CA2336781C - Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t - Google Patents
Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t Download PDFInfo
- Publication number
- CA2336781C CA2336781C CA2336781A CA2336781A CA2336781C CA 2336781 C CA2336781 C CA 2336781C CA 2336781 A CA2336781 A CA 2336781A CA 2336781 A CA2336781 A CA 2336781A CA 2336781 C CA2336781 C CA 2336781C
- Authority
- CA
- Canada
- Prior art keywords
- hypericin
- extract
- hypericum
- patient
- type calcium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- SSKVDVBQSWQEGJ-UHFFFAOYSA-N pseudohypericin Natural products C12=C(O)C=C(O)C(C(C=3C(O)=CC(O)=C4C=33)=O)=C2C3=C2C3=C4C(C)=CC(O)=C3C(=O)C3=C(O)C=C(O)C1=C32 SSKVDVBQSWQEGJ-UHFFFAOYSA-N 0.000 title claims abstract description 119
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne une hypéricine inhibant l'activité du canal du calcium de type T. L'extrait d'Hypericum contenant de l'hypéricine inhibe aussi l'activité du canal du calcium de type T. De plus, d'autres produits chimiques contenus dans l'extrait d'Hypericum font preuve d'un effet synergique sur l'hypéricine. En l'occurrence, l'hypéricine ou l'extrait d'Hypericum contenant de hypéricine peut être utilisé(e) comme agent bloquant le canal T. L'extrait d'Hypericum, l'extrait d'autres espèces de l'Hypericum, l'extrait d'autres plantes contenant de l'hypéricine, l'hypéricine, ses dérivés, ses analogues, tels que la pseudohypéricine et d'autres constituants de l'extrait d'Hypericum peuvent être utilisés comme agents thérapeutiques dirigés contre les canaux de calcium de type T pour traiter des maladies associées à l'anomalie du canal T. Font aussi l'objet de cette invention des procédés d'administration de l'hypéricine et de l'extrait d'Hypericum.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9222798P | 1998-07-09 | 1998-07-09 | |
| US60/092,227 | 1998-07-09 | ||
| PCT/US1999/014132 WO2000002455A1 (fr) | 1998-07-09 | 1999-07-09 | Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2336781A1 CA2336781A1 (fr) | 2000-01-20 |
| CA2336781C true CA2336781C (fr) | 2010-12-14 |
Family
ID=22232251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2336781A Expired - Lifetime CA2336781C (fr) | 1998-07-09 | 1999-07-09 | Hypericine et extrait d'hypericum: agents bloquant les canaux de calcium de type c et leur utilisation comme agents therapeutiques diriges contre le canal de calcium de type t |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP1094712A4 (fr) |
| JP (1) | JP2002520260A (fr) |
| KR (1) | KR20010071822A (fr) |
| CN (1) | CN1308492A (fr) |
| AU (1) | AU4958199A (fr) |
| CA (1) | CA2336781C (fr) |
| WO (1) | WO2000002455A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1131063B1 (fr) * | 1998-11-25 | 2003-04-23 | Universitätsklinikum Freiburg | Pommade ou creme a base d'hyperforine |
| AU3744100A (en) * | 1999-03-15 | 2000-10-04 | Shaman Pharmaceuticals, Inc. | Bicyclo(3.3.1)nonenes useful for the treatment of diabetes |
| US20030045449A1 (en) * | 2001-08-15 | 2003-03-06 | Pfizer, Inc. | Pharmaceutical combinations for the treatment of neurodegenerative diseases |
| CN1261111C (zh) * | 2001-09-25 | 2006-06-28 | 北京北大维信生物科技有限公司 | 一种治疗抑郁症口服药的制备方法 |
| DE10213571A1 (de) * | 2002-03-26 | 2003-10-23 | Lichtwer Pharma Ag | Pflanzenextrakte und deren Anwendung |
| WO2004035000A2 (fr) * | 2002-10-17 | 2004-04-29 | Merck & Co., Inc. | Amelioration du sommeil a l'aide d'antagonistes des canaux calciques de type t |
| KR100873400B1 (ko) * | 2002-10-17 | 2008-12-11 | 한국과학기술연구원 | Ｎ-타입 칼슘 채널의 활성을 억제함으로써 우울증을감소시키는 방법 |
