CA2308565A1 - Sequences pour cibler les cellules metastatiques - Google Patents
Sequences pour cibler les cellules metastatiques Download PDFInfo
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- CA2308565A1 CA2308565A1 CA002308565A CA2308565A CA2308565A1 CA 2308565 A1 CA2308565 A1 CA 2308565A1 CA 002308565 A CA002308565 A CA 002308565A CA 2308565 A CA2308565 A CA 2308565A CA 2308565 A1 CA2308565 A1 CA 2308565A1
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- caveolin
- cells
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- gene
- cell
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/318—Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
- C12N2310/3181—Peptide nucleic acid, PNA
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
La présente invention à trait à des procédés permettant de diagnostiquer, d'évaluer ou de traiter les maladies métastatiques en utilisant des séquences métastatiques, telles que des séquences de cavéoline, pour cibler des cellules métastatiques. Selon les procédés de cette invention, certains cancers, notamment le cancer métastatique de la prostate, peuvent être traités par des thérapies qui suppriment l'expression du gène de la cavéoline. Par ailleurs, cette invention concerne des technologies biologiques conçues pour bloquer l'activité de la cavéoline ou la fonction de la cavéole, notamment la distribution par vecteurs des séquences de cavéoline anti-sens, l'utilisation d'anticorps anti-cavéoline, l'utilisation de promoteurs, ainsi que d'autres approches ciblant l'expression de la cavéole.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6435197P | 1997-11-05 | 1997-11-05 | |
| US60/064,351 | 1997-11-05 | ||
| PCT/US1998/023542 WO1999022773A2 (fr) | 1997-11-05 | 1998-11-05 | Sequences pour cibler les cellules metastatiques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2308565A1 true CA2308565A1 (fr) | 1999-05-14 |
Family
ID=22055348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002308565A Abandoned CA2308565A1 (fr) | 1997-11-05 | 1998-11-05 | Sequences pour cibler les cellules metastatiques |
Country Status (5)
| Country | Link |
|---|---|
| US (4) | US6252058B1 (fr) |
| EP (1) | EP1029048A2 (fr) |
| AU (1) | AU734476B2 (fr) |
| CA (1) | CA2308565A1 (fr) |
| WO (1) | WO1999022773A2 (fr) |
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| USRE38490E1 (en) | 1995-11-16 | 2004-04-06 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| USRE38392E1 (en) | 1996-01-30 | 2004-01-20 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| CA2308565A1 (fr) | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences pour cibler les cellules metastatiques |
| EP1062340A2 (fr) * | 1998-03-13 | 2000-12-27 | The Baylor College of Medicine | Compositions et methodes de traitement et de prevention de troubles metastatiques |
| EP1076091A1 (fr) * | 1999-08-09 | 2001-02-14 | Universite Catholique De Louvain | Composé ou composition pharmaceutique pour la prévention et/ou le traitement d'ischémie cardiaque, de maladies vasculaires périphériques, de tumeurs et de plaies |
| AUPQ808700A0 (en) * | 2000-06-09 | 2000-07-06 | Honeywell Limited | Human-machine interface |
| US20030114410A1 (en) * | 2000-08-08 | 2003-06-19 | Technion Research And Development Foundation Ltd. | Pharmaceutical compositions and methods useful for modulating angiogenesis and inhibiting metastasis and tumor fibrosis |
| KR100489188B1 (ko) * | 2000-09-08 | 2005-05-17 | 재단법인서울대학교산학협력재단 | 카베올린을 이용한 노화 세포의 검출방법, 세포의 노화유도용 조성물 및 노화 유도 방법 |
| MXPA03004579A (es) * | 2000-11-28 | 2003-09-04 | Wyeth Corp | Analisis de expresion de acidos nucleicos del regulador de cromatina dependiente de actina y polipeptidos utiles en diagnostico y tratamiento del cancer de prostata. |
| US7037652B2 (en) * | 2000-11-28 | 2006-05-02 | Wyeth | Expression analysis of KIAA nucleic acids and polypeptides useful in the diagnosis and treatment of prostate cancer |
| EP2316976A1 (fr) * | 2000-11-28 | 2011-05-04 | Wyeth LLC | Analyse de l'expression des acides nucléiques FKBP et polypeptides utiles dans le diagnostic et le traitement du cancer de la prostate |
| ES2330201T3 (es) * | 2001-01-26 | 2009-12-07 | Selexis S.A. | Regiones de union a la matriz y metodos para el uso de las mismas. |
