CA2305312C - Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale - Google Patents

Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale Download PDF

Info

Publication number
CA2305312C
CA2305312C CA2305312A CA2305312A CA2305312C CA 2305312 C CA2305312 C CA 2305312C CA 2305312 A CA2305312 A CA 2305312A CA 2305312 A CA2305312 A CA 2305312A CA 2305312 C CA2305312 C CA 2305312C
Authority
CA
Canada
Prior art keywords
seq
gene
nucleic acid
cell
dna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2305312A
Other languages
English (en)
Other versions
CA2305312A1 (fr
Inventor
Donald H. Rubin
Edward L. Organ
Raymond N. Dubois
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vanderbilt University
Original Assignee
Vanderbilt University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanderbilt University filed Critical Vanderbilt University
Priority to CA2696653A priority Critical patent/CA2696653A1/fr
Publication of CA2305312A1 publication Critical patent/CA2305312A1/fr
Application granted granted Critical
Publication of CA2305312C publication Critical patent/CA2305312C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1051—Gene trapping, e.g. exon-, intron-, IRES-, signal sequence-trap cloning, trap vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1082—Preparation or screening gene libraries by chromosomal integration of polynucleotide sequences, HR-, site-specific-recombination, transposons, viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2720/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsRNA viruses
    • C12N2720/00011—Details
    • C12N2720/12011—Reoviridae
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/60—Vectors containing traps for, e.g. exons, promoters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Plant Pathology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne des procédés permettant d'identifier des gènes cellulaires nécessaires à la multiplication des virus et des gènes cellulaires nécessaires à la neutralisation tumorale. L'invention concerne donc des acides nucléiques et des procédés liés à la réduction ou à la prévention de l'infection virale ou du cancer. L'invention concerne également des procédés permettant de fournir des cultures cellulaires sensiblement dépourvues de virus et des procédés relatifs au criblage de gènes additionnels de ce type.
CA2305312A 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale Expired - Fee Related CA2305312C (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA2696653A CA2696653A1 (fr) 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6202197P 1997-10-10 1997-10-10
US60/062,021 1997-10-10
PCT/US1998/021276 WO1999019481A2 (fr) 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CA2696653A Division CA2696653A1 (fr) 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale

Publications (2)

Publication Number Publication Date
CA2305312A1 CA2305312A1 (fr) 1999-04-22
CA2305312C true CA2305312C (fr) 2010-03-23

Family

ID=22039706

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2305312A Expired - Fee Related CA2305312C (fr) 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale
CA2696653A Abandoned CA2696653A1 (fr) 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2696653A Abandoned CA2696653A1 (fr) 1997-10-10 1998-10-08 Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale

Country Status (5)

Country Link
EP (1) EP1021536A2 (fr)
JP (2) JP2001520012A (fr)
AU (1) AU9604198A (fr)
CA (2) CA2305312C (fr)
WO (1) WO1999019481A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001016323A2 (fr) * 1999-09-01 2001-03-08 Subsidiary N0.3, Inc. Compositions et procedes d'inhibition de l'infection due au virus de l'immunodeficience humaine a l'aide de genes cellulaires humains a regulation negative
JP2002300900A (ja) * 2001-04-05 2002-10-15 National Institute Of Advanced Industrial & Technology 腫瘍悪性化因子および腫瘍悪性化を抑制する化合物のスクリーニング方法
US20030087273A1 (en) * 2001-06-29 2003-05-08 Holzmayer Tanya A. Compositions and methods for inhibiting human immunodeficiency virus infection by down-regulating human cellular genes
US7691599B2 (en) 2002-05-02 2010-04-06 Zirus, Inc. Mammalian genes involved in viral infection and tumor suppression
EP2339009A1 (fr) * 2009-12-22 2011-06-29 Sandoz Ag Séquences promotrices inductibles à froid

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2046607C (fr) * 1989-02-14 2002-04-16 Rima Kaddurah-Daouk Inhibition de la transformation de cellules presentant un metabolisme des purines eleve
US5364783A (en) * 1990-05-14 1994-11-15 Massachusetts Institute Of Technology Retrovirus promoter-trap vectors
US5350835A (en) * 1991-11-05 1994-09-27 Board Of Regents, University Of Texas Cellular nucleic acid binding protein and uses thereof in regulating gene expression and in the treatment of aids
WO1997039119A1 (fr) * 1996-04-15 1997-10-23 Vanderbilt University Genes mammiferes impliques dans l'infection virale et la suppression de tumeurs

Also Published As

Publication number Publication date
JP2001520012A (ja) 2001-10-30
CA2305312A1 (fr) 1999-04-22
WO1999019481A2 (fr) 1999-04-22
AU9604198A (en) 1999-05-03
JP2009100780A (ja) 2009-05-14
CA2696653A1 (fr) 1999-04-22
WO1999019481A3 (fr) 1999-11-04
EP1021536A2 (fr) 2000-07-26

Similar Documents

Publication Publication Date Title
US7122373B1 (en) Human genes and gene expression products V
EP1440981A2 (fr) ADN complementaire humaine de pleine longueur
KR101126560B1 (ko) 약제 반응 예측 방법
Xiao et al. The lncRNA Malat1 is trafficked to the cytoplasm as a localized mRNA encoding a small peptide in neurons
Kirmizis et al. Genomic approaches that aid in the identification of transcription factor target genes
Humphrey et al. Cloning of cDNAs encoding human caldesmons
US20070020637A1 (en) Full-length cDNA
WO2002014500A2 (fr) Genes humains et produits d'expression genique
EP1263956A2 (fr) Nouveaux genes humains et leurs produits d'expression
JP2008301825A (ja) ウイルス感染および腫瘍抑制に関与する哺乳動物遺伝子
US6777177B1 (en) Mammalian genes involved in viral infection and tumor suppression
CA2696653A1 (fr) Genes mammaliens intervenant dans l'infection virale et la neutralisation tumorale
EP1163338A2 (fr) Genes mesenchymateux humains et produits d'expression
AU2006220384A1 (en) Mammalian Genes Involved in Viral Infection and Tumor Suppression
Liu et al. Identification and characterization of P15RS, a novel P15INK4b related gene on G1/S progression
JPH10502535A (ja) ｃ−ｆｏｓプロモーター活性化タンパク質をコードする核酸を同定する方法
JP2001507943A (ja) Ｕｃｐ２遺伝子発現の制御因子
US5851821A (en) DNA Replication-regulating genes
WO2001072781A9 (fr) Genes humains et produits d'expression genique xvi
Qi et al. Isolation of novel differentially expressed genes related to human glioma using cDNA microarray and characterizations of two novel full-length genes
EP4350005A1 (fr) Procédé de criblage d'arnm introduit de l'extérieur pouvant exister pendant une longue période de temps dans une cellule
Zhu A Functional Tandem Repeat VNTR2-1 in Human Telomerase Gene Regulation
WO1999057292A9 (fr) Sequences genomiques en amont de la region codante du gene ifn-alpha2 destinees a la production et a l'administration de proteines
AU780210B2 (en) Mammalian genes involved in viral infection and tumor suppression
JP2024520437A5 (fr)

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20131009