CA2353802C - Nouvel antigene protecteur de streptococci du groupe a - Google Patents

Nouvel antigene protecteur de streptococci du groupe a Download PDF

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Publication number
CA2353802C
CA2353802C CA2353802A CA2353802A CA2353802C CA 2353802 C CA2353802 C CA 2353802C CA 2353802 A CA2353802 A CA 2353802A CA 2353802 A CA2353802 A CA 2353802A CA 2353802 C CA2353802 C CA 2353802C
Authority
CA
Canada
Prior art keywords
spa
polypeptide
isolated
nucleic acid
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2353802A
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English (en)
Other versions
CA2353802A1 (fr
Inventor
James Dale
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Tennessee Research Foundation
Original Assignee
University of Tennessee Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Tennessee Research Foundation filed Critical University of Tennessee Research Foundation
Publication of CA2353802A1 publication Critical patent/CA2353802A1/fr
Application granted granted Critical
Publication of CA2353802C publication Critical patent/CA2353802C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne la découverte d'un nouvel antigène protecteur de Streptococcus (désigné sous le nom de Spa) qui a été identifié et isolé des Streptococci. Le Spa est un antigène de surface distinct de la protéine M qui évoque des anticorps opsoniques qui servent de protection contre de multiples sérotypes de streptococci. L'invention concerne également des polypeptides, des protéines, des peptides Spa isolés, et des anticorps contre ces derniers, ainsi que des acides nucléiques codant les antigènes peptides et polypeptides Spa. L'invention concerne en outre des méthodes d'identification et d'isolement d'un polypeptide Spa, des compositions thérapeutiques comprenant des antigènes ou des anticorps Spa et des méthodes d'utilisation de ces derniers visant à protéger un animal contre une infection de Streptococcus.
CA2353802A 1998-12-22 1999-12-22 Nouvel antigene protecteur de streptococci du groupe a Expired - Fee Related CA2353802C (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US11379498P 1998-12-22 1998-12-22
US60/113,794 1998-12-22
US11473098P 1998-12-31 1998-12-31
US60/114,730 1998-12-31
PCT/US1999/030807 WO2000037648A1 (fr) 1998-12-22 1999-12-22 Antigene protecteur de streptococci de groupe a (spa)

Publications (2)

Publication Number Publication Date
CA2353802A1 CA2353802A1 (fr) 2000-06-29
CA2353802C true CA2353802C (fr) 2013-10-01

Family

ID=26811487

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2353802A Expired - Fee Related CA2353802C (fr) 1998-12-22 1999-12-22 Nouvel antigene protecteur de streptococci du groupe a

Country Status (5)

Country Link
EP (1) EP1141311A1 (fr)
JP (1) JP2002533084A (fr)
AU (1) AU762100B2 (fr)
CA (1) CA2353802C (fr)
WO (1) WO2000037648A1 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6716433B1 (en) 1997-09-12 2004-04-06 University Of Tennessee Research Foundation Group a streptococcal vaccines
AU2002365184A1 (en) * 2001-10-26 2003-07-30 Id Biomedical Corporation Of Washington Efficient protein expression system
US7255867B2 (en) 2002-11-15 2007-08-14 Id Biomedical Corporation Of Quebec Vaccine
CA2521862C (fr) * 2003-04-10 2012-10-16 President And Fellows Of Harvard College Formation et regulation d'especes fluidiques
CN1842368B (zh) 2003-08-27 2014-05-28 哈佛大学 流体物种的电子控制
EP2292647A3 (fr) * 2006-07-07 2011-06-08 Intercell AG Petits antigènes pyogènes streptococcus et leur utilisation
AU2009313615B2 (en) 2008-11-05 2012-11-29 Regents Of The University Of Minnesota Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (BHS) disease
AU2012271336B2 (en) 2011-06-17 2017-03-02 University Of Tennessee Research Foundation Group A streptococcus multivalent vaccine
EP2953641A4 (fr) 2013-02-11 2016-11-16 Univ Tennessee Res Foundation Protéines apparentées à m de streptocoque de groupe a et leurs procédés d'utilisation
CN118388609B (zh) * 2024-04-24 2025-03-25 青岛立见生物科技有限公司 一种低浓度酶标记链球菌蛋白g的稳定保护剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0618813B1 (fr) * 1992-09-16 2002-01-09 The University Of Tennessee Research Corporation Antigene de la proteine m hybride et porteur destine au vaccin anti-streptococcique du groupe a
DE69331733T2 (de) * 1992-09-16 2002-08-22 The University Of Tennessee Research Corp., Knoxville Rekombinantes vielwertiges m-protein-vakzin
IES960488A2 (en) * 1996-07-03 1997-11-19 Trinity College Dublin Subunit Vaccine for Streptococcus Equi

Also Published As

Publication number Publication date
JP2002533084A (ja) 2002-10-08
AU2384600A (en) 2000-07-12
AU762100B2 (en) 2003-06-19
WO2000037648A1 (fr) 2000-06-29
CA2353802A1 (fr) 2000-06-29
EP1141311A1 (fr) 2001-10-10

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MKLA Lapsed

Effective date: 20181224