CA2307221A1 - E-caprolactames .alpha.-amino polycycliques et composes connexes - Google Patents

E-caprolactames .alpha.-amino polycycliques et composes connexes Download PDF

Info

Publication number
CA2307221A1
CA2307221A1 CA002307221A CA2307221A CA2307221A1 CA 2307221 A1 CA2307221 A1 CA 2307221A1 CA 002307221 A CA002307221 A CA 002307221A CA 2307221 A CA2307221 A CA 2307221A CA 2307221 A1 CA2307221 A1 CA 2307221A1
Authority
CA
Canada
Prior art keywords
substituted
amino
dihydro
azepin
dibenz
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002307221A
Other languages
English (en)
Inventor
James E. Audia
Thomas E. Mabry
Jeffrey S. Nissen
Stacey L. Mcdaniel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Elan Pharmaceuticals LLC
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/996,422 external-priority patent/US6635632B1/en
Application filed by Individual filed Critical Individual
Publication of CA2307221A1 publication Critical patent/CA2307221A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrrole Compounds (AREA)

Abstract

L'invention concerne des ?-caprolactames .alpha.-amino polycycliques et des composés connexes, utiles comme intermédiaires synthétiques dans l'élaboration d'inhibiteurs de la libération et/ou de la synthèse des peptides .beta.-amyloïdes.
CA002307221A 1997-12-22 1998-10-29 E-caprolactames .alpha.-amino polycycliques et composes connexes Abandoned CA2307221A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US08/996,422 1997-12-22
US08/996,422 US6635632B1 (en) 1996-12-23 1997-12-22 Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
US10272698A 1998-06-22 1998-06-22
US09/102,726 1998-06-22
PCT/US1998/022637 WO1999032453A1 (fr) 1997-12-22 1998-10-29 ⊂-CAPROLACTAMES α-AMINO POLYCYCLIQUES ET COMPOSES CONNEXES

Publications (1)

Publication Number Publication Date
CA2307221A1 true CA2307221A1 (fr) 1999-07-01

Family

ID=26799672

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002307221A Abandoned CA2307221A1 (fr) 1997-12-22 1998-10-29 E-caprolactames .alpha.-amino polycycliques et composes connexes

Country Status (9)

Country Link
EP (1) EP1042298A1 (fr)
JP (1) JP2003521438A (fr)
KR (1) KR20010033408A (fr)
AU (1) AU1277799A (fr)
BR (1) BR9812773A (fr)
CA (1) CA2307221A1 (fr)
HU (1) HUP0100294A3 (fr)
IL (1) IL135564A0 (fr)
WO (1) WO1999032453A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ509241A (en) 1998-08-07 2003-08-29 Du Pont Pharm Co Succinoylamino lactams as inhibitors of alpha-beta protein production
JP4615727B2 (ja) 1998-12-24 2011-01-19 ブリストル−マイヤーズ スクイブ ファーマ カンパニー Ａβタンパク質生成の阻害剤としてのスクシノイルアミノベンゾジアゼピン
JP2003503476A (ja) * 1999-07-06 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド 環化アミド誘導体
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
CA2377221A1 (fr) * 1999-09-13 2001-03-22 Bristol-Myers Squibb Pharma Company Hydroxyalkanoyl aminolactames et structures associees, inhibiteurs de la production de la proteine a.beta.
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
EP1222176A1 (fr) * 1999-10-08 2002-07-17 Bristol-Myers Squibb Pharma Company AMINO SULFONAMIDES DE LACTAME UTILISES COMME INHIBITEURS DE LA PRODUCTION DE PROTEINE A$g(b)
US6525044B2 (en) 2000-02-17 2003-02-25 Bristol-Myers Squibb Company Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production
MXPA02009729A (es) 2000-04-03 2003-03-27 Bristol Myers Squibb Pharma Co Lactamas ciclicas como inhibidores de la produccion de la proteina a-beta.
AU2001253090A1 (en) 2000-04-03 2001-10-15 Bristol-Myers Squibb Pharma Company Cyclic lactams as inhibitors of abeta protein production
US6632812B2 (en) * 2000-04-11 2003-10-14 Dupont Pharmaceuticals Company Substituted lactams as inhibitors of Aβ protein production
CA2379445C (fr) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactames substitues par des succinates cycliques en tant qu'inhibiteurs de la production de la proteine .beta.
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4666829A (en) * 1985-05-15 1987-05-19 University Of California Polypeptide marker for Alzheimer's disease and its use for diagnosis
DK1298436T3 (da) * 1992-10-26 2010-10-25 Elan Pharm Inc Fremgangsmåde til identificering af inhibitorforbindelser for frisætning af beta-amyloidpeptid (BAP)
CZ184194A3 (en) * 1993-08-09 1995-03-15 Lilly Co Eli Aspartylprotease inhibitor and method of identifying thereof
US5580979A (en) * 1994-03-15 1996-12-03 Trustees Of Tufts University Phosphotyrosine peptidomimetics for inhibiting SH2 domain interactions
US6251928B1 (en) * 1994-03-16 2001-06-26 Eli Lilly And Company Treatment of alzheimer's disease employing inhibitors of cathepsin D
HRP970705A2 (en) * 1996-12-23 1998-10-31 Warren J. Porter CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING "beta" -AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
HRP980093A2 (en) * 1997-02-28 1998-12-31 Lilly Co Eli Heterocyclic compounds, pharmaceutical compositions comprising same, and methods for inhibiting "beta"-amyloid peptide release and/or its synthesis by use of such compounds

