CA2332786A1 - Identification d'epitopes dr de restriction largement reactifs - Google Patents

Identification d'epitopes dr de restriction largement reactifs Download PDF

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Publication number
CA2332786A1
CA2332786A1 CA002332786A CA2332786A CA2332786A1 CA 2332786 A1 CA2332786 A1 CA 2332786A1 CA 002332786 A CA002332786 A CA 002332786A CA 2332786 A CA2332786 A CA 2332786A CA 2332786 A1 CA2332786 A1 CA 2332786A1
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Prior art keywords
peptide
peptides
binding
composition
epitope
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Abandoned
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CA002332786A
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Alessandro Sette
Scott Southwood
John Sidney
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Epimmune Inc
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Individual
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A—HUMAN NECESSITIES
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    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16241—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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Abstract

La présente invention s'appuie, au moins en partie, sur la découverte et l'utilisation d'épitopes peptidiques immunogènes spécifiques pour diverses molécules DR HLA de la classe II, représentatives de la population mondiale. Ces peptides renferment un épitope, ou un analogue de celui-ci, qui se fixe à une molécule HLA de la classe II selon une capacité IC¿50? inférieure ou égale à 1000 nM.
CA002332786A 1998-05-29 1999-05-28 Identification d'epitopes dr de restriction largement reactifs Abandoned CA2332786A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8719298P 1998-05-29 1998-05-29
US60/087,192 1998-05-29
PCT/US1999/012066 WO1999061916A1 (fr) 1998-05-29 1999-05-28 Identification d'epitopes dr de restriction largement reactifs

Publications (1)

Publication Number Publication Date
CA2332786A1 true CA2332786A1 (fr) 1999-12-02

Family

ID=22203638

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002332786A Abandoned CA2332786A1 (fr) 1998-05-29 1999-05-28 Identification d'epitopes dr de restriction largement reactifs

Country Status (5)

Country Link
EP (1) EP1080370A4 (fr)
JP (1) JP2002516824A (fr)
AU (1) AU4224499A (fr)
CA (1) CA2332786A1 (fr)
WO (1) WO1999061916A1 (fr)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9340577B2 (en) 1992-08-07 2016-05-17 Epimmune Inc. HLA binding motifs and peptides and their uses
GB9826143D0 (en) 1998-11-27 1999-01-20 Ludwig Inst Cancer Res Tumour rejection antigens
US7462354B2 (en) 1999-12-28 2008-12-09 Pharmexa Inc. Method and system for optimizing minigenes and peptides encoded thereby
AU2001253029A1 (en) * 2000-03-30 2001-10-15 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services T-cell epitope of mage-12 and related nucleic acids, vectors, cells, compositions and methods of inducing an immune response to cancer
US7608683B2 (en) 2000-08-09 2009-10-27 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
EP1652856A1 (fr) * 2000-08-09 2006-05-03 The Regents of The University of California San Diego Peptides dérivés de protéines de stress et méthodes d'utilisation
US6989146B2 (en) * 2000-08-09 2006-01-24 The Regents Of The University Of California Stress proteins and peptides and methods of use thereof
US20060177416A1 (en) 2003-10-14 2006-08-10 Medivas, Llc Polymer particle delivery compositions and methods of use
AU2002322009A1 (en) 2001-05-18 2002-12-03 Mayo Foundation For Medical Education And Research Chimeric antigen-specific t cell-activating polypeptides
US20060222656A1 (en) 2005-04-01 2006-10-05 University Of Maryland, Baltimore MAGE-A3/HPV 16 peptide vaccines for head and neck cancer
AU2003295189A1 (en) * 2002-12-17 2004-07-09 Fondazione Centro San Raffaele Del Monte Tabor Carcinoembryonic antigen-specific immunodominant epitope recognized by cd4+t cells and uses thereof
CN1798569A (zh) * 2003-06-02 2006-07-05 莫西亚药物公司 用于治疗1型糖尿病的治疗性疫苗组合物
JP4956019B2 (ja) * 2005-03-02 2012-06-20 パナソニック株式会社 点灯ユニット及びランプ
JP5192384B2 (ja) 2005-09-22 2013-05-08 メディバス エルエルシー ビス−（α−アミノ）−ジオール−ジエステル含有ポリ（エステルアミド）およびポリ（エステルウレタン）組成物および使用の方法
ES2310072B1 (es) * 2005-12-23 2009-11-16 Proyecto De Biomedicina Cima, S.L. Nuevos peptidos determinantes antigenicos t colaboradores (/dth).
JP2009525341A (ja) * 2006-01-31 2009-07-09 メディバス エルエルシー ワクチン送達組成物および使用法
FR2903605A1 (fr) 2006-07-12 2008-01-18 Sanofi Pasteur Sa Methode d'immunisation contre les quatres serotypes de la dengue
FR2906724B1 (fr) 2006-10-04 2009-03-20 Sanofi Pasteur Sa Methode d'immunisation contre les 4 serotypes de la dengue.
FR2909286B1 (fr) 2006-12-01 2012-06-08 Sanofi Pasteur Methode d'immunisation contre les 4 serotypes de la dengue
JP2011502484A (ja) * 2007-11-01 2011-01-27 メイヨ・ファウンデーション・フォー・メディカル・エデュケーション・アンド・リサーチ Ｈｌａ−ｄｒ結合性ペプチドおよびそれらの使用
EP2315771A4 (fr) * 2008-07-11 2012-02-01 Sloan Kettering Inst Cancer Constructions glycopeptidiques, et leurs utilisations
EP2391635B1 (fr) * 2009-01-28 2017-04-26 Epimmune Inc. Polypeptides de liaison de pan-dr et leurs utilisations
CN107617110A (zh) * 2009-08-26 2018-01-23 西莱克塔生物科技公司 诱导t细胞辅助的组合物
EP2496255A4 (fr) 2009-11-05 2014-03-26 Mercia Pharma Inc Vaccin antigrippal avec adjuvant nanoparticulaire
US9493580B2 (en) 2010-06-11 2016-11-15 Sloan-Kettering Institute For Cancer Research Multivalent glycopeptide constructs and uses thereof
US9873765B2 (en) 2011-06-23 2018-01-23 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
US9963549B2 (en) 2011-06-23 2018-05-08 Dsm Ip Assets, B.V. Biodegradable polyesteramide copolymers for drug delivery
WO2013123424A1 (fr) 2012-02-17 2013-08-22 Mayo Foundation For Medical Education And Research Procédés et matériels pour la génération de lymphocytes t cd8+ ayant la capacité de reconnaître des cellules cancéreuses exprimant un polypeptide her2/neu
EP3233067B1 (fr) 2014-12-18 2019-11-06 DSM IP Assets B.V. Système d'administration de médicament pour délivrer des médicaments sensibles à l'acide
US12577398B2 (en) 2019-11-12 2026-03-17 Dsm Ip Assets B.V. Polyesteramide copolymers possessing high glass transition temperatures

Also Published As

Publication number Publication date
EP1080370A4 (fr) 2003-07-30
EP1080370A1 (fr) 2001-03-07
AU4224499A (en) 1999-12-13
JP2002516824A (ja) 2002-06-11
WO1999061916A1 (fr) 1999-12-02

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