CA2306991A1 - Site de liaison de ligand de rage et utilisations dudit site - Google Patents
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- CA2306991A1 CA2306991A1 CA002306991A CA2306991A CA2306991A1 CA 2306991 A1 CA2306991 A1 CA 2306991A1 CA 002306991 A CA002306991 A CA 002306991A CA 2306991 A CA2306991 A CA 2306991A CA 2306991 A1 CA2306991 A1 CA 2306991A1
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Landscapes
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Peptide isolé ayant une séquence d'acides aminés correspondant à la séquence d'acides aminés d'un domaine V d'un récepteur de produit terminal de glycation avancée (RAGE). La présente invention concerne également un peptide isolé ayant une séquence d'acides aminés A-Q-N-I-T-A-R-I-G-E-P-L-V-L-K-C-K-G-A-P-K-K-P-P-Q-R-L-E-W-K (Séq. ID No 1). Elle concerne encore une composition pharmaceutique comportant une quantité thérapeutiquement efficace d'un peptide isolé ayant une séquence d'acides aminés correspondant à la séquence d'acides aminés du domaine V de RAGE. Elle concerne enfin un procédé permettant d'inhiber l'interaction d'un peptide amyloïde .beta. avec un récepteur de produit terminal de glycation avancée qui est sur la surface d'une cellule. Ledit procédé consiste à mettre en contact la cellule avec le peptide ou un agent fonctionnellement équivalent, ledit peptide ou agent étant capable d'inhiber l'interaction du peptide amyloïde .beta. avec le récepteur de produit terminal de glycation avancée, et étant présent en quantité efficace pour provoquer ladite inhibition.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/948,131 | 1997-10-09 | ||
| US94813198A | 1998-10-09 | 1998-10-09 | |
| PCT/US1998/021346 WO1999018987A1 (fr) | 1997-10-09 | 1998-10-09 | Site de liaison de ligand de rage et utilisations dudit site |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2306991A1 true CA2306991A1 (fr) | 1999-04-22 |
Family
ID=25487338
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002306991A Abandoned CA2306991A1 (fr) | 1998-10-09 | 1998-10-09 | Site de liaison de ligand de rage et utilisations dudit site |
Country Status (1)
| Country | Link |
|---|---|
| CA (1) | CA2306991A1 (fr) |
-
1998
- 1998-10-09 CA CA002306991A patent/CA2306991A1/fr not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130607 |