CA2306761A1 - Spectrometre de mobilite ionique a piegeage d'echantillons pour detecteur ambulatoire de molecules - Google Patents
Spectrometre de mobilite ionique a piegeage d'echantillons pour detecteur ambulatoire de molecules Download PDFInfo
- Publication number
- CA2306761A1 CA2306761A1 CA002306761A CA2306761A CA2306761A1 CA 2306761 A1 CA2306761 A1 CA 2306761A1 CA 002306761 A CA002306761 A CA 002306761A CA 2306761 A CA2306761 A CA 2306761A CA 2306761 A1 CA2306761 A1 CA 2306761A1
- Authority
- CA
- Canada
- Prior art keywords
- sample
- reaction region
- ims
- ion mobility
- vapor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 238000001514 detection method Methods 0.000 title claims description 17
- 238000006243 chemical reaction Methods 0.000 claims abstract description 52
- 238000009833 condensation Methods 0.000 claims abstract description 7
- 230000005494 condensation Effects 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 10
- 238000010438 heat treatment Methods 0.000 claims description 6
- 238000001816 cooling Methods 0.000 claims description 5
- 150000001875 compounds Chemical class 0.000 abstract description 12
- 238000000752 ionisation method Methods 0.000 abstract description 2
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 239000007789 gas Substances 0.000 description 29
- 150000002500 ions Chemical class 0.000 description 19
- 238000005070 sampling Methods 0.000 description 14
- 239000003814 drug Substances 0.000 description 7
- 229940079593 drug Drugs 0.000 description 7
- 238000002347 injection Methods 0.000 description 7
- 239000007924 injection Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 230000008901 benefit Effects 0.000 description 5
- 230000005684 electric field Effects 0.000 description 5
- 238000010586 diagram Methods 0.000 description 4
- 239000000470 constituent Substances 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 238000003795 desorption Methods 0.000 description 3
- 239000002360 explosive Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000012159 carrier gas Substances 0.000 description 2
- ZPUCINDJVBIVPJ-LJISPDSOSA-N cocaine Chemical compound O([C@H]1C[C@@H]2CC[C@@H](N2C)[C@H]1C(=O)OC)C(=O)C1=CC=CC=C1 ZPUCINDJVBIVPJ-LJISPDSOSA-N 0.000 description 2
- 238000004891 communication Methods 0.000 description 2
- 238000010828 elution Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000000376 reactant Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000012808 vapor phase Substances 0.000 description 2
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229960003920 cocaine Drugs 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960002069 diamorphine Drugs 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000004081 narcotic agent Substances 0.000 description 1
- 230000003533 narcotic effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
- G01N27/622—Ion mobility spectrometry
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Health & Medical Sciences (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
L'invention concerne un spectromètre de mobilité ionique (IMS) (100) "froid" qui fonctionne délibérément à une température suffisamment basse pour que des vapeurs échantillonnées se condensent, c'est-à-dire soient piégées, dans le dispositif IMS (100) après leur introduction avec une garniture de condensation (117) dans une région de réaction (102) du dispositif IMS (100). Le piégeage délibéré des vapeurs dans le dispositif IMS (100) enlève de manière active l'échantillon du procédé d'ionisation parce qu'après la condensation, la pression de la vapeur du composé à la température de fonctionnement du dispositif IMS (100) est négligeable. Etant donné que le composé n'est plus présent sous forme de vapeur, la production ionique n'est plus effectuée à une vitesse suffisante pour être détectée.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6268297P | 1997-10-22 | 1997-10-22 | |
| US60/062,682 | 1997-10-22 | ||
| PCT/US1998/022092 WO1999021212A1 (fr) | 1997-10-22 | 1998-10-20 | Spectrometre de mobilite ionique a piegeage d'echantillons pour detecteur ambulatoire de molecules |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2306761A1 true CA2306761A1 (fr) | 1999-04-29 |
Family
ID=22044122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002306761A Abandoned CA2306761A1 (fr) | 1997-10-22 | 1998-10-20 | Spectrometre de mobilite ionique a piegeage d'echantillons pour detecteur ambulatoire de molecules |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1025577A1 (fr) |
| JP (1) | JP2001521268A (fr) |
| CA (1) | CA2306761A1 (fr) |
| WO (1) | WO1999021212A1 (fr) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2320800A1 (fr) | 1998-02-11 | 1999-08-19 | Lawrence V. Haley | Systeme de detection portable avec gc/ims |
| US6815668B2 (en) | 1999-07-21 | 2004-11-09 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for chromatography-high field asymmetric waveform ion mobility spectrometry |
| US6690004B2 (en) | 1999-07-21 | 2004-02-10 | The Charles Stark Draper Laboratory, Inc. | Method and apparatus for electrospray-augmented high field asymmetric ion mobility spectrometry |
| US7098449B1 (en) | 1999-07-21 | 2006-08-29 | The Charles Stark Draper Laboratory, Inc. | Spectrometer chip assembly |
| US6806463B2 (en) | 1999-07-21 | 2004-10-19 | The Charles Stark Draper Laboratory, Inc. | Micromachined field asymmetric ion mobility filter and detection system |
| US6815669B1 (en) | 1999-07-21 | 2004-11-09 | The Charles Stark Draper Laboratory, Inc. | Longitudinal field driven ion mobility filter and detection system |
| WO2003005016A1 (fr) | 2001-06-30 | 2003-01-16 | Sionex Corporation | Systeme de collecte de donnees et d'identification d'especes d'ions dans un champ electrique |
| US7274015B2 (en) | 2001-08-08 | 2007-09-25 | Sionex Corporation | Capacitive discharge plasma ion source |
| US6630662B1 (en) * | 2002-04-24 | 2003-10-07 | Mds Inc. | Setup for mobility separation of ions implementing an ion guide with an axial field and counterflow of gas |
| JP4163556B2 (ja) * | 2003-05-30 | 2008-10-08 | 浜松ホトニクス株式会社 | イオン移動度検出器 |
| JP4200053B2 (ja) * | 2003-06-09 | 2008-12-24 | 浜松ホトニクス株式会社 | イオン移動度検出器 |
| WO2007014303A2 (fr) | 2005-07-26 | 2007-02-01 | Sionex Corporation | Analyseur ultra-compact par mobilite ionique, procede et systeme |
| GB0620748D0 (en) | 2006-10-19 | 2006-11-29 | Smiths Group Plc | Spectrometer apparatus |
| GB0625479D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detection apparatus |
| GB0625478D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detection apparatus |
| GB0625480D0 (en) | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detector apparatus, pre-concentrators and methods |
| GB0625481D0 (en) * | 2006-12-20 | 2007-01-31 | Smiths Group Plc | Detector apparatus and pre-concentrators |
| US8217344B2 (en) | 2007-02-01 | 2012-07-10 | Dh Technologies Development Pte. Ltd. | Differential mobility spectrometer pre-filter assembly for a mass spectrometer |
| US7895881B2 (en) * | 2007-10-18 | 2011-03-01 | Eads Deutschland Gmbh | Apparatus for detection of chemical or biological substances and method for cleaning the apparatus |
| GB2461346B (en) | 2008-07-04 | 2013-02-13 | Smiths Group Plc | Electrical connectors |
| GB201314252D0 (en) * | 2013-08-08 | 2013-09-25 | Smiths Detection Watford Ltd | Apparatus and method |
| WO2015097462A1 (fr) * | 2013-12-24 | 2015-07-02 | Micromass Uk Limited | Ims à onde progressive à contre-courant de gaz |
| GB201808936D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808890D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808892D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
| GB201808894D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Mass spectrometer |
| GB201808912D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| GB201808893D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| WO2019229463A1 (fr) | 2018-05-31 | 2019-12-05 | Micromass Uk Limited | Spectromètre de masse comportant une région de fragmentation |
| GB201808949D0 (en) * | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| WO2019229469A1 (fr) | 2018-05-31 | 2019-12-05 | Micromass Uk Limited | Spectromètre de masse |
| GB201808932D0 (en) | 2018-05-31 | 2018-07-18 | Micromass Ltd | Bench-top time of flight mass spectrometer |
| CN112858455A (zh) * | 2019-11-26 | 2021-05-28 | 中国科学院大连化学物理研究所 | 一种用于离子迁移谱的高通量颗粒物采集进样装置及方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5083019A (en) * | 1990-08-21 | 1992-01-21 | Environmental Technologies Group, Inc. | Preconcentrator for ion mobility spectrometer |
| US5189301A (en) * | 1991-08-20 | 1993-02-23 | Cpad Holdings, Ltd. | Simple compact ion mobility spectrometer having a focusing electrode which defines a non-uniform field for the drift region |
-
1998
- 1998-10-20 CA CA002306761A patent/CA2306761A1/fr not_active Abandoned
- 1998-10-20 WO PCT/US1998/022092 patent/WO1999021212A1/fr not_active Ceased
- 1998-10-20 JP JP2000517437A patent/JP2001521268A/ja active Pending
- 1998-10-20 EP EP98953728A patent/EP1025577A1/fr not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001521268A (ja) | 2001-11-06 |
| WO1999021212A1 (fr) | 1999-04-29 |
| EP1025577A1 (fr) | 2000-08-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued | ||
| FZDE | Discontinued |
Effective date: 20031020 |