CA2308112A1 - Polypeptides de caspase-14 - Google Patents

Polypeptides de caspase-14 Download PDF

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Publication number
CA2308112A1
CA2308112A1 CA002308112A CA2308112A CA2308112A1 CA 2308112 A1 CA2308112 A1 CA 2308112A1 CA 002308112 A CA002308112 A CA 002308112A CA 2308112 A CA2308112 A CA 2308112A CA 2308112 A1 CA2308112 A1 CA 2308112A1
Authority
CA
Canada
Prior art keywords
caspase
polypeptide
amino acid
acid sequence
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002308112A
Other languages
English (en)
Inventor
Steven M. Ruben
Jian Ni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Human Genome Sciences Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2308112A1 publication Critical patent/CA2308112A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Cardiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne une nouvelle protéine Caspase-14 (également appelée ERICE) laquelle est un nouvel effecteur de l'apoptose. L'invention concerne notamment des molécules d'acide nucléique isolées codant la protéine Caspase-14 humaine. De plus, l'invention concerne des polypeptides de Caspase-14 de même que des vecteurs, des cellules hôtes et des méthodes de recombinaison permettant leur production. En outre, l'invention concerne des méthodes de criblage pour identifier des agonistes et des antagonistes de l'activité Caspase-14, de même que des méthodes thérapeutiques de traitement de maladies et de troubles associés à l'apoptose.
CA002308112A 1997-10-30 1998-09-30 Polypeptides de caspase-14 Abandoned CA2308112A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US6359297P 1997-10-30 1997-10-30
US60/063,592 1997-10-30
US7605098P 1998-02-26 1998-02-26
US60/076,050 1998-02-26
PCT/US1998/020452 WO1999023106A1 (fr) 1997-10-30 1998-09-30 Polypeptides de caspase-14

Publications (1)

Publication Number Publication Date
CA2308112A1 true CA2308112A1 (fr) 1999-05-14

Family

ID=26743557

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002308112A Abandoned CA2308112A1 (fr) 1997-10-30 1998-09-30 Polypeptides de caspase-14

Country Status (5)

Country Link
EP (1) EP1036086A1 (fr)
JP (1) JP2001521730A (fr)
AU (1) AU750170B2 (fr)
CA (1) CA2308112A1 (fr)
WO (1) WO1999023106A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6184244B1 (en) 1996-12-16 2001-02-06 Idun Pharmaceuticals, Inc. C-terminal modified (N-substituted)-2-indolyl dipeptides as inhibitors of the ICE/ced-3 family of cysteine proteases
US6340740B1 (en) 1997-08-26 2002-01-22 Thomas Jefferson University Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use
US6432628B1 (en) 1997-08-26 2002-08-13 Thomas Jefferson University Caspase-14, an apoptotic protease, nucleic acids encoding and methods of use
AU1521501A (en) * 1999-11-10 2001-06-06 Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw Use of caspase-14 and caspase-14 modulators to diagnose and/or treat skin, eye and brain disorders
AU2001271427A1 (en) * 2000-06-26 2002-01-08 Sugen, Inc. Novel proteases
CA2416691A1 (fr) * 2000-07-21 2002-01-31 Incyte Genomics, Inc. Proteases
WO2008025830A2 (fr) * 2006-09-01 2008-03-06 Vib Vzw Compositions d'écran solaire
JP5562015B2 (ja) * 2009-12-04 2014-07-30 株式会社 資生堂 皮膚バリアー機能回復促進物質のスクリーニング方法

Also Published As

Publication number Publication date
AU750170B2 (en) 2002-07-11
AU9673898A (en) 1999-05-24
JP2001521730A (ja) 2001-11-13
EP1036086A1 (fr) 2000-09-20
WO1999023106A1 (fr) 1999-05-14

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Legal Events

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