CA2352520A1 - Synthese de derives de tetrahydrothieno-[3,2-c]-pyridine - Google Patents

Synthese de derives de tetrahydrothieno-[3,2-c]-pyridine Download PDF

Info

Publication number: CA2352520A1
Authority: CA; Canada
Prior art keywords: formula; compound; see; iii; hydrogen
Prior art date: 2001-07-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

CA 2352520

Other languages

English (en)

Other versions

CA2352520C (fr

Inventor

Stephen E. Horne

Jaipal Reddy Nagireddy

Laura Kaye Mcconachie

Gamini Weeratunga

Bogdan M. Comanita

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Apotex Pharmachem Inc

Original Assignee

Brantford Chemicals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-07-06

Filing date

2001-07-06

Publication date

2003-01-06

2001-07-06 Application filed by Brantford Chemicals Inc filed Critical Brantford Chemicals Inc

2001-07-06 Priority to CA 2352520 priority Critical patent/CA2352520C/fr

2001-07-11 Priority to US09/902,165 priority patent/US6495691B1/en

2002-07-05 Priority to PCT/CA2002/001017 priority patent/WO2003004502A1/fr

2002-07-05 Priority to EP02745008A priority patent/EP1404681A1/fr

2003-01-06 Publication of CA2352520A1 publication Critical patent/CA2352520A1/fr

2007-10-02 Application granted granted Critical

2007-10-02 Publication of CA2352520C publication Critical patent/CA2352520C/fr

2021-07-06 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

OJYDKYKQCVPTFG-UHFFFAOYSA-N 2,3,3a,4-tetrahydrothieno[3,2-c]pyridine Chemical class C1N=CC=C2SCCC21 OJYDKYKQCVPTFG-UHFFFAOYSA-N 0.000 title abstract 2
150000001875 compounds Chemical class 0.000 abstract 7
WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000000217 alkyl group Chemical group 0.000 abstract 2
150000002431 hydrogen Chemical group 0.000 abstract 2
KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical group NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical class [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
125000004423 acyloxy group Chemical group 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000005333 aroyloxy group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
125000004104 aryloxy group Chemical group 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
150000004649 carbonic acid derivatives Chemical group 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003638 chemical reducing agent Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
150000002825 nitriles Chemical group 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

CA 2352520 2001-07-06 2001-07-06 Synthese de derives de tetrahydrothieno-[3,2-c]-pyridine Expired - Fee Related CA2352520C (fr)

Priority Applications (4)

Application Number	Priority Date	Filing Date	Title
CA 2352520 CA2352520C (fr)	2001-07-06	2001-07-06	Synthese de derives de tetrahydrothieno-[3,2-c]-pyridine
US09/902,165 US6495691B1 (en)	2001-07-06	2001-07-11	Process for the preparation of tetrahydrothieno[3,2-c]pyridine derivatives
PCT/CA2002/001017 WO2003004502A1 (fr)	2001-07-06	2002-07-05	Procede de preparation de derives de tetrahydrothieno[3,2-c]pyridine
EP02745008A EP1404681A1 (fr)	2001-07-06	2002-07-05	Procede de preparation de derives de tetrahydrothieno 3,2-c]pyridine

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
CA 2352520 CA2352520C (fr)	2001-07-06	2001-07-06	Synthese de derives de tetrahydrothieno-[3,2-c]-pyridine

Publications (2)

Publication Number	Publication Date
CA2352520A1 true CA2352520A1 (fr)	2003-01-06
CA2352520C CA2352520C (fr)	2007-10-02

Family

ID=4169420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
CA 2352520 Expired - Fee Related CA2352520C (fr)	2001-07-06	2001-07-06	Synthese de derives de tetrahydrothieno-[3,2-c]-pyridine

Country Status (3)

Country	Link
EP (1)	EP1404681A1 (fr)
CA (1)	CA2352520C (fr)
WO (1)	WO2003004502A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100678287B1 (ko) *	2005-06-23	2007-02-02	한미약품 주식회사	클로피도그렐의 제조방법 및 이에 사용되는 중간체
US20070191609A1 (en) *	2006-02-13	2007-08-16	Lee Pharma Limited	Process for preparation of clopidogrel bisulphate form-1
PL380849A1 (pl) *	2006-10-17	2008-04-28	Adamed Spółka Z Ograniczoną Odpowiedzialnością	Krystaliczna postać racemicznego -(2-chlorofenylo)-6,7-dihydrotieno[3,2-c]pirydylo-5(4H)-octanu metylu, sposób jej wytwarzania i zastosowanie

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2424278A1 (fr) *	1978-04-24	1979-11-23	Parcor	Procede de preparation de thieno(2,3-c) et thieno(3,2-c)pyridines
FR2530247B1 (fr) *	1982-07-13	1986-05-16	Sanofi Sa	Nouveaux derives de la thieno (3, 2-c) pyridine, leur procede de preparation et leur application therapeutique

2001
- 2001-07-06 CA CA 2352520 patent/CA2352520C/fr not_active Expired - Fee Related
2002
- 2002-07-05 EP EP02745008A patent/EP1404681A1/fr not_active Withdrawn
- 2002-07-05 WO PCT/CA2002/001017 patent/WO2003004502A1/fr not_active Ceased

Also Published As

Publication number	Publication date
EP1404681A1 (fr)	2004-04-07
WO2003004502A1 (fr)	2003-01-16
CA2352520C (fr)	2007-10-02

Legal Events

Date	Code	Title	Description
2001-07-06	EEER	Examination request
2012-07-06	MKLA	Lapsed

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