CA2309761A1 - Appauvrissement de la cellule th2, compositions et methodes en rapport - Google Patents

Appauvrissement de la cellule th2, compositions et methodes en rapport Download PDF

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Publication number
CA2309761A1
CA2309761A1 CA002309761A CA2309761A CA2309761A1 CA 2309761 A1 CA2309761 A1 CA 2309761A1 CA 002309761 A CA002309761 A CA 002309761A CA 2309761 A CA2309761 A CA 2309761A CA 2309761 A1 CA2309761 A1 CA 2309761A1
Authority
CA
Canada
Prior art keywords
ccr8
cells
binding
antagonist
antibodies
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002309761A
Other languages
English (en)
Inventor
Hortensia Soto-Trejo
Joseph A. Hedrick
Monica Napolitano
Albert Zlotnik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp & Dohme LLC
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2309761A1 publication Critical patent/CA2309761A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Cette invention, qui a trait à des compositions de liaison se liant de manière sélective à un marqueur présent de manière spécifique sur des cellules Th2, concerne également diverses méthodes d'utilisation de ces compositions. La méthode fait, notamment, usage du fait que le récepteur de chémokine CCR8 est exprimé de manière sélective dans le sous-ensemble de cellule Th2. La composition de liaison est, de préférence, un anticorps monoclonal spécifique de CCR8.
CA002309761A 1997-11-13 1998-11-12 Appauvrissement de la cellule th2, compositions et methodes en rapport Abandoned CA2309761A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6539297P 1997-11-13 1997-11-13
US60/065,392 1997-11-13
PCT/US1998/023240 WO1999025734A2 (fr) 1997-11-13 1998-11-12 APPAUVRISSEMENT DE LA CELLULE Th2, COMPOSITIONS ET METHODES EN RAPPORT

Publications (1)

Publication Number Publication Date
CA2309761A1 true CA2309761A1 (fr) 1999-05-27

Family

ID=22062409

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002309761A Abandoned CA2309761A1 (fr) 1997-11-13 1998-11-12 Appauvrissement de la cellule th2, compositions et methodes en rapport

Country Status (7)

Country Link
EP (1) EP1030865A2 (fr)
JP (1) JP2001523446A (fr)
AR (1) AR016681A1 (fr)
AU (1) AU1373099A (fr)
CA (1) CA2309761A1 (fr)
WO (1) WO1999025734A2 (fr)
ZA (1) ZA9810371B (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7157418B1 (en) 1998-07-22 2007-01-02 Osprey Pharmaceuticals, Ltd. Methods and compositions for treating secondary tissue damage and other inflammatory conditions and disorders
US6416954B1 (en) * 1999-02-08 2002-07-09 Schering Corporation Modulating Th2 cell levels via vMIP-I/CCR8 interaction
AU2001236802A1 (en) * 2000-02-10 2001-08-20 Schering Corporation Novel uses of mammalian ccr8 receptors and related reagents
US6762341B2 (en) 2000-02-10 2004-07-13 Schering Corporation Uses of mammalian CCR8 receptors and related reagents
WO2003096020A2 (fr) * 2002-05-13 2003-11-20 Bayer Healthcare Ag Diagnostic et traitement de maladies liees au recepteur 8 des chimiokines (ccr8)
WO2007044756A2 (fr) * 2005-10-11 2007-04-19 Icos Corporation Anticorps monoclonaux reconnaissant le ccr8 humain
WO2014082993A2 (fr) * 2012-11-30 2014-06-05 Galapagos Nv Cibles moléculaires et composés, et procédés d'identification de ceux-ci, utiles dans la régulation à la baisse de la réponse th2
CN109715653A (zh) * 2016-05-16 2019-05-03 驰科迈博有限责任公司 肿瘤浸润调节性t细胞中被选择性地去调节的标志物
BR112021011431A2 (pt) * 2018-12-27 2021-11-23 Univ Osaka Anticorpo monoclonal ou um fragmento de anticorpo do mesmo que se liga ao ccr8, seu uso, bem como composição farmacêutica, polinucleotídeo, vetor de expressão e kit
TWI890283B (zh) 2020-02-14 2025-07-11 美商基利科學股份有限公司 結合ccr8之抗體及融合蛋白及其用途
JPWO2023219147A1 (fr) * 2022-05-13 2023-11-16

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4364932A (en) * 1979-09-18 1982-12-21 Ortho Pharmaceutical Corporation Monoclonal antibody to human cytotoxic and suppressor T cells and methods of preparing same
PT843557E (pt) * 1995-07-21 2003-03-31 Applied Research Systems Metodos para detectar indentificar isolar e etiquetar e abordar selectivamente linfocitos th1 por intermedio da proteina lag-3
DE69734141T2 (de) * 1996-06-05 2006-07-13 Bml Inc. PROTEIN, DAS FÜR MENSCHLICHE Th2-ZELLEN SPEZIFISCH IST, DAFÜR KODIERENDES GEN UND KORRESPONDIERENDE TRANSFORMANTE, REKOMBINANTER VEKTOR UND MONOKLONALER ANTKÖRPER

Also Published As

Publication number Publication date
ZA9810371B (en) 1999-08-30
AU1373099A (en) 1999-06-07
WO1999025734A2 (fr) 1999-05-27
AR016681A1 (es) 2001-07-25
EP1030865A2 (fr) 2000-08-30
WO1999025734A3 (fr) 1999-07-15
JP2001523446A (ja) 2001-11-27

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued