CA2307979A1 - Novel production intermediate and process for producing pyridine derivative - Google Patents

Novel production intermediate and process for producing pyridine derivative Download PDF

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Publication number
CA2307979A1
CA2307979A1 CA002307979A CA2307979A CA2307979A1 CA 2307979 A1 CA2307979 A1 CA 2307979A1 CA 002307979 A CA002307979 A CA 002307979A CA 2307979 A CA2307979 A CA 2307979A CA 2307979 A1 CA2307979 A1 CA 2307979A1
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CA
Canada
Prior art keywords
formula
producing
represented
pyridine derivative
tautomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002307979A
Other languages
French (fr)
Other versions
CA2307979C (en
Inventor
Syotaro Watanabe
William R. Kem
Hun Ju Lee
Makoto Kajitani
Kazuo Maruhashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
University of Florida
Original Assignee
Individual
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Filing date
Publication date
Priority claimed from JP25272694A external-priority patent/JP3219946B2/en
Application filed by Individual filed Critical Individual
Publication of CA2307979A1 publication Critical patent/CA2307979A1/en
Application granted granted Critical
Publication of CA2307979C publication Critical patent/CA2307979C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

This invention relates to: (1) a compound represented by the formula (V), its tautomer and a mixture of the same;
(2) a process for producing the compound represented by the above-mentioned formula (V), its tautomer or a mixture of the same, which comprises reacting N-vinylpiperidone represented by the formula (I) with a nicotinate represented by the formula (II), wherein R represents a lower alkyl group, in the presence of a sodium alkoxide; (3) a process for producing a pyridine derivative represented by the formula (III), which comprises producing the compound represented by the formula (V), its tautomer or a mixture of the same by the process as described in the above (2), and then treating the obtained compound with an acid; and (4) a process for producing a pyridine derivative represented by the formula (IV), in which the treatment with an acid as described in the above (3) is followed by another treatment with a base.
Thus, the present invention provides industrial processes for producing pyridine derivatives represented by the formulae (III) and (IV) safely, economically, easily and efficiently without using any hazardous reagents.

(See formulae I, II, III) (See formulae IV , V)
CA002307979A 1994-09-22 1995-09-21 Novel production intermediate and process for producing pyridine derivative Expired - Fee Related CA2307979C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP25272694A JP3219946B2 (en) 1994-09-22 1994-09-22 New production intermediate and method for producing pyridine derivative
JPHEI6-252726 1994-09-22
CA002200604A CA2200604C (en) 1994-09-22 1995-09-21 Novel production intermediate and process for producing pyridine derivative

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA002200604A Division CA2200604C (en) 1994-09-22 1995-09-21 Novel production intermediate and process for producing pyridine derivative

Publications (2)

Publication Number Publication Date
CA2307979A1 true CA2307979A1 (en) 1996-03-28
CA2307979C CA2307979C (en) 2004-03-23

Family

ID=25679151

Family Applications (2)

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CA002307976A Expired - Fee Related CA2307976C (en) 1994-09-22 1995-09-21 Novel production intermediate and process for producing pyridine derivative
CA002307979A Expired - Fee Related CA2307979C (en) 1994-09-22 1995-09-21 Novel production intermediate and process for producing pyridine derivative

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA002307976A Expired - Fee Related CA2307976C (en) 1994-09-22 1995-09-21 Novel production intermediate and process for producing pyridine derivative

Country Status (1)

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CA (2) CA2307976C (en)

Also Published As

Publication number Publication date
CA2307979C (en) 2004-03-23
CA2307976C (en) 2004-03-23
CA2307976A1 (en) 1996-03-28

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