CA2347079A1 - Aminoacylase et son utilisation pour la preparation de d-acides amines - Google Patents

Aminoacylase et son utilisation pour la preparation de d-acides amines Download PDF

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Publication number
CA2347079A1
CA2347079A1 CA002347079A CA2347079A CA2347079A1 CA 2347079 A1 CA2347079 A1 CA 2347079A1 CA 002347079 A CA002347079 A CA 002347079A CA 2347079 A CA2347079 A CA 2347079A CA 2347079 A1 CA2347079 A1 CA 2347079A1
Authority
CA
Canada
Prior art keywords
ala
gly
leu
arg
val
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002347079A
Other languages
English (en)
Inventor
Stephen John Clifford Taylor
Robert Christopher Brown
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chirotech Technology Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9822947.9A external-priority patent/GB9822947D0/en
Priority claimed from GBGB9907739.8A external-priority patent/GB9907739D0/en
Application filed by Individual filed Critical Individual
Publication of CA2347079A1 publication Critical patent/CA2347079A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/04—Alpha- or beta- amino acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/006—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
    • C12P41/007—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures by reactions involving acyl derivatives of racemic amines

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

Enzyme isolé capable d'hydrolyser N-acétyl-D-tryptophane à une concentration de substrat de 10 g/l et exerçant une conversion plus rapide de (R)-N-acétyl-2-thiènylalanine que de (R)-N-acétyl-4-chlorophénylalanine. Cet enzyme est utile pour préparer des D-acides aminés.
CA002347079A 1998-10-20 1999-10-20 Aminoacylase et son utilisation pour la preparation de d-acides amines Abandoned CA2347079A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9822947.9 1998-10-20
GBGB9822947.9A GB9822947D0 (en) 1998-10-20 1998-10-20 Aminoacylase and its use in the production of d-aminoacids
GBGB9907739.8A GB9907739D0 (en) 1999-04-01 1999-04-01 Aminoacylase and its use in the production of D-aminoacids
GB9907739.8 1999-04-01
PCT/GB1999/003458 WO2000023598A1 (fr) 1998-10-20 1999-10-20 Aminoacylase et son utilisation pour la preparation de d-acides amines

Publications (1)

Publication Number Publication Date
CA2347079A1 true CA2347079A1 (fr) 2000-04-27

Family

ID=26314541

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002347079A Abandoned CA2347079A1 (fr) 1998-10-20 1999-10-20 Aminoacylase et son utilisation pour la preparation de d-acides amines

Country Status (6)

Country Link
EP (1) EP1121446A1 (fr)
JP (1) JP2002527110A (fr)
KR (1) KR20010075649A (fr)
AU (1) AU6222799A (fr)
CA (1) CA2347079A1 (fr)
WO (1) WO2000023598A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4526157B2 (ja) 2000-01-27 2010-08-18 ダイセル化学工業株式会社 Ｄ−アミノアシラーゼ、およびそれをコードする遺伝子
KR20020087948A (ko) * 2001-02-01 2002-11-23 미쯔이가가꾸가부시끼가이샤 신규 ｄ-아미노아실라제를 코딩하는 ｄｎａ 및 그것을사용한 ｄ-아미노산의 제조 방법
EP1435388B1 (fr) 2002-12-24 2012-12-12 Daicel Corporation Mutants de la D-aminoacylase d'Alcaligenes denitrificans pour une meilleure producion d'aminoacides-D
CN108624577B (zh) * 2017-03-22 2021-07-27 中国科学院天津工业生物技术研究所 用于催化n-乙酰-d-色氨酸水解生成d-色氨酸的新酶
KR20220096237A (ko) 2020-12-30 2022-07-07 이종학 수산물 유통 서비스 시스템

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5037277B2 (fr) * 1972-08-31 1975-12-01
JPS5233194B2 (fr) * 1973-04-24 1977-08-26
JPS62126976A (ja) * 1985-11-26 1987-06-09 Agency Of Ind Science & Technol Ｄ−アミノアシラ−ゼの製造法
JPH0783711B2 (ja) * 1987-06-29 1995-09-13 ダイセル化学工業株式会社 新規なｄ―アミノアシラーゼの製造法
US4981799A (en) * 1987-08-21 1991-01-01 Takeda Chemical Industries, Ltd. Acylamino acid racemase, production and use thereof
JP2869793B2 (ja) * 1989-03-07 1999-03-10 第一化学薬品株式会社 酸性ｄ―アミノ酸に作用するｄ―アミノアシラーゼ及びその製造法
US5206162A (en) * 1991-10-17 1993-04-27 National Science Council Of Republic Of China Process for making D-aminoacylase
JP4063400B2 (ja) * 1997-07-31 2008-03-19 ダイセル化学工業株式会社 Ｄ−アミノアシラーゼ

Also Published As

Publication number Publication date
JP2002527110A (ja) 2002-08-27
WO2000023598A1 (fr) 2000-04-27
KR20010075649A (ko) 2001-08-09
EP1121446A1 (fr) 2001-08-08
AU6222799A (en) 2000-05-08

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Date Code Title Description
FZDE Dead