CA2330104A1 - Creation de tissus tridimensionnels - Google Patents

Creation de tissus tridimensionnels Download PDF

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Publication number
CA2330104A1
CA2330104A1 CA002330104A CA2330104A CA2330104A1 CA 2330104 A1 CA2330104 A1 CA 2330104A1 CA 002330104 A CA002330104 A CA 002330104A CA 2330104 A CA2330104 A CA 2330104A CA 2330104 A1 CA2330104 A1 CA 2330104A1
Authority
CA
Canada
Prior art keywords
cells
vascularized
providing
constructs
dimensional tissue
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002330104A
Other languages
English (en)
Inventor
Craig R. Halberstadt
Walter D. Holder, Jr.
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Charlotte Mecklenburg Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Charlotte Mecklenburg Hospital filed Critical Charlotte Mecklenburg Hospital
Publication of CA2330104A1 publication Critical patent/CA2330104A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3839—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by the site of application in the body
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0068—General culture methods using substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/54—Collagen; Gelatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/74—Alginate

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Microbiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Botany (AREA)
  • Materials For Medical Uses (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

L'invention concerne un procédé d'apport d'un tissu tridimensionnel vascularisé dans un sujet vivant. Le procédé consiste à) à créer à partir d'une matière biocompatible capable de support l'adhésion, la croissance et la migration cellulaires, une construction poreuse contenant des cellules à transplanter et b) à administrer la construction dans une zone d'intérêt dans le sujet vivant pour former un tissu tridimensionnel vascularisé. La construction préférentielle présente une dimension dont la distance de la surface la plus externe au centre de la construction mesure entre environ 50 µm et environ 500 µm. La construction préférentielle présente aussi une structure poreuse interconnectée dont la granulométrie des pores est de l'ordre d'environ 10 µm ne dépassant pas 300µm. Les cellules contenues dans la construction préférentielle ne dépassent pas une distance de 250 µm à partir de la surface externe de la construction.
CA002330104A 1998-04-09 1999-04-09 Creation de tissus tridimensionnels Abandoned CA2330104A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5861998A 1998-04-09 1998-04-09
US09/058,619 1998-04-09
PCT/US1999/007816 WO1999052356A1 (fr) 1998-04-09 1999-04-09 Creation de tissus tridimensionnels

Publications (1)

Publication Number Publication Date
CA2330104A1 true CA2330104A1 (fr) 1999-10-21

Family

ID=22017933

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002330104A Abandoned CA2330104A1 (fr) 1998-04-09 1999-04-09 Creation de tissus tridimensionnels

Country Status (5)

