CA2307716A1 - Reactifs et procedes utiles pour detecter des maladies du sein - Google Patents

Reactifs et procedes utiles pour detecter des maladies du sein Download PDF

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Publication number
CA2307716A1
CA2307716A1 CA002307716A CA2307716A CA2307716A1 CA 2307716 A1 CA2307716 A1 CA 2307716A1 CA 002307716 A CA002307716 A CA 002307716A CA 2307716 A CA2307716 A CA 2307716A CA 2307716 A1 CA2307716 A1 CA 2307716A1
Authority
CA
Canada
Prior art keywords
sequence
polynucleotide
specific
group
polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002307716A
Other languages
English (en)
Inventor
Patricia A. Billing-Medel
Maurice Cohen
Tracey L. Colpitts
Paula N. Friedman
Julian Gordon
Edward N. Granados
Steven C. Hodges
Michael R. Klass
Jon D. Kratochvil
John C. Russell
Stephen D. Stroupe
Hong Yu
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of CA2307716A1 publication Critical patent/CA2307716A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention concerne un ensemble séquences d'ADNc, contiguës et se chevauchant partiellement, ainsi que des polypeptides codés par ces séquences, dénommés BS247 et transcrits à partir d'un tissu mammaire. Ces séquences sont utiles pour détecter, diagnostiquer, déterminer les stades d'une maladie évolutive, surveiller, pronostiquer, obtenir une image in vivo, prévenir ou traiter, ou déterminer la prédisposition d'un individu à des maladies et pathologies du sein, comme le cancer du sein. L'invention concerne également des anticorps, lesquels se fixent de manière spécifique sur la protéine ou le polypeptide BS247 codé, ainsi que des agonistes ou inhibiteurs empêchant l'action du polypeptide BS247 spécifique du tissu mammaire, ces molécules étant utiles dans le traitement thérapeutique des maladies, tumeurs ou métastases du sein.
CA002307716A 1997-10-28 1998-10-28 Reactifs et procedes utiles pour detecter des maladies du sein Abandoned CA2307716A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US96883897A 1997-10-28 1997-10-28
US6343197P 1997-10-28 1997-10-28
US60/063,431 1997-10-28
US08/968,838 1997-10-28
PCT/US1998/022906 WO1999022027A1 (fr) 1997-10-28 1998-10-28 Reactifs et procedes utiles pour detecter des maladies du sein

Publications (1)

Publication Number Publication Date
CA2307716A1 true CA2307716A1 (fr) 1999-05-06

Family

ID=26743420

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002307716A Abandoned CA2307716A1 (fr) 1997-10-28 1998-10-28 Reactifs et procedes utiles pour detecter des maladies du sein

Country Status (3)

Country Link
EP (1) EP1027457A1 (fr)
CA (1) CA2307716A1 (fr)
WO (1) WO1999022027A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3354199A (en) * 1998-03-12 1999-09-27 Millennium Biotherapeutics, Inc. Prostate derived serine protease (pdsp) protein and nucleic acid molecules and uses therefor
AU2002230736A1 (en) * 2000-10-30 2002-05-15 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins
AU2002219988A1 (en) 2000-11-20 2002-05-27 Diadexus, Inc. Compositions and methods relating to breast specific genes and proteins

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6103237A (en) * 1993-07-22 2000-08-15 Hybritech Incorporated Stable variant hK2 polypeptide
US5962300A (en) * 1997-03-26 1999-10-05 Incyte Pharmaceuticals, Inc. Human kallikrein

Also Published As

Publication number Publication date
EP1027457A1 (fr) 2000-08-16
WO1999022027A1 (fr) 1999-05-06

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Legal Events

Date Code Title Description
FZDE Discontinued