| WO2005007124A2 (fr) | 2003-07-23 | 2005-01-27 | Bristol-Myers Squibb Company | Inhibiteurs dihydropyrimidine substituee de la fonction canaux calciques |
| US7166603B2 (en) | 2003-07-23 | 2007-01-23 | Bristol-Myers Squibb Co. | Dihydropyrimidone inhibitors of calcium channel function |
| US7504431B2 (en) | 2004-04-16 | 2009-03-17 | Bristol-Myers Squibb Company | Sulfonyl amide inhibitors of calcium channel function |
| US20100048728A1 (en) * | 2006-08-03 | 2010-02-25 | Hy Biopharma Inc. | Polycyclic dianthraquinones as inhibitors of inflammatory cytokines |
| ES2842289T3 (es) | 2008-02-29 | 2021-07-13 | Vm Therapeutics Llc | Compuestos para tratar el síndrome del dolor y otros trastornos |
| CN103285072B (zh) * | 2012-02-24 | 2015-09-09 | 北京北大维信生物科技有限公司 | 包含金丝桃苷的提取物及其医药用途 |
| CN103751303A (zh) * | 2014-01-18 | 2014-04-30 | 史克勇 | 复方中药 |
| JP6890616B2 (ja) * | 2016-03-01 | 2021-06-18 | ソリジェニックス インコーポレーテッド | 合成ハイペリシンを製造するためのシステムおよび方法 |
| CN108084065B (zh) * | 2017-11-21 | 2020-06-16 | 中国农业科学院兰州畜牧与兽药研究所 | 一种金丝桃素衍生物及其制备方法和应用 |
| JP7210605B2 (ja) * | 2017-12-07 | 2023-01-23 | 江蘇康縁薬業股▲ぶん▼有限公司 | エモジンスクシニルエステル系化合物およびその調製方法と用途 |
| CN110025604A (zh) * | 2019-04-11 | 2019-07-19 | 中国科学院西北高原生物研究所 | 金丝桃素在制备抑制葡萄糖苷酶活性的相关产品中的用途 |
| WO2024043242A1 (fr) * | 2022-08-23 | 2024-02-29 | 国立大学法人九州大学 | Traitement de l'insuffisance cardiaque grâce à l'effet cardiotonique par activation des canaux trpc3/6/7 |
| CN119837851A (zh) * | 2025-03-08 | 2025-04-18 | 华中科技大学同济医学院附属协和医院 | 金丝桃素在制备治疗钙化性主动脉瓣疾病产品中的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE108064T1 (de) * | 1987-10-08 | 1994-07-15 | Andor Bilas | Stoffgemisch zur stabilisierung der stoffwechsel- lage. |
| US5288485A (en) * | 1989-08-31 | 1994-02-22 | Kao Corporation | Vasodilating agent |
| IL92315A (en) * | 1989-11-15 | 1996-12-05 | Yeda Res & Dev | Preparation of Hypericin from Amodin Enron |
| US5514714A (en) * | 1990-08-23 | 1996-05-07 | New York University | Methods and polycyclic aromatic compound containing compositions for treating T-cell-mediated diseases |
| US6576784B1 (en) * | 1993-05-27 | 2003-06-10 | Yeda Research And Development Co. Ltd. | Antiviral agents |
| WO1996030012A1 (fr) * | 1995-03-24 | 1996-10-03 | Defeudis Francis V | Procedes de traitement de conditions associees a des excedents d'oxyde d'azote |
| WO1998027970A2 (fr) * | 1996-12-24 | 1998-07-02 | National Research Council Of Canada | Traitement de maladies ou prevention de dommages cellulaires causes par des radicaux libres contenant de l'oxygene |
| DE19700788A1 (de) * | 1997-01-11 | 1998-07-16 | Michael O Ruepp | Johanniskraut-Trockenextrakte |
-
1999
- 1999-07-09 CA CA2336781A patent/CA2336781C/fr not_active Expired - Lifetime
- 1999-07-09 EP EP99933542A patent/EP1094712A4/fr not_active Withdrawn
- 1999-07-09 AU AU49581/99A patent/AU4958199A/en not_active Abandoned
- 1999-07-09 KR KR1020017000390A patent/KR20010071822A/ko not_active Ceased
- 1999-07-09 JP JP2000558725A patent/JP2002520260A/ja active Pending
- 1999-07-09 CN CN99808429A patent/CN1308492A/zh active Pending
- 1999-07-09 WO PCT/US1999/014132 patent/WO2000002455A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU4958199A (en) | 2000-02-01 |
| EP1094712A4 (fr) | 2004-09-08 |
| JP2002520260A (ja) | 2002-07-09 |
| KR20010071822A (ko) | 2001-07-31 |
| CN1308492A (zh) | 2001-08-15 |
| CA2336781A1 (fr) | 2000-01-20 |
| WO2000002455A1 (fr) | 2000-01-20 |
| EP1094712A1 (fr) | 2001-05-02 |
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