CA2360690A1 - Fragments de region kringle 4 de plasminogene et procedes d'utilisation - Google Patents
Fragments de region kringle 4 de plasminogene et procedes d'utilisation Download PDFInfo
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- CA2360690A1 CA2360690A1 CA002360690A CA2360690A CA2360690A1 CA 2360690 A1 CA2360690 A1 CA 2360690A1 CA 002360690 A CA002360690 A CA 002360690A CA 2360690 A CA2360690 A CA 2360690A CA 2360690 A1 CA2360690 A1 CA 2360690A1
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- kringle
- region fragment
- region
- plasminogen
- angiostatin
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6435—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21007—Plasmin (3.4.21.7), i.e. fibrinolysin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des fragments d'un inhibiteur de prolifération de cellules endothéliales et un procédé d'utilisation associé. L'inhibiteur de prolifération de cellules endothéliales est une protéine dérivée du plasminogène, ou plus spécifiquement un fragment de région kringle 4 d'angiostatine. Les fragments de région kringle 4 correspondent généralement à des structures de kringle 4 présentes dans l'inhibiteur de prolifération de cellules endothéliales. L'activité inhibitrice de cellules endothéliales de ces fragments constitue un moyen permettant d'inhiber l'angiogenèse de tumeurs et de traiter des affections induites par l'angiogenèse.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11761799P | 1999-01-28 | 1999-01-28 | |
| US60/117,617 | 1999-01-28 | ||
| US37071999A | 1999-08-09 | 1999-08-09 | |
| US09/370,719 | 1999-08-09 | ||
| PCT/US2000/002091 WO2000044391A2 (fr) | 1999-01-28 | 2000-01-26 | Fragments de region kringle 4 de plasminogene et procedes d'utilisation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2360690A1 true CA2360690A1 (fr) | 2000-08-03 |
Family
ID=26815458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002360690A Abandoned CA2360690A1 (fr) | 1999-01-28 | 2000-01-26 | Fragments de region kringle 4 de plasminogene et procedes d'utilisation |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1147202A2 (fr) |
| JP (1) | JP2002535372A (fr) |
| AU (1) | AU2974300A (fr) |
| CA (1) | CA2360690A1 (fr) |
| WO (1) | WO2000044391A2 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2394167A1 (fr) * | 1999-12-15 | 2001-06-21 | Entremed, Inc. | Compositions et procedes d'inhibition de la proliferation de cellules endotheliales |
| US20020159992A1 (en) * | 2000-09-29 | 2002-10-31 | Jack Henkin | Antiangiogenic polypeptides and methods for inhibiting angiogenesis |
| TWI725092B (zh) | 2015-12-18 | 2021-04-21 | 大陸商深圳瑞健生命科學硏究院有限公司 | 纖溶酶原在製備預防或治療糖尿病腎病或其相關病症之藥劑上的用途 |
| CN106890324A (zh) * | 2015-12-18 | 2017-06-27 | 深圳瑞健生命科学研究院有限公司 | 一种预防和治疗糖尿病肾病的方法 |
| JP7175270B2 (ja) | 2016-12-15 | 2022-11-18 | タレンゲン インターナショナル リミテッド | グルカゴン、インスリンを正常なバランスに戻らせる方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUT76095A (en) * | 1994-04-26 | 1997-06-30 | Childrens Medical Center | Angiostatin and method of use for inhibition of angiogenesis |
| US5945403A (en) * | 1997-05-30 | 1999-08-31 | The Children's Medical Center Corporation | Angiostatin fragments and method of use |
| AU709633B2 (en) * | 1995-04-26 | 1999-09-02 | Children's Medical Center Corporation | Angiostatin fragments and aggregate angiostatin and methods of use |
-
2000
- 2000-01-26 CA CA002360690A patent/CA2360690A1/fr not_active Abandoned
- 2000-01-26 WO PCT/US2000/002091 patent/WO2000044391A2/fr not_active Ceased
- 2000-01-26 EP EP00908395A patent/EP1147202A2/fr not_active Withdrawn
- 2000-01-26 JP JP2000595693A patent/JP2002535372A/ja active Pending
- 2000-01-26 AU AU29743/00A patent/AU2974300A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP1147202A2 (fr) | 2001-10-24 |
| AU2974300A (en) | 2000-08-18 |
| WO2000044391A3 (fr) | 2000-12-21 |
| JP2002535372A (ja) | 2002-10-22 |
| WO2000044391A2 (fr) | 2000-08-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Dead |