CA2309005A1 - Proteine murd et gene de streptococcus pyogenes - Google Patents

Proteine murd et gene de streptococcus pyogenes Download PDF

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Publication number
CA2309005A1
CA2309005A1 CA002309005A CA2309005A CA2309005A1 CA 2309005 A1 CA2309005 A1 CA 2309005A1 CA 002309005 A CA002309005 A CA 002309005A CA 2309005 A CA2309005 A CA 2309005A CA 2309005 A1 CA2309005 A1 CA 2309005A1
Authority
CA
Canada
Prior art keywords
murd
leu
ala
gly
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002309005A
Other languages
English (en)
Inventor
Mohammed El-Sherbeini
Kenny Kin Chung Wong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2309005A1 publication Critical patent/CA2309005A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne le gène murD de Streptococcus pyogenes, ainsi que des protéines murD recombinantes isolées et purifiées. On décrit également des séquences d'acide nucléique codant des protéines murD fonctionnellement actives. On décrit enfin des dosages permettant d'identifier des modulateurs de l'expression de murD et des inhibiteurs de l'activité de murD.
CA002309005A 1997-11-04 1998-10-30 Proteine murd et gene de streptococcus pyogenes Abandoned CA2309005A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6420597P 1997-11-04 1997-11-04
US60/064,205 1997-11-04
PCT/US1998/023054 WO1999023201A1 (fr) 1997-11-04 1998-10-30 PROTEINE MURD ET GENE DE $i(STREPTOCOCCUS PYOGENES)

Publications (1)

Publication Number Publication Date
CA2309005A1 true CA2309005A1 (fr) 1999-05-14

Family

ID=22054281

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309005A Abandoned CA2309005A1 (fr) 1997-11-04 1998-10-30 Proteine murd et gene de streptococcus pyogenes

Country Status (4)

Country Link
EP (1) EP1029033A4 (fr)
JP (1) JP2001521735A (fr)
CA (1) CA2309005A1 (fr)
WO (1) WO1999023201A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999023241A1 (fr) * 1997-11-04 1999-05-14 Merck & Co., Inc. Proteine et gene murd du staphylocoque dore

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5681694A (en) * 1996-06-18 1997-10-28 Eli Lilly And Company Murd protein method and kit for identification of inhibitors
US5929045A (en) * 1997-08-12 1999-07-27 Smithkline Beecham Corporation Recombinant expression of polynucleotides encoding the UDP-N-acetylmuramoylalanine:D-glutamate ligase (MurD) of Streptococcus pneumoniae

Also Published As

Publication number Publication date
EP1029033A1 (fr) 2000-08-23
JP2001521735A (ja) 2001-11-13
WO1999023201A1 (fr) 1999-05-14
EP1029033A4 (fr) 2002-11-20

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Legal Events

Date Code Title Description
FZDE Discontinued