CA2315260A1 - Condensations aldol effectuees a l'aide d'anticorps catalytiques - Google Patents

Condensations aldol effectuees a l'aide d'anticorps catalytiques Download PDF

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Publication number
CA2315260A1
CA2315260A1 CA002315260A CA2315260A CA2315260A1 CA 2315260 A1 CA2315260 A1 CA 2315260A1 CA 002315260 A CA002315260 A CA 002315260A CA 2315260 A CA2315260 A CA 2315260A CA 2315260 A1 CA2315260 A1 CA 2315260A1
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CA
Canada
Prior art keywords
aldol
ketone
reaction
antibody
beta
Prior art date
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Abandoned
Application number
CA002315260A
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English (en)
Inventor
Richard A. Lerner
Carlos F. Barbas, Iii
Guofu Zhong
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Scripps Research Institute
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Individual
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Publication of CA2315260A1 publication Critical patent/CA2315260A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Cette invention concerne des anticorps catalytiques, comprenant 38C2 et 33F12, qui sont capables de catalyser efficacement une grande diversité de réactions aldol intermoléculaires cétone-cétone, cétone-aldéhyde, aldéhyde-cétone, et aldéhyde-aldéhyde, et dans certains cas de catalyser la déshydratation subséquente pour produire des produits de condensation aldol. On a également défini un certain nombre de réactions aldol intramoléculaires. La catalyse de toutes les réactions aldol intramoléculaires examinées a eu pour résultat les produits de condensation correspondants.
CA002315260A 1997-12-18 1998-12-18 Condensations aldol effectuees a l'aide d'anticorps catalytiques Abandoned CA2315260A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6804997P 1997-12-18 1997-12-18
US60/068,049 1997-12-18
PCT/US1998/026942 WO1999031263A1 (fr) 1997-12-18 1998-12-18 Condensations aldol effectuees a l'aide d'anticorps catalytiques

Publications (1)

Publication Number Publication Date
CA2315260A1 true CA2315260A1 (fr) 1999-06-24

Family

ID=22080105

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002315260A Abandoned CA2315260A1 (fr) 1997-12-18 1998-12-18 Condensations aldol effectuees a l'aide d'anticorps catalytiques

Country Status (5)

Country Link
EP (1) EP1038018A4 (fr)
JP (1) JP2002508188A (fr)
AU (1) AU1927799A (fr)
CA (1) CA2315260A1 (fr)
WO (1) WO1999031263A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2121611B1 (fr) * 2007-03-19 2015-04-15 DSM IP Assets B.V. Composés de filtres UV à base de alpha,beta-dihydroxycétones
AU2009234373B2 (en) 2008-04-09 2015-09-24 Cornell University Coferons and methods of making and using them
CA2774476A1 (fr) 2009-10-07 2011-04-14 Francis Barany Coferons et procedes de fabrication et d'utilisation de ceux-ci

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5733757A (en) * 1995-12-15 1998-03-31 The Scripps Research Institute Aldolase catalytic antibody

Also Published As

Publication number Publication date
EP1038018A4 (fr) 2004-10-13
AU1927799A (en) 1999-07-05
JP2002508188A (ja) 2002-03-19
EP1038018A1 (fr) 2000-09-27
WO1999031263A1 (fr) 1999-06-24

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