Country Link
EP (1) EP1069822A1 (fr)
JP (1) JP2002511284A (fr)
AU (1) AU3552099A (fr)
CA (1) CA2330104A1 (fr)
WO (1) WO1999052356A1 (fr)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004201641B2 (en) * 1999-04-30 2007-04-19 The Charles Stark Draper Laboratory, Inc. Fabrication of Vascularized Tissue Using Microfabricated Two-Dimensional Molds
JP2002542883A (ja) * 1999-04-30 2002-12-17 マサチューセッツ ジェネラル ホスピタル 微細加工した２次元鋳型を用いる血管新生組織の加工
DE19952847B4 (de) * 1999-10-01 2006-03-23 Minuth, Will, Prof. Dr. Vorrichtung zum Kultivieren und/oder Differenzieren und/oder Halten von Zellen und/oder Geweben
ATE355083T1 (de) * 1999-12-08 2006-03-15 Vercell Biotechnology Bv Kit aus polyakrylamidgel zur herstellung einer kapsel im gewebe eines säugetierorganismus und tierischen allogenen oder xenogenen zellen , zur behandlung von onkologischen krankheiten und der diabetes mellitus
DE10191512D2 (de) 2000-04-11 2003-03-13 Univ Heidelberg Umhüllungen und Folien aus Poly-Tri-Fluor-Ethoxypolyphosphazen
US7776021B2 (en) 2000-04-28 2010-08-17 The Charles Stark Draper Laboratory Micromachined bilayer unit for filtration of small molecules
DE10100961B4 (de) 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
DE50111147D1 (de) * 2001-02-13 2006-11-16 Corlife Gbr Bioartifizielle, primär vaskularisierte Gewebematrix und bioartifizielles, primär vaskularisiertes Gewebe
WO2002078439A2 (fr) * 2001-03-30 2002-10-10 The Arizona Board Of Regents On Behalf Of The University Of Arizona Constructions prevascularisees d'implantation destinees a fournir une perfusion sanguine
US7217570B2 (en) 2001-08-23 2007-05-15 The Wistar Institute Of Anatomy And Biology Organotypic intestinal culture and methods of use thereof
DE10392444T5 (de) * 2002-03-28 2005-05-25 Japan As Represented By President Of National Cardiovascular Center, Suita-Shi Stützgerüst für die Gewebsverarbeitung, künstliches Blutgefäß, Manschette und biologisches Implantat abdeckendes Glied
EP1589814B1 (fr) 2003-01-16 2009-08-12 The General Hospital Corporation Utilisation de systemes microfabriques tridimensionnels du genie tissulaire pour applications pharmacologiques
WO2004072104A2 (fr) * 2003-02-11 2004-08-26 Northwestern University Procedes et matieres pour revetements de surface nanocristallins et liaison de nanofibres d'amphiphiles peptidiques sur ceux-ci
AU2003242464A1 (en) * 2003-06-18 2005-01-04 Hokkaido Technology Licensing Office Co., Ltd. Material for cell adhesion and proliferation
AU2004305574B2 (en) * 2003-12-10 2010-08-26 Cellular Bioengineering, Inc. Methods and composition for soft tissue feature reconstruction
KR20060114366A (ko) * 2004-02-09 2006-11-06 인디애나 유니버시티 리서치 앤드 테크놀로지 코포레이션 클론원성 내피 전구 세포의 분리, 팽창 및 용도
US20070233274A1 (en) * 2004-04-12 2007-10-04 Hideyuki Miyake Artificial Tissue and Process for Producing the Same
JP4303643B2 (ja) 2004-06-01 2009-07-29 育男 森田 人工組織体およびその製造方法
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
PT2347775T (pt) * 2005-12-13 2020-07-14 The President And Fellows Of Harvard College Estruturas em andaime para transplante celular
WO2007087402A2 (fr) * 2006-01-24 2007-08-02 Brown University Dispositif et procédé d'agrégation et d'encapsulation cellulaires
US7922764B2 (en) 2006-10-10 2011-04-12 Celonova Bioscience, Inc. Bioprosthetic heart valve with polyphosphazene
EP2082030A2 (fr) 2006-10-20 2009-07-29 Keracure, Inc. Dispositifs à cellules mise en culture sur des supports flexibles
US8080418B2 (en) 2007-03-09 2011-12-20 Corning Incorporated Method of making a three dimensional cell culture matrix
JP5024823B2 (ja) * 2007-05-30 2012-09-12 独立行政法人産業技術総合研究所 細胞運動性評価セルチップ
WO2009048314A1 (fr) * 2007-10-08 2009-04-16 Sureshan Sivananthan Matrice pouvant être mise à l'échelle pour la culture in vivo d'os et de cartilage
US20110306110A1 (en) * 2008-12-12 2011-12-15 The University Of Tokyo Method for three-dimensional hierarchical cell co-culture
US8501476B2 (en) 2009-10-07 2013-08-06 Brown University Assays and methods for fusing cell aggregates to form proto-tissues
US9675561B2 (en) 2011-04-28 2017-06-13 President And Fellows Of Harvard College Injectable cryogel vaccine devices and methods of use thereof
US9468680B2 (en) 2011-09-22 2016-10-18 Brown University Differential effects of drugs on transport in a multi-layer 3D spheroid model
US9243278B2 (en) 2011-09-22 2016-01-26 Brown University Mechanotransduction by the synergistic action of heterotypic cell interactions
CN104244929B (zh) 2012-04-16 2017-04-05 哈佛学院董事会 用于调节免疫反应的介孔二氧化硅组合物
JP7348708B2 (ja) 2014-04-30 2023-09-21 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 組み合わせワクチン装置および癌細胞を殺滅する方法
HK1247861A1 (zh) 2015-01-30 2018-10-05 President And Fellows Of Harvard College 用於癌症治疗的肿瘤周围和肿瘤内部材料
WO2017043489A1 (fr) 2015-09-11 2017-03-16 富士フイルム株式会社 Procédé de production d'une structure en gélatine et système de production d'une structure en gélatine
EP3411475B1 (fr) 2016-02-06 2025-08-27 President and Fellows of Harvard College Régénération de la niche hématopoïétique pour reconstituer l'immunité
CN115404196A (zh) 2016-07-13 2022-11-29 哈佛学院院长等 抗原呈递细胞模拟支架及其制备和使用方法
CN110418651A (zh) 2016-08-02 2019-11-05 哈佛学院院长等 用于调节免疫应答的生物材料
WO2020061129A1 (fr) 2018-09-19 2020-03-26 President And Fellows Of Harvard College Compositions et procédés de marquage et de modulation de cellules in vitro et in vivo
WO2021061837A1 (fr) 2019-09-23 2021-04-01 President And Fellows Of Harvard College Vaccin sans antigène à base de biomatériau et son utilisation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5716404A (en) * 1994-12-16 1998-02-10 Massachusetts Institute Of Technology Breast tissue engineering

Also Published As

Publication number Publication date
JP2002511284A (ja) 2002-04-16
WO1999052356A1 (fr) 1999-10-21
EP1069822A1 (fr) 2001-01-24
AU3552099A (en) 1999-11-01

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