CA2367108A1 - Methode utilisee pour inhiber une proteine chaperonne - Google Patents
Methode utilisee pour inhiber une proteine chaperonne Download PDFInfo
- Publication number
- CA2367108A1 CA2367108A1 CA002367108A CA2367108A CA2367108A1 CA 2367108 A1 CA2367108 A1 CA 2367108A1 CA 002367108 A CA002367108 A CA 002367108A CA 2367108 A CA2367108 A CA 2367108A CA 2367108 A1 CA2367108 A1 CA 2367108A1
- Authority
- CA
- Canada
- Prior art keywords
- protein
- client
- coumarin
- polypeptide
- chaperone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 108010006519 Molecular Chaperones Proteins 0.000 title claims abstract description 57
- 102000005431 Molecular Chaperones Human genes 0.000 title claims abstract description 55
- 238000000034 method Methods 0.000 title claims abstract description 46
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- 102000004169 proteins and genes Human genes 0.000 claims abstract description 75
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 75
- 229960000956 coumarin Drugs 0.000 claims abstract description 45
- 235000001671 coumarin Nutrition 0.000 claims abstract description 45
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- Plural Heterocyclic Compounds (AREA)
- Saccharide Compounds (AREA)
- Pyrane Compounds (AREA)
Abstract
La présente invention concerne une méthode utilisée pour empêcher une protéine chaperonne de se fixer à sa protéine client ou à son polypeptide client. La méthode implique de mettre en relation un coumarinique ou un dérivé de coumarinique avec une protéine chaperonne, de telle sorte que le coumarinique ou le dérivé de coumarinique se fixe sur la protéine chaperonne, empêchant ainsi la protéine chaperonne de se fixer sur sa protéine client ou son polypeptide client.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12413599P | 1999-03-12 | 1999-03-12 | |
| US60/124,135 | 1999-03-12 | ||
| PCT/US2000/006482 WO2000053169A2 (fr) | 1999-03-12 | 2000-03-10 | Methode utilisee pour inhiber une proteine chaperonne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2367108A1 true CA2367108A1 (fr) | 2000-09-14 |
Family
ID=22412989
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002367108A Abandoned CA2367108A1 (fr) | 1999-03-12 | 2000-03-10 | Methode utilisee pour inhiber une proteine chaperonne |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1161231A2 (fr) |
| JP (1) | JP2003523313A (fr) |
| AU (1) | AU776652B2 (fr) |
| CA (1) | CA2367108A1 (fr) |
| WO (1) | WO2000053169A2 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7858331B2 (en) | 2000-11-03 | 2010-12-28 | Dana Farber Cancer Institute, Inc. | Compositions and methods for the treatment of cancer |
| EP1387678A1 (fr) * | 2001-05-03 | 2004-02-11 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschaften E.V. | Composes inhibant hsp90 et stimulant hsp70 et hsp40, utiles pour prevenir ou traiter des maladies associees a l'agregation de proteines et a la formation d'amyloides |
| US7959915B2 (en) | 2003-03-12 | 2011-06-14 | Tufts University | Inhibitors of extracellular Hsp90 |
| EP1457499A1 (fr) * | 2003-03-12 | 2004-09-15 | Tufts University School Of Medicine | Inhibiteurs de protéine de choc thermique (HSP90) extracellulaire |
| ES2432747T3 (es) | 2003-06-27 | 2013-12-05 | Kyowa Hakko Kirin Co., Ltd. | Inhibidores de proteínas de la familia HSP90 |
| DE102004039280A1 (de) | 2004-08-13 | 2006-02-23 | Merck Patent Gmbh | 1,5-Diphenyl-pyrazole |
| DE102004049078A1 (de) | 2004-10-08 | 2006-04-13 | Merck Patent Gmbh | Phenylpyrazole |
| AU2005301957B2 (en) * | 2004-11-03 | 2012-02-23 | Department Of Health And Human Services | Novobiocin analogues as anticancer agents |
| US8212012B2 (en) | 2004-11-03 | 2012-07-03 | University Of Kansas | Novobiocin analogues having modified sugar moieties |
| DE102005009440A1 (de) | 2005-03-02 | 2006-09-07 | Merck Patent Gmbh | Thienopyridinderivate |
| DE102007002715A1 (de) | 2007-01-18 | 2008-07-24 | Merck Patent Gmbh | Triazolderivat |
| DE102007028521A1 (de) | 2007-06-21 | 2008-12-24 | Merck Patent Gmbh | Indazolamidderivate |
| DE102007032739A1 (de) | 2007-07-13 | 2009-01-15 | Merck Patent Gmbh | Chinazolinamidderivate |
| DE102007041116A1 (de) | 2007-08-30 | 2009-03-05 | Merck Patent Gmbh | 1,3-Dihydro-isoindolderivate |
| US8546320B2 (en) | 2008-11-14 | 2013-10-01 | Kyoto University | Hsp9O-targeted anti-cancer chimeric peptide |
| DE102008061214A1 (de) | 2008-12-09 | 2010-06-10 | Merck Patent Gmbh | Chinazolinamidderivate |
| CN101942017B (zh) | 2009-07-07 | 2013-08-14 | 清华大学 | 一种新的肿瘤标志物 |
| DE102009054302A1 (de) | 2009-11-23 | 2011-05-26 | Merck Patent Gmbh | Chinazolinderivate |
| DE102010046837A1 (de) | 2010-09-29 | 2012-03-29 | Merck Patent Gmbh | Phenylchinazolinderivate |
| US9056104B2 (en) | 2011-05-20 | 2015-06-16 | The University Of Kansas | Dynamic inhibitors of heat shock protein 90 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5216014A (en) * | 1991-09-10 | 1993-06-01 | Sphinx Pharmaceuticals Corporation | Furo-coumarinsulfonamides as protein kinase C inhibitors |
-
2000
- 2000-03-10 JP JP2000603658A patent/JP2003523313A/ja active Pending
- 2000-03-10 EP EP00916277A patent/EP1161231A2/fr not_active Withdrawn
- 2000-03-10 WO PCT/US2000/006482 patent/WO2000053169A2/fr not_active Ceased
- 2000-03-10 AU AU37406/00A patent/AU776652B2/en not_active Ceased
- 2000-03-10 CA CA002367108A patent/CA2367108A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000053169A2 (fr) | 2000-09-14 |
| AU3740600A (en) | 2000-09-28 |
| JP2003523313A (ja) | 2003-08-05 |
| WO2000053169A8 (fr) | 2001-01-11 |
| EP1161231A2 (fr) | 2001-12-12 |
| AU776652B2 (en) | 2004-09-16 |
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