CA2333157A1 - Nouveaux composes d'imidazole substitue - Google Patents
Nouveaux composes d'imidazole substitue Download PDFInfo
- Publication number
- CA2333157A1 CA2333157A1 CA002333157A CA2333157A CA2333157A1 CA 2333157 A1 CA2333157 A1 CA 2333157A1 CA 002333157 A CA002333157 A CA 002333157A CA 2333157 A CA2333157 A CA 2333157A CA 2333157 A1 CA2333157 A1 CA 2333157A1
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- Prior art keywords
- alkyl
- heterocyclic
- hydrogen
- disease
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Abstract
L'invention concerne de nouveaux composés d'imidazole 1,4,5-substitué et des compositions destinées à être utilisées comme inhibiteurs d'ERK/MAP dans des affections induites par ERK/MAP.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8664598P | 1998-05-26 | 1998-05-26 | |
| US60/086,645 | 1998-05-26 | ||
| PCT/US1999/011455 WO1999061440A1 (fr) | 1998-05-26 | 1999-05-25 | Nouveaux composes d'imidazole substitue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2333157A1 true CA2333157A1 (fr) | 1999-12-02 |
Family
ID=22199934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002333157A Abandoned CA2333157A1 (fr) | 1998-05-26 | 1999-05-25 | Nouveaux composes d'imidazole substitue |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1082320A4 (fr) |
| JP (1) | JP2002516325A (fr) |
| CA (1) | CA2333157A1 (fr) |
| WO (1) | WO1999061440A1 (fr) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2294057A1 (fr) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | Nouveaux composes de pyrazole et de pyrazoline substitues |
| AU8154998A (en) | 1997-06-19 | 1999-01-04 | Smithkline Beecham Corporation | Novel aryloxy substituted pyrimidine imidazole compounds |
| US7301021B2 (en) | 1997-07-02 | 2007-11-27 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6489325B1 (en) | 1998-07-01 | 2002-12-03 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| US6562832B1 (en) | 1997-07-02 | 2003-05-13 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| WO1999017776A1 (fr) | 1997-10-08 | 1999-04-15 | Smithkline Beecham Corporation | Nouveaux composes substitues de cycloalcenyle |
| US6858617B2 (en) | 1998-05-26 | 2005-02-22 | Smithkline Beecham Corporation | Substituted imidazole compounds |
| JP2003525201A (ja) | 1998-08-20 | 2003-08-26 | スミスクライン・ビーチャム・コーポレイション | 新規な置換トリアゾール化合物 |
| WO2000025791A1 (fr) | 1998-11-04 | 2000-05-11 | Smithkline Beecham Corporation | Pyrazines substitues pyridin-4-yle ou pyrimidin-4-yle |
| AU776788C (en) * | 1998-12-16 | 2005-10-27 | Warner-Lambert Company | Treatment of arthritis with MEK inhibitors |
| AU1781601A (en) | 1999-11-23 | 2001-06-04 | Smithkline Beecham Corporation | 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors |
| ATE305787T1 (de) | 1999-11-23 | 2005-10-15 | Smithkline Beecham Corp | 3,4-dihydro-(1h)chinazolin-2-on-verbindungen als csbp/p39-kinase-inhibitoren |
| EP1233951B1 (fr) | 1999-11-23 | 2005-06-01 | SmithKline Beecham Corporation | Composes de 3,4-dihydro-(1h)quinazolin-2-one utilises comme inhibiteurs de kinase csbp/p38 |
| US7235551B2 (en) | 2000-03-02 | 2007-06-26 | Smithkline Beecham Corporation | 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases |
| ATE335737T1 (de) | 2000-09-15 | 2006-09-15 | Vertex Pharma | Isoxazole und ihre verwendung als erk-inhibitoren |
| CA2440211A1 (fr) | 2001-03-09 | 2002-09-19 | Pfizer Products Inc. | Composes de benzimidazole anti-inflammatoires |
| EE200300437A (et) | 2001-03-09 | 2004-02-16 | Pfizer Products Inc. | Triasolopüridiinid kui põletikuvastased ained |
