CA2372526A1 - Methodes et compositions pour realiser une synthese regulee de polypeptides - Google Patents

Methodes et compositions pour realiser une synthese regulee de polypeptides Download PDF

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Publication number
CA2372526A1
CA2372526A1 CA002372526A CA2372526A CA2372526A1 CA 2372526 A1 CA2372526 A1 CA 2372526A1 CA 002372526 A CA002372526 A CA 002372526A CA 2372526 A CA2372526 A CA 2372526A CA 2372526 A1 CA2372526 A1 CA 2372526A1
Authority
CA
Canada
Prior art keywords
amino acid
nca
thf
group
block
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002372526A
Other languages
English (en)
Inventor
Michael D. Wyrsta
Timothy J. Deming
Miaoer Yu
Jungyeon Hwang
Scott A. Curtin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California San Diego UCSD
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2372526A1 publication Critical patent/CA2372526A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/084—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing nitrogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/06—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents
    • C07K1/08—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents
    • C07K1/088—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using protecting groups or activating agents using activating agents containing other elements, e.g. B, Si, As

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)

Abstract

L'invention concerne des méthodes et des compositions destinées à générer des polypeptides présentant des propriétés matérielles variées. Ces méthodes incluent un moyen de production de copolypeptides amphiphiles séquencés autoassemblés et des protocoles associés pour adjoindre des aminoacide-N-carboxyanhydrides (NCAs) à fonction oligo(éthylèneglyco) à des chaînes polyaminoacides. Des méthodes additionnelles incluent un moyen d'adjonction d'un groupe terminal à la terminaison carboxy de la chaîne polyaminoacide par réaction d'un amide d'acide aminé alloc-protégé avec un complexe aux ligands donneur de métal de transition, aux fins de former un métallacycle amido amidate pouvant être utilisé dans d'autres réactions de polymérisation. L'invention concerne en outre de nouvelles compositions qui s'utilisent dans la synthèse et la mise au point de peptides comprenant des métallacycles à cinq et six chaînons contenant amido et des copolypeptides séquencés.
CA002372526A 1999-05-10 2000-05-10 Methodes et compositions pour realiser une synthese regulee de polypeptides Abandoned CA2372526A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US13330499P 1999-05-10 1999-05-10
US13330599P 1999-05-10 1999-05-10
US60/133,305 1999-05-10
US60/133,304 1999-05-10
US18744800P 2000-03-07 2000-03-07
US60/187,448 2000-03-07
US19305400P 2000-03-29 2000-03-29
US60/193,054 2000-03-29
PCT/US2000/012770 WO2000068252A1 (fr) 1999-05-10 2000-05-10 Methodes et compositions pour realiser une synthese regulee de polypeptides

Publications (1)

Publication Number Publication Date
CA2372526A1 true CA2372526A1 (fr) 2000-11-16

Family

ID=27495021

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372526A Abandoned CA2372526A1 (fr) 1999-05-10 2000-05-10 Methodes et compositions pour realiser une synthese regulee de polypeptides

Country Status (4)

Country Link
EP (1) EP1189928A1 (fr)
AU (1) AU4835200A (fr)
CA (1) CA2372526A1 (fr)
WO (1) WO2000068252A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109837255A (zh) * 2018-12-24 2019-06-04 深圳市安帝宝科技有限公司 一种化学修饰酮胺氧化酶的方法

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041856B2 (en) 2001-10-23 2006-05-09 Sumitomo Chemical Company, Limited Coupling catalyst and process using the same
JP4311069B2 (ja) 2003-01-17 2009-08-12 住友化学株式会社 カップリング化合物の製造方法
DE602004000266T2 (de) 2003-02-19 2006-08-31 Sumitomo Chemical Co., Ltd. Methode zur Herstellung eines Kreuzkupplungsprodukts aus einem Alkylhalogenid und einer Organoborverbindung
FR3100248B1 (fr) * 2019-09-03 2022-01-07 Univ Bordeaux Procédé de préparation de polymères et copolymères contrôlés à base de peptides en solution aqueuse

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ250375A (en) * 1992-12-09 1995-07-26 Ortho Pharma Corp Peg hydrazone and peg oxime linkage forming reagents and protein derivatives
US5581476A (en) * 1993-01-28 1996-12-03 Amgen Inc. Computer-based methods and articles of manufacture for preparing G-CSF analogs
GB9317618D0 (en) * 1993-08-24 1993-10-06 Royal Free Hosp School Med Polymer modifications
FR2727117A1 (fr) * 1994-11-18 1996-05-24 Geffard Michel Utilisation de conjugues de la polylysine pour la preparation de medicaments utiles dans le traitement des maladies neurodegeneratives et des affections degeneratives a caractere autoimmun

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109837255A (zh) * 2018-12-24 2019-06-04 深圳市安帝宝科技有限公司 一种化学修饰酮胺氧化酶的方法
CN109837255B (zh) * 2018-12-24 2023-03-14 深圳市安帝宝科技有限公司 一种化学修饰酮胺氧化酶的方法

Also Published As

Publication number Publication date
AU4835200A (en) 2000-11-21
WO2000068252A1 (fr) 2000-11-16
EP1189928A1 (fr) 2002-03-27

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Legal Events

Date Code Title Description
FZDE Discontinued