-04-08

Similar Documents

Publication Publication Date Title
EP0222886B2 (fr) Agents de contraste hepatobiliaire pour resonance magnetique nucleaure
EP0414700B1 (fr) Ameliorations apportees a l'imagerie par resonance magnetique
US5869023A (en) Composition for MRI comprising both a positive and a negative contrast agent
SK4842000A3 (en) Contrast-enhanced diagnostic imaging method for monitoring interventional therapies
CA2108362A1 (fr) Agents a base de melamine pour ameliorer la qualite des images
CA2304461C (fr) Complexes metalliques lipophiles pour imagerie de necrose ou d'infarcissement
AU754294B2 (en) Manganese compositions and methods for MRI
Roberts et al. MRI of acute myocardial ischemia: Comparing a new contrast agent, Gd‐DTPA‐24‐cascade‐polymer, with Gd‐DTPA
US5169944A (en) Methods and compositions for the enteral administration of hepatobiliary MRI contrast agents
Carr Magnetic resonance contrast agents for neuroimaging: safety issues
US6146615A (en) Contrast agents for image enhancement in magnetic resonance imaging
US6495118B1 (en) Lipophilic metal complexes for necrosis and infarction imaging
JP4614281B2 (ja) 磁気共鳴撮像方法並びに該方法に用いられる化合物
AU675013B2 (en) Second sphere complexes as relaxation agents for image enhancement in magnetic resonance imaging
US5716598A (en) Contrast medium for magnetic resonance imaging using physiologically tolerable manganese compound
Goldstein et al. Contrast media for magnetic resonance imaging
JPS60252429A (ja) Ｎｍｒイメージング用造影剤
MXPA01004429A (en) Manganese compositions and methods for mri
HK1000311B (en) Hepatobiliary nmr contrast agents

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed