CA2312366A1 - Inhibiteurs de la farnesyl-proteine transferase - Google Patents

Inhibiteurs de la farnesyl-proteine transferase Download PDF

Info

Publication number
CA2312366A1
CA2312366A1 CA002312366A CA2312366A CA2312366A1 CA 2312366 A1 CA2312366 A1 CA 2312366A1 CA 002312366 A CA002312366 A CA 002312366A CA 2312366 A CA2312366 A CA 2312366A CA 2312366 A1 CA2312366 A1 CA 2312366A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
alkyl
aryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002312366A
Other languages
English (en)
Inventor
Terrence M. Ciccarone
Wasyl Halczenko
John H. Hutchinson
William C. Lumma, Jr.
Gerald E. Stokker
Craig A. . Stump
Theresa M. Williams
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/985,320 external-priority patent/US5977134A/en
Application filed by Individual filed Critical Individual
Publication of CA2312366A1 publication Critical patent/CA2312366A1/fr
Abandoned legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des composés qui inhibent la farnésyl-protéine transférase (Ftase) et la farnélysation de la protéine Ras oncogène. L'invention concerne également des composés chimiothérapeutiques contenant les composés de l'invention et des procédés d'inhibition de la farnésyl-protéine transférase et la farnélysation de la protéine Ras oncogène.
CA002312366A 1997-12-04 1998-11-30 Inhibiteurs de la farnesyl-proteine transferase Abandoned CA2312366A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/985,320 US5977134A (en) 1996-12-05 1997-12-04 Inhibitors of farnesyl-protein transferase
US08/985,320 1997-12-04
PCT/US1998/025352 WO1999028313A1 (fr) 1996-12-05 1998-11-30 Inhibiteurs de la farnesyl-proteine transferase

Publications (1)

Publication Number Publication Date
CA2312366A1 true CA2312366A1 (fr) 1999-06-10

Family

ID=25531371

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002312366A Abandoned CA2312366A1 (fr) 1997-12-04 1998-11-30 Inhibiteurs de la farnesyl-proteine transferase

Country Status (3)

Country Link
EP (1) EP1045843A4 (fr)
AU (1) AU1612099A (fr)
CA (1) CA2312366A1 (fr)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1615895A (en) * 1994-03-31 1995-10-12 Bristol-Myers Squibb Company Imidazole-containing inhibitors of farnesyl protein transferase
CA2249641A1 (fr) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibiteurs de farnesyl-proteine transferase
JP2000507591A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤
WO1997036898A1 (fr) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibiteurs de la farnesyl-proteine transferase
CA2249665A1 (fr) * 1996-04-03 1997-10-09 Merck & Co., Inc. Inhibiteurs de la farnesyl-proteine transferase
JP2000507590A (ja) * 1996-04-03 2000-06-20 メルク エンド カンパニー インコーポレーテッド ファルネシル―タンパク質トランスフェラーゼ阻害剤

Also Published As

Publication number Publication date
AU1612099A (en) 1999-06-16
EP1045843A4 (fr) 2001-10-24
EP1045843A1 (fr) 2000-10-25

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Legal Events

Date Code Title Description
FZDE Discontinued