Also Published As

Publication number Publication date
EP1042298A1 (fr) 2000-10-11
WO1999032453A1 (fr) 1999-07-01
HUP0100294A3 (en) 2003-04-28
HUP0100294A2 (hu) 2001-09-28
IL135564A0 (en) 2001-05-20
BR9812773A (pt) 2000-10-10
KR20010033408A (ko) 2001-04-25
AU1277799A (en) 1999-07-12
JP2003521438A (ja) 2003-07-15

Similar Documents

Publication Publication Date Title
JP2002518481A (ja) β−アミロイドペプチドの放出および／またはその合成を阻害するための化合物
US6509331B1 (en) Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JP2002518451A (ja) 環状アミノ酸化合物およびその医薬組成物、並びにそれら化合物を用いたβ−アミロイドペプチドの放出および／またはその合成を阻害する方法
EP2872490B1 (fr) Benzo[b]azépin-2-ones antiprolifératives
CA2307221A1 (fr) E-caprolactames .alpha.-amino polycycliques et composes connexes
CA2325388A1 (fr) Composes permettant d'inhiber la liberation et/ou la synthese de peptide beta-amyloide
US20080132704A1 (en) 3-Substituted quinuclidines and their use
EP1599476B1 (fr) Derives aryle diazabicycliques
CA2425497C (fr) Dihydrate de n-(((s)-2-hydroxy-3-methyl-butyryl(l-alanin-1- yl)-(s)-1-amino-3-methyl-2,3,4,5-tetrahydro-1h-3-benzazepin-2-one et son utilisation pour le traitement de la maladie d'alzheimer
AU2002224321A1 (en) Lactam compound
HUP0200133A2 (en) Piperidine and piperazine derivatives as inhibitors of the abetha fibril formation, process for their preparation and pharmaceutical compositions containing them
CA2390376A1 (fr) Composes contenant des .beta.-acides amines utiles pour inhiber la liberation et/ou la synthese du peptide .beta.-amyloide
CN101970438A (zh) 新的1，4-二氮杂-二环[3.2.2]壬基嘧啶衍生物及它们的医药应用
CA2425558C (fr) Compose lactame
US6958330B1 (en) Polycyclic α-amino-ε-caprolactams and related compounds
CA2388750A1 (fr) Composes contenant des .beta.-acides amines utiles pour inhiber la liberation et/ou la synthese du peptide .beta.-amyloide
TWI311557B (en) Pharmaceutically active diazepanes
US6528505B1 (en) Cyclic amino acid compounds pharmaceutical compositions comprising same and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
MXPA00005540A (en) POLYCYCLIC&agr;-AMINO-?-CAPROLACTAMS AND RELATED COMPOUNDS
US6774125B2 (en) Deoxyamino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
JPH08225571A (ja) ６−アルコキシ−１ｈ−ベンゾトリアゾール−５−カルボキサミド誘導体及びその中間体並びに該化合物を含有する医薬組成物

Legal Events

Date Code Title Description
FZDE Discontinued