CA2308111C - Procede de melange ameliore dans des bouteilles pour agitateur rotatif - Google Patents

Procede de melange ameliore dans des bouteilles pour agitateur rotatif Download PDF

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Publication number
CA2308111C
CA2308111C CA2308111A CA2308111A CA2308111C CA 2308111 C CA2308111 C CA 2308111C CA 2308111 A CA2308111 A CA 2308111A CA 2308111 A CA2308111 A CA 2308111A CA 2308111 C CA2308111 C CA 2308111C
Authority
CA
Canada
Prior art keywords
rotation
bottle
roller bottle
rocking
mixing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2308111A
Other languages
English (en)
Other versions
CA2308111A1 (fr
Inventor
Joye L. Bramble
James A. Searles
Fernando J. Muzzio
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rutgers State University of New Jersey
Merck Sharp and Dohme LLC
Original Assignee
Rutgers State University of New Jersey
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9727128.2A external-priority patent/GB9727128D0/en
Application filed by Rutgers State University of New Jersey, Merck Sharp and Dohme LLC filed Critical Rutgers State University of New Jersey
Publication of CA2308111A1 publication Critical patent/CA2308111A1/fr
Application granted granted Critical
Publication of CA2308111C publication Critical patent/CA2308111C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/10—Rotating vessel
    • C12M27/12—Roller bottles; Roller tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M27/00—Means for mixing, agitating or circulating fluids in the vessel
    • C12M27/16—Vibrating; Shaking; Tilting

Landscapes

  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne un procédé permettant d'améliorer le mélange de substances dans une bouteille pour agitateur rotatif, ce procédé consistant à introduire de manière régulée des perturbations selon des écoulements axial et transversal. L'efficacité de ce procédé se traduit par un rendement amélioré des mises en culture cellulaire et une meilleure propagation virale dans les bouteilles pour agitateur rotatif, grâce à l'introduction des perturbations susmentionnées au cours du processus.
CA2308111A 1997-10-31 1998-10-27 Procede de melange ameliore dans des bouteilles pour agitateur rotatif Expired - Fee Related CA2308111C (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6385497P 1997-10-31 1997-10-31
US60/063,854 1997-10-31
US6737197P 1997-12-03 1997-12-03
US60/067,371 1997-12-03
GB9727128.2 1997-12-22
GBGB9727128.2A GB9727128D0 (en) 1997-12-22 1997-12-22 A method of improved mixing in roller bottles
PCT/US1998/022729 WO1999023204A1 (fr) 1997-10-31 1998-10-27 Procede de melange ameliore dans des bouteilles pour agitateur rotatif

Publications (2)

Publication Number Publication Date
CA2308111A1 CA2308111A1 (fr) 1999-05-14
CA2308111C true CA2308111C (fr) 2010-12-21

Family

ID=27269148

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2308111A Expired - Fee Related CA2308111C (fr) 1997-10-31 1998-10-27 Procede de melange ameliore dans des bouteilles pour agitateur rotatif

Country Status (5)

Country Link
EP (1) EP1027425A4 (fr)
JP (1) JP2001521736A (fr)
AU (1) AU737705B2 (fr)
CA (1) CA2308111C (fr)
WO (1) WO1999023204A1 (fr)

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3091435A (en) * 1961-01-30 1963-05-28 Curtiss Wright Corp Rotary-oscillatory device for mixing, tumbling, comminuting, and the like
DE1940865B2 (de) * 1968-08-10 1975-04-17 Monrick Holdings Ltd., Downsview, Ontario (Kanada) Einrichtung zum Behandeln von photographischem Material mit einer Behandlungsflüssigkeit
DE1957069B2 (de) * 1969-11-13 1973-07-26 Merz, Werner, 7911 Oberelchingen Entwicklungsgeraet fuer blattfoermige photographische filmmaterialien
US3982259A (en) * 1974-12-13 1976-09-21 Edward Van Baerle Photographic material processing module
US3981488A (en) * 1975-01-02 1976-09-21 Monrick Holdings Limited Carrier for processing photographic material and apparatus for rotating the carrier
DE2934328C2 (de) * 1979-08-24 1982-04-29 Stephan Dipl.-Chem. Dr.rer.nat. 8000 München Nees Verfahren zur Kultivierung matrixgebundener biologischer Zellsysteme sowie Vorrichtung zur Ausübung des Verfahrens
US4307965A (en) * 1980-05-30 1981-12-29 Innovative Medical Systems Corp. Mixing apparatus
JPS61138522A (ja) * 1984-12-11 1986-06-26 Matsushita Electric Ind Co Ltd 混合機
JPS62198334A (ja) * 1986-02-26 1987-09-02 カネボウ株式会社 植物の組織培養法
US5026650A (en) * 1988-06-30 1991-06-25 The United States Of Amercia As Represented By The Administrator Of The National Aeronautics And Space Administration Horizontally rotated cell culture system with a coaxial tubular oxygenator
GB9112836D0 (en) * 1991-06-14 1991-07-31 Medical Res Council Production of monoclonal antibodies
DE4229334C2 (de) * 1992-09-02 1995-12-21 Heraeus Instr Gmbh Rollflaschenähnliches Kulturgefäß für Zellkulturen
US5744102A (en) * 1996-01-30 1998-04-28 Chugai Biopharmaceuticals, Inc. Solid phase synthesizer
DE19612967A1 (de) * 1996-04-01 1997-10-02 Behringwerke Ag Verfahren zur Vermehrung von Influenzaviren in Zellkultur, sowie die durch das Verfahren erhältlichen Influenzaviren

Also Published As

Publication number Publication date
WO1999023204A1 (fr) 1999-05-14
EP1027425A1 (fr) 2000-08-16
EP1027425A4 (fr) 2006-04-19
AU737705B2 (en) 2001-08-30
CA2308111A1 (fr) 1999-05-14
JP2001521736A (ja) 2001-11-13
AU1201599A (en) 1999-05-24

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Effective date: 20131029