CA2304484A1 - Procede servant a effectuer le controle selectif de la presence d'une proteine de membrane et de la secretion de proteines dans des cellules eucaryotes - Google Patents
Procede servant a effectuer le controle selectif de la presence d'une proteine de membrane et de la secretion de proteines dans des cellules eucaryotes Download PDFInfo
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- CA2304484A1 CA2304484A1 CA002304484A CA2304484A CA2304484A1 CA 2304484 A1 CA2304484 A1 CA 2304484A1 CA 002304484 A CA002304484 A CA 002304484A CA 2304484 A CA2304484 A CA 2304484A CA 2304484 A1 CA2304484 A1 CA 2304484A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procédé et compositions correspondantes modulant la présence sur une membrane de surface cellulaire de protéines de membrane entières sélectionnées ou la sécrétion de protéines sécrétrices sélectionnées, ce qui consiste à augmenter ou à diminuer le transport intracellulaire de la protéine depuis le réticulum endoplasmique vers et à travers l'appareil de cis-Golgi. Des procédés associés permettent d'identifier si le transport intracellulaire d'une protéine spécifique a pour médiateur le système de trafic de protéines d'adaptation de spectrine et ankyrine (SAATS). Des procédés correspondants servent à déterminer si un composé candidat inhibe ou augmente le transport intracellulaire d'une protéine sélectionnée depuis le réticulum endoplasmique vers l'appareil de cis-Golgi par SAATS. Des agents et des procédés peuvent être mis en application dans une variété de domaines, y compris en tant qu'immunorégulateurs, inhibiteurs de transport d'ions, modulateurs vasculaires et agents chimiothérapeutiques contre le cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6055997P | 1997-09-30 | 1997-09-30 | |
| US60/060,559 | 1997-09-30 | ||
| PCT/US1998/020364 WO1999016875A1 (fr) | 1997-09-30 | 1998-09-30 | Procede servant a effectuer le controle selectif de la presence d'une proteine de membrane et de la secretion de proteines dans des cellules eucaryotes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2304484A1 true CA2304484A1 (fr) | 1999-04-08 |
Family
ID=22030279
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002304484A Abandoned CA2304484A1 (fr) | 1997-09-30 | 1998-09-30 | Procede servant a effectuer le controle selectif de la presence d'une proteine de membrane et de la secretion de proteines dans des cellules eucaryotes |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1021539A4 (fr) |
| JP (1) | JP2001518295A (fr) |
| AU (1) | AU750395B2 (fr) |
| CA (1) | CA2304484A1 (fr) |
| WO (1) | WO1999016875A1 (fr) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002002610A2 (fr) * | 2000-06-29 | 2002-01-10 | Incyte Genomics, Inc. | Molecules de circulation et de secretion |
| GB0121084D0 (en) * | 2001-08-31 | 2001-10-24 | Univ Leeds | Improved productivity of heterologous gene expression |
| US7425426B2 (en) * | 2004-03-15 | 2008-09-16 | Cyntellect, Inc. | Methods for purification of cells based on product secretion |
| JP2012514981A (ja) | 2009-01-12 | 2012-07-05 | イントレクソン コーポレイション | 細胞コロニーのレーザーを介在したセクション化及び移行 |
-
1998
- 1998-09-30 CA CA002304484A patent/CA2304484A1/fr not_active Abandoned
- 1998-09-30 JP JP2000513945A patent/JP2001518295A/ja active Pending
- 1998-09-30 WO PCT/US1998/020364 patent/WO1999016875A1/fr not_active Ceased
- 1998-09-30 AU AU10635/99A patent/AU750395B2/en not_active Ceased
- 1998-09-30 EP EP98953207A patent/EP1021539A4/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU1063599A (en) | 1999-04-23 |
| EP1021539A4 (fr) | 2004-09-29 |
| AU750395B2 (en) | 2002-07-18 |
| EP1021539A1 (fr) | 2000-07-26 |
| JP2001518295A (ja) | 2001-10-16 |
| WO1999016875A1 (fr) | 1999-04-08 |
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