CA2306565A1 - Carbapenem antibacterial compounds, compositions and methods of treatment - Google Patents

Carbapenem antibacterial compounds, compositions and methods of treatment Download PDF

Info

Publication number
CA2306565A1
CA2306565A1 CA002306565A CA2306565A CA2306565A1 CA 2306565 A1 CA2306565 A1 CA 2306565A1 CA 002306565 A CA002306565 A CA 002306565A CA 2306565 A CA2306565 A CA 2306565A CA 2306565 A1 CA2306565 A1 CA 2306565A1
Authority
CA
Canada
Prior art keywords
mmol
substituted
groups
ethyl
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002306565A
Other languages
English (en)
French (fr)
Inventor
Lovji D. Cama
Ronald W. Ratcliffe
Robert R. Wilkening
Kenneth J. Wildonger
Wanying Sun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9806431.4A external-priority patent/GB9806431D0/en
Application filed by Individual filed Critical Individual
Publication of CA2306565A1 publication Critical patent/CA2306565A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
    • C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
    • C07D477/14—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002306565A 1997-10-23 1998-10-19 Carbapenem antibacterial compounds, compositions and methods of treatment Abandoned CA2306565A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6303197P 1997-10-23 1997-10-23
US60/063,031 1997-10-23
GBGB9806431.4A GB9806431D0 (en) 1998-03-25 1998-03-25 Carbapenem antibacterial compounds,compositions containing such compounds and methods of treatment
GB9806431.4 1998-03-25
PCT/US1998/022110 WO1999020627A1 (en) 1997-10-23 1998-10-19 Carbapenem antibacterial compounds, compositions and methods of treatment

Publications (1)

Publication Number Publication Date
CA2306565A1 true CA2306565A1 (en) 1999-04-29

Family

ID=26313358

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002306565A Abandoned CA2306565A1 (en) 1997-10-23 1998-10-19 Carbapenem antibacterial compounds, compositions and methods of treatment

Country Status (5)

Country Link
EP (1) EP1027352A4 (de)
JP (1) JP2002509856A (de)
AU (1) AU739799B2 (de)
CA (1) CA2306565A1 (de)
WO (1) WO1999020627A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2449060A1 (en) * 2001-06-01 2002-12-12 Nikolai Ignatyev Process for the preparation of compounds containing perfluoroalkanesulfonic acid groups
US9771348B2 (en) 2013-07-25 2017-09-26 Dong-A St Co., Ltd Method for preparing benzamide derivative, novel intermediate used in preparation of benzamide, and method for preparing novel intermediate

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993016080A1 (fr) * 1992-02-06 1993-08-19 Yamanouchi Pharmaceutical Co., Ltd. Nouveau derive de carbapenem
US5451579A (en) * 1994-02-15 1995-09-19 Merck & Co., Inc. 1-β-methyl-carbapenem, compositions containing same and methods of use
NZ332183A (en) * 1996-04-24 2000-05-26 Merck & Co Inc Carbapenem antibacterial compounds substituted in the 2-position by a napthosultam, compositions and use for treating bacterial infections
US5756725A (en) * 1996-04-24 1998-05-26 Merck & Co., Inc. Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
JP2002515882A (ja) * 1996-09-13 2002-05-28 メルク エンド カンパニー インコーポレーテッド カルバペネム系抗菌化合物、該化合物を含む組成物および治療方法

Also Published As

Publication number Publication date
EP1027352A1 (de) 2000-08-16
AU1103099A (en) 1999-05-10
JP2002509856A (ja) 2002-04-02
EP1027352A4 (de) 2001-09-19
WO1999020627A1 (en) 1999-04-29
AU739799B2 (en) 2001-10-18

Similar Documents

Publication Publication Date Title
EP0906313B1 (de) Antibakterielle carbapenem-verbindungen, sie enthaltende zusammensetzungen undbehandlungsverfahren
US6399597B1 (en) 1,8-naphthosultamylmethyl carbapenem antibacterial compounds, compositions containing such compounds and methods treatment
WO1995025108A1 (en) Carbapenem compounds, compositions and methods of treatment
AU732335B2 (en) 3-(iodophenoxymethyl) carbapenem antibacterials
EP1028962B1 (de) Antibakterielle carbapenem-verbindungen, zusammensetzungen, die diese verbindungen enthalten und behandlungsmethoden
AU739799B2 (en) Carbapenem antibacterial compounds, compositions and methods of treatment
US6294529B1 (en) Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US6255300B1 (en) Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
CA2335510A1 (en) Naphtho[1,8-de]thiasin-2-yl methyl carbapenem antibacterials
AU735599B2 (en) Antibacterial carbapenems, compositions and methods of treatmemt
AU4184497A (en) Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
US5994343A (en) Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
EP0977567A1 (de) Antibakterielle carbapenem-verbindungen, die enthaltende zusammensetzungen und behandlungsmethoden
CA2298997A1 (en) Carbapenems with naphthosultam derivative linked via methylene
CA2306399A1 (en) Antibacterial carbapenems, compositions and methods of treatment
CA2335497A1 (en) Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment
CA2335538A1 (en) (heterocyclic)methyl substituted carbapenem antibacterials
EP1089999A1 (de) Antibakterielle, heterozyklomethyl-substituierte carbapenem-verbindungen
CA2335507A1 (en) Carbapenem antibacterial compounds, compositions containing such compounds and methods of treatment

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead