CA2345885A1 - Genes induits par des proteines morphogeniques osseuses et polypeptides associes, et leur utilisation dans des methodes diagnostiques et therapeutiques - Google Patents

Genes induits par des proteines morphogeniques osseuses et polypeptides associes, et leur utilisation dans des methodes diagnostiques et therapeutiques Download PDF

Info

Publication number
CA2345885A1
CA2345885A1 CA002345885A CA2345885A CA2345885A1 CA 2345885 A1 CA2345885 A1 CA 2345885A1 CA 002345885 A CA002345885 A CA 002345885A CA 2345885 A CA2345885 A CA 2345885A CA 2345885 A1 CA2345885 A1 CA 2345885A1
Authority
CA
Canada
Prior art keywords
induced
polypeptide
bmp
nucleic acid
bone morphogenic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002345885A
Other languages
English (en)
Inventor
Marie B. Demay
Ann Kearns
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
General Hospital Corp
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2345885A1 publication Critical patent/CA2345885A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

L'invention se rapporte à des gènes induits par des protéines morphogéniques osseuses (BMP), tels que CAP6, AAp2 et AAP32, aux polypeptides codés par ces gènes, ainsi qu'à des méthodes diagnostiques et thérapeutiques qui font usage de ces molécules.
CA002345885A 1998-10-15 1999-10-15 Genes induits par des proteines morphogeniques osseuses et polypeptides associes, et leur utilisation dans des methodes diagnostiques et therapeutiques Abandoned CA2345885A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10441698P 1998-10-15 1998-10-15
US60/104,416 1998-10-15
PCT/US1999/024263 WO2000021976A1 (fr) 1998-10-15 1999-10-15 Genes induits par des proteines morphogeniques osseuses et polypeptides associes, et leur utilisation dans des methodes diagnostiques et therapeutiques

Publications (1)

Publication Number Publication Date
CA2345885A1 true CA2345885A1 (fr) 2000-04-20

Family

ID=22300375

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002345885A Abandoned CA2345885A1 (fr) 1998-10-15 1999-10-15 Genes induits par des proteines morphogeniques osseuses et polypeptides associes, et leur utilisation dans des methodes diagnostiques et therapeutiques

Country Status (5)

Country Link
EP (1) EP1121374A1 (fr)
JP (1) JP2002527053A (fr)
AU (1) AU6519299A (fr)
CA (1) CA2345885A1 (fr)
WO (1) WO2000021976A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060058516A1 (en) * 2000-04-10 2006-03-16 Burkhard Scharm Novel serine-threonine kinase
WO2001082973A2 (fr) * 2000-04-28 2001-11-08 University Of Pittsburgh Of The Commonwealth System Of Higher Education Vecteurs viraux et non viraux en tant que vehicules d'administration de transgenes pour le traitement de pathologies osseuses
EP1419264A2 (fr) * 2001-04-06 2004-05-19 Incyte Genomics, Inc. Kinases et phosphatases
WO2003080825A2 (fr) * 2002-03-27 2003-10-02 Bayer Healthcare Ag Regulation de kinase humaine inductible par bmp-2

Also Published As

Publication number Publication date
JP2002527053A (ja) 2002-08-27
WO2000021976A1 (fr) 2000-04-20
AU6519299A (en) 2000-05-01
EP1121374A1 (fr) 2001-08-08

Similar Documents

Publication Publication Date Title
US6524799B1 (en) DNA encoding sparc-related proteins
US6610510B1 (en) Morphogenic proteins
JP2002538841A (ja) ２７個のヒト分泌タンパク質
JP2002532083A (ja) ４７個のヒト分泌タンパク質
US20090077681A1 (en) Methods for Diagnosing and Treating Heart Disease
WO1998007736A9 (fr) Gene don-1, polypeptides et utilisations de ceux-ci
EP1015474A1 (fr) Gene don-1, polypeptides et utilisations de ceux-ci
CA2394753A1 (fr) Polynucleotides et polypeptides de la protein thyrosine phosphatase humaine, et anticorps
AU726918B2 (en) TGFbeta signal transduction proteins, genes, and uses related thereto
JP2002539842A (ja) ４５個のヒト分泌タンパク質
CA2230138A1 (fr) Proteines du complexe cycline/cdk et leurs utilisations
CA2345885A1 (fr) Genes induits par des proteines morphogeniques osseuses et polypeptides associes, et leur utilisation dans des methodes diagnostiques et therapeutiques
JP2002543764A (ja) ４６個のヒト分泌タンパク質
AU2002242116A1 (en) Methods for diagnosing and treating heart disease
WO2003028536A2 (fr) Methodes permettant de diagnostiquer et de traiter les maladies cardiaques
AU2002337787A1 (en) Methods for diagnosing and treating heart disease
JP2004526435A (ja) 心疾患の診断および治療の方法
MXPA01003754A (en) Bone morphogenic protein-induced genes and polypeptides, and their use in diagnostic and therapeutic methods
US20020127594A1 (en) Don-1 gene and polypeptides and uses therefor
US6537554B1 (en) Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis
CA2335326A1 (fr) Sequences nucleotidiques et sequences d'acides amines de proteines secretees en rapport avec l'angiogenese
US20030104573A1 (en) Nucleotide sequences and amino acid sequences of secreted proteins involved in angiogenesis
JP2002539847A (ja) ４９個のヒト分泌タンパク質
JP2003520031A (ja) ２８個のヒト分泌タンパク質
JP2002543763A (ja) ４８個のヒト分泌タンパク質

Legal Events

Date Code Title Description
FZDE Dead