| ES2247271T3 (es) | 2001-04-04 | 2006-03-01 | Pfizer Products Inc. | Nuevos benzotriazoles como compuestos antiinflamatorios. |
| DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
| EP1539121A4 (fr) * | 2002-08-29 | 2008-08-13 | Scios Inc | Methode pour favoriser l'osteogenese |
| US7012143B2 (en) | 2002-08-30 | 2006-03-14 | Dombroski Mark A | Cycloalkyl-[4-(difluorophenyl)-oxazol-5-yl]-triazolo-pyridines |
| US7037923B2 (en) | 2002-08-30 | 2006-05-02 | Pfizer, Inc. | Alkyl-[4-(trifluorophenyl)-oxazol-5-yl]-triazolo-pyridines |
| US6949652B2 (en) | 2002-08-30 | 2005-09-27 | Pfizer, Inc. | Crystalline forms of 3-isopropyl-6-[4-(2,5-difluoro-phenyl)-oxazol-5-yl]-[1,2,4]triazolo-[4,3-A]pyridine |
| US7005523B2 (en) | 2002-08-30 | 2006-02-28 | Pfizer Inc. | Cycloalkyl-[4-(trifluorophenyl)-oxazol-5yl]-triazolo-pyridines |
| PA8579601A1 (es) | 2002-08-30 | 2004-05-07 | Pfizer Prod Inc | Compuestos antiinflamatorios de di y trifloruro-triazolo-piridinas |
| DE602004020741D1 (de) * | 2003-02-26 | 2009-06-04 | Kowa Co | Mittel zur behandlung der allergischen kontaktdermatitis |
| US7244441B2 (en) | 2003-09-25 | 2007-07-17 | Scios, Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| US20060166936A1 (en) * | 2004-10-29 | 2006-07-27 | Hayley Binch | Diaminotriazole compounds useful as inhibitors of protein kinases |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1676574A3 (fr) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Procédé favorisant la survie des tissus ou cellules griffées |
| EP1992344A1 (fr) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha comme cible therapeutique pour les maladies associées á une mutation de FGFR3 |
| US8512695B2 (en) | 2008-10-21 | 2013-08-20 | The General Hospital Corporation | Method of preventing fat graft resorption by administering fat-derived cells and poloxamer P 188 |
| US8912142B2 (en) * | 2009-04-01 | 2014-12-16 | The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center | Method of regulating proliferation and differentiation of keratinocyes |
| WO2012019103A2 (fr) | 2010-08-06 | 2012-02-09 | The General Hospital Corporation D/B/A | Système et appareil de traitement cellulaire |
| BR112021017957A2 (pt) | 2019-03-28 | 2021-11-23 | Jiangsu Hengrui Medicine Co | Derivado tienoeterocíclico, método de preparação do mesmo e uso médico do mesmo |
| TW202102505A (zh) | 2019-03-29 | 2021-01-16 | 大陸商江蘇恆瑞醫藥股份有限公司 | 吡咯并雜環類衍生物、其製備方法及其在醫藥上的應用 |
| JP2022534224A (ja) | 2019-05-24 | 2022-07-28 | 江蘇恒瑞医薬股▲ふん▼有限公司 | 置換縮合二環式誘導体、その調製方法、および医薬におけるその適用 |
| WO2022068860A1 (fr) | 2020-09-29 | 2022-04-07 | 江苏恒瑞医药股份有限公司 | Forme cristalline d'un dérivé pyrrolo-hétérocyclique et son procédé de préparation |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5593992A (en) * | 1993-07-16 | 1997-01-14 | Smithkline Beecham Corporation | Compounds |
| WO1998016230A1 (fr) * | 1996-10-17 | 1998-04-23 | Smithkline Beecham Corporation | Procedes permettant d'inhiber de maniere reversible la myelopoiese dans des tissus mammaliens |
-
1999
- 1999-05-25 WO PCT/US1999/011455 patent/WO1999061440A1/fr not_active Ceased
- 1999-05-25 JP JP2000550846A patent/JP2002516325A/ja not_active Withdrawn
- 1999-05-25 EP EP99924480A patent/EP1082320A4/fr not_active Withdrawn
- 1999-05-25 CA CA002333157A patent/CA2333157A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999061440A1 (fr) | 1999-12-02 |
| EP1082320A1 (fr) | 2001-03-14 |
| EP1082320A4 (fr) | 2001-11-21 |
| JP2002516325A (ja) | 2002-06-04 |
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