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| US7462491B2 (en) | 2002-01-31 | 2008-12-09 | Baylor College Of Medicine | Methods and compositions for diagnosis and monitoring of prostate cancer progression by detection of serum caveolin |
| KR100614523B1 (ko) * | 2003-07-24 | 2006-08-22 | 재단법인서울대학교산학협력재단 | 노화세포의 생물학적 기능 회복 방법 |
| EP1959011B1 (fr) | 2003-10-24 | 2012-03-28 | Selexis S.A. | Transfert et expression génique à efficacité élevée dans des cellules de mammifères au moyen d'une procédure de transfection multiple de séquences MAR |
| US20050202407A1 (en) * | 2003-12-01 | 2005-09-15 | Baylor College Of Medicine | Methods and assays for screening anti-neoplastic therapeutic agents |
| AU2004308260A1 (en) * | 2003-12-12 | 2005-07-14 | University Of Rochester | Non-androgen dependent roles for androgen receptor and non-androgen related inhibitors of androgen receptor |
| US7951780B2 (en) * | 2004-02-25 | 2011-05-31 | Astellas Pharma Inc. | Antitumor agent |
| US7449196B2 (en) * | 2004-07-09 | 2008-11-11 | Robert Sabin | Anti tumor compositions and methods of use |
| US9492400B2 (en) | 2004-11-04 | 2016-11-15 | Massachusetts Institute Of Technology | Coated controlled release polymer particles as efficient oral delivery vehicles for biopharmaceuticals |
| US20070021365A1 (en) * | 2005-06-21 | 2007-01-25 | The Board Of Trustees Of The Leland Stanford Junior University | Inhibition of Lysyl oxidase for treating tumor growth and diagnostics relating thereto |
| US20070225242A1 (en) * | 2005-06-21 | 2007-09-27 | The Board Of Trustees Of The Leland Stanford Junior University | Method and composition for treating and preventing tumor metastasis in vivo |
| US9267937B2 (en) | 2005-12-15 | 2016-02-23 | Massachusetts Institute Of Technology | System for screening particles |
| EP2007435B1 (fr) | 2006-03-31 | 2019-12-18 | Massachusetts Institute Of Technology | Système pour l'administration ciblée d'agents thérapeutiques |
| CA2652280C (fr) | 2006-05-15 | 2014-01-28 | Massachusetts Institute Of Technology | Polymeres pour particules fonctionnelles |
| US20110052697A1 (en) * | 2006-05-17 | 2011-03-03 | Gwangju Institute Of Science & Technology | Aptamer-Directed Drug Delivery |
| US9381477B2 (en) | 2006-06-23 | 2016-07-05 | Massachusetts Institute Of Technology | Microfluidic synthesis of organic nanoparticles |
| WO2008019142A2 (fr) * | 2006-08-04 | 2008-02-14 | Massachusetts Institute Of Technology | Systèmes oligonucléotidiques pour une administration intracellulaire ciblée |
| US20080081051A1 (en) * | 2006-09-28 | 2008-04-03 | Robert Sabin | Method of manufacturing anti-tumor and anti-viral compositions |
| US20100303723A1 (en) * | 2006-11-20 | 2010-12-02 | Massachusetts Institute Of Technology | Drug delivery systems using fc fragments |
| WO2008098165A2 (fr) * | 2007-02-09 | 2008-08-14 | Massachusetts Institute Of Technology | Bioréacteur oscillant pour la culture de cellules |
| WO2008124634A1 (fr) | 2007-04-04 | 2008-10-16 | Massachusetts Institute Of Technology | Micelles inverses encapsulées par un polymère |
| JP2010523595A (ja) | 2007-04-04 | 2010-07-15 | マサチューセッツ インスティテュート オブ テクノロジー | ポリ（アミノ酸）ターゲッティング部分 |
| ES2402334T3 (es) | 2007-08-02 | 2013-04-30 | Gilead Biologics, Inc | Procedimientos y composiciones para el tratamiento y el diagnóstico de la fibrosis |
| EP3424525A1 (fr) | 2007-10-12 | 2019-01-09 | Massachusetts Institute Of Technology | Nanotechnologie de vaccin |
| US8497122B2 (en) | 2008-04-11 | 2013-07-30 | Washington University | Biomarkers for Niemann-pick C disease and related disorders |
| US8343498B2 (en) * | 2008-10-12 | 2013-01-01 | Massachusetts Institute Of Technology | Adjuvant incorporation in immunonanotherapeutics |
| US8591905B2 (en) | 2008-10-12 | 2013-11-26 | The Brigham And Women's Hospital, Inc. | Nicotine immunonanotherapeutics |
| US8343497B2 (en) | 2008-10-12 | 2013-01-01 | The Brigham And Women's Hospital, Inc. | Targeting of antigen presenting cells with immunonanotherapeutics |
| US8277812B2 (en) * | 2008-10-12 | 2012-10-02 | Massachusetts Institute Of Technology | Immunonanotherapeutics that provide IgG humoral response without T-cell antigen |
| US9107935B2 (en) * | 2009-01-06 | 2015-08-18 | Gilead Biologics, Inc. | Chemotherapeutic methods and compositions |
