CA2305801A1 - Polymorphe d'ethyl 4-(8-chloro-5, 6,-dihydro-11h- benzo[5,6]cyclohepta [1,2-b]pyridine -11-ylidene)-1- piperidene carboxylate - Google Patents

Polymorphe d'ethyl 4-(8-chloro-5, 6,-dihydro-11h- benzo[5,6]cyclohepta [1,2-b]pyridine -11-ylidene)-1- piperidene carboxylate Download PDF

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Publication number
CA2305801A1
CA2305801A1 CA002305801A CA2305801A CA2305801A1 CA 2305801 A1 CA2305801 A1 CA 2305801A1 CA 002305801 A CA002305801 A CA 002305801A CA 2305801 A CA2305801 A CA 2305801A CA 2305801 A1 CA2305801 A1 CA 2305801A1
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CA
Canada
Prior art keywords
vwd
loratadine
polymorph form
polymorph
effective amount
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002305801A
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English (en)
Inventor
Dinesh Gala
Donald J. Dibenedetto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
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Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2305801A1 publication Critical patent/CA2305801A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

On décrit une forme 2 d'un polymorphe d'éthyle 4-(8-chloro-5, 6,-dihydro-11H- benzo[5,6]cyclohepta [1,2-b]pyridine-11-ylidène)-1- pipéridène carboxylate (ci-après dénommé "loratadine") de la formule (I). On décrit également des compositions pharmaceutiques contenant la forme 2 dudit polymorphe et des procédés d'utilisation de ladite forme 2 pour traiter des réactions allergiques chez des mammifères comme l'être humain.
CA002305801A 1997-10-10 1998-10-08 Polymorphe d'ethyl 4-(8-chloro-5, 6,-dihydro-11h- benzo[5,6]cyclohepta [1,2-b]pyridine -11-ylidene)-1- piperidene carboxylate Abandoned CA2305801A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94888697A 1997-10-10 1997-10-10
US08/948,886 1997-10-10
PCT/US1998/020919 WO1999019322A1 (fr) 1997-10-10 1998-10-08 POLYMORPHE D'ETHYL 4-(8-CHLORO-5, 6,-DIHYDRO-11H- BENZO[5,6]CYCLOHEPTA [1,2-b]PYRIDINE -11-YLIDENE)-1- PIPERIDENE CARBOXYLATE

Publications (1)

Publication Number Publication Date
CA2305801A1 true CA2305801A1 (fr) 1999-04-22

Family

ID=25488352

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002305801A Abandoned CA2305801A1 (fr) 1997-10-10 1998-10-08 Polymorphe d'ethyl 4-(8-chloro-5, 6,-dihydro-11h- benzo[5,6]cyclohepta [1,2-b]pyridine -11-ylidene)-1- piperidene carboxylate

Country Status (5)

Country Link
EP (1) EP1021436A1 (fr)
JP (1) JP2001519428A (fr)
AU (1) AU9683798A (fr)
CA (1) CA2305801A1 (fr)
WO (1) WO1999019322A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0313231A (pt) * 2002-08-05 2007-07-24 Sandoz Ag sal e polimorfos de hemifumarato de desloratadina

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4282233B1 (en) * 1980-06-19 2000-09-05 Schering Corp Antihistaminic 11-(4-piperidylidene)-5h-benzoÄ5,6Ü-cyclohepta-Ä1,2Ü-pyridines
US5089496A (en) * 1986-10-31 1992-02-18 Schering Corporation Benzo[5,6]cycloheptapyridine compounds, compositions and method of treating allergies
ZA914764B (en) * 1990-06-22 1992-03-25 Schering Corp Bis-benzo or benzopyrido cyclohepta piperidene,piperidylidene and piperazine compounds,compositions and methods of use
ES2042421B1 (es) * 1992-05-22 1994-08-01 Uriach & Cia Sa J Procedimiento para la obtencion de la 8-cloro-11-*1-*(5-metil-3-piridil)metil*-4-piperidiliden*-6,11-dihidro-5h-benzo*5,6*ciclohepta*1,2-b*piridina.
SG48750A1 (en) * 1993-10-15 1998-05-18 Schering Corp Tricyclic carbonate compounds useful for inhabition of g-protein function for treatment of proliferative diseases

Also Published As

Publication number Publication date
AU9683798A (en) 1999-05-03
JP2001519428A (ja) 2001-10-23
EP1021436A1 (fr) 2000-07-26
WO1999019322A1 (fr) 1999-04-22

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