| JP2012524780A (ja) * | 2009-04-21 | 2012-10-18 | セレクタ バイオサイエンシーズ インコーポレーテッド | Ｔｈ１バイアス応答をもたらす免疫ナノ治療薬（Ｉｍｍｕｎｏｎａｎｏｔｈｅｒａｐｅｕｔｉｃｓ） |
| US8609927B2 (en) | 2009-05-28 | 2013-12-17 | Trustees Of Dartmouth College | Caveolin 1-reporter protein knock-in mouse |
| CN102711821A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 治疗方法和组合物 |
| CN102711820A (zh) * | 2009-08-21 | 2012-10-03 | 吉联亚生物科技有限公司 | 治疗肺纤维化疾病的方法和组合物 |
| WO2011022670A1 (fr) * | 2009-08-21 | 2011-02-24 | Arresto Biosciences, Inc | Essais de criblage in vivo |
| SG178845A1 (en) | 2009-08-21 | 2012-04-27 | Gilead Biologics Inc | Catalytic domains from lysyl oxidase and loxl2 |
| US20110207144A1 (en) * | 2009-08-21 | 2011-08-25 | Derek Marshall | In vitro screening assays |
| BR112012019693A2 (pt) | 2010-02-04 | 2017-06-20 | Gilead Biologics Inc | anticorpos que se ligam à lisil oxidase-like 2 (loxl2) e métodos de uso para eles. |
| EP2548862B1 (fr) | 2010-03-15 | 2016-06-08 | Ube Industries, Ltd. | Procédé de fabrication d'un composé amide |
| EP2544003A1 (fr) * | 2011-07-07 | 2013-01-09 | CNIC, Fundacion Centro Nacional de Investigaciones Cardiovasculares Carlos III | Cavéoline-1 dans des fibroblastes liés aux tumeurs en tant que biomarqueur de la progression de la tumeur |
| NZ712903A (en) | 2013-03-18 | 2018-07-27 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
| US10869940B2 (en) | 2015-06-12 | 2020-12-22 | The Board Of Trustees Of The Leland Stanford Junior University | Targeted photoacoustic compounds, formulations, and uses thereof |
| US11097134B2 (en) * | 2019-05-16 | 2021-08-24 | Academia Sinica | Caveolin-1 antibody for use in treating brain inflammation and injury and improving functional recovery |
| WO2022266413A1 (fr) * | 2021-06-17 | 2022-12-22 | Mayo Foundation For Medical Education And Research | Évaluation et traitement du cancer de la prostate |
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| US4317818A (en) | 1976-05-10 | 1982-03-02 | Richardson-Merrell Inc. | Method of treating prostatic carcinoma |
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| IL108449A (en) | 1993-01-26 | 2011-09-27 | Weiner David B | Assemblies and methods for delivery of genetic material |
| GB9311130D0 (en) | 1993-05-28 | 1993-07-14 | Isis Innovation | Tumor metastasis gene |
| WO1995019369A1 (fr) | 1994-01-14 | 1995-07-20 | Vanderbilt University | Procede de detection et de traitement du cancer du sein |
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| AU705945B2 (en) | 1995-09-08 | 1999-06-03 | Beth Israel Deaconess Medical Center | Isolation of microdomains of caveolae and GPI-anchored proteins |
| US5783182A (en) | 1996-01-30 | 1998-07-21 | Baylor College Of Medicine | Method for identifying metastatic sequences |
| WO1997018454A2 (fr) | 1995-11-16 | 1997-05-22 | Baylor College Of Medicine | Procede d'identification de sequences metastasiques |
| US5834234A (en) * | 1996-05-29 | 1998-11-10 | Immunogen, Inc. | Apoptosis associated protein Bbk |
| CA2308565A1 (fr) | 1997-11-05 | 1999-05-14 | Baylor College Of Medicine | Sequences pour cibler les cellules metastatiques |
-
1998
- 1998-11-05 CA CA002308565A patent/CA2308565A1/fr not_active Abandoned
- 1998-11-05 US US09/186,184 patent/US6252058B1/en not_active Expired - Lifetime
- 1998-11-05 WO PCT/US1998/023542 patent/WO1999022773A2/fr not_active Ceased
- 1998-11-05 EP EP98956594A patent/EP1029048A2/fr not_active Withdrawn
- 1998-11-05 AU AU13082/99A patent/AU734476B2/en not_active Ceased
-
2001
- 2001-03-05 US US09/797,969 patent/US7029859B2/en not_active Expired - Fee Related
-
2002
- 2002-05-21 US US10/151,055 patent/US20030003103A1/en not_active Abandoned
-
2003
- 2003-10-22 US US10/690,713 patent/US7666412B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999022773A3 (fr) | 1999-10-14 |
| AU1308299A (en) | 1999-05-24 |
| WO1999022773B1 (fr) | 1999-11-11 |
| US7666412B2 (en) | 2010-02-23 |
| US6252058B1 (en) | 2001-06-26 |
| US20030003103A1 (en) | 2003-01-02 |
| AU734476B2 (en) | 2001-06-14 |
| US7029859B2 (en) | 2006-04-18 |
| US20050036986A1 (en) | 2005-02-17 |
| US20010012890A1 (en) | 2001-08-09 |
| EP1029048A2 (fr) | 2000-08-23 |
| WO1999022773A2 (fr) | 1999-05-14 |
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