CA2372881A1 - Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies - Google Patents

Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies Download PDF

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Publication number
CA2372881A1
CA2372881A1 CA002372881A CA2372881A CA2372881A1 CA 2372881 A1 CA2372881 A1 CA 2372881A1 CA 002372881 A CA002372881 A CA 002372881A CA 2372881 A CA2372881 A CA 2372881A CA 2372881 A1 CA2372881 A1 CA 2372881A1
Authority
CA
Canada
Prior art keywords
tet
protein
sequence
proteins
residues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002372881A
Other languages
English (en)
Inventor
Klaus Fiebig
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of CA2372881A1 publication Critical patent/CA2372881A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

L'invention concerne de nouvelles protéines p53 comportant des domaines de tétramérisation (tet-p53) modifiés et de nouveaux acides nucléiques. L'invention concerne en outre l'utilisation des protéines tet-p53 dans le traitement de troubles associés aux p53.
CA002372881A 1999-05-12 2000-05-12 Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies Abandoned CA2372881A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13378399P 1999-05-12 1999-05-12
US60/133,783 1999-05-12
PCT/US2000/013248 WO2000068384A2 (fr) 1999-05-12 2000-05-12 Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies

Publications (1)

Publication Number Publication Date
CA2372881A1 true CA2372881A1 (fr) 2000-11-16

Family

ID=22460283

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002372881A Abandoned CA2372881A1 (fr) 1999-05-12 2000-05-12 Nouveaux acides nucleiques et proteines ayant une activite p53 et comportant des domaines de tetramerisation modifies

Country Status (5)

Country Link
EP (1) EP1179062A2 (fr)
JP (1) JP2003520023A (fr)
AU (1) AU4849200A (fr)
CA (1) CA2372881A1 (fr)
WO (1) WO2000068384A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7256260B1 (en) 1999-07-30 2007-08-14 The United States Of America, As Represented By The Secretary, Dept. Of Health And Human Services, Nih Human p53 mutations and a genetic system in yeast for functional identification of human p53 mutations
CA2380631A1 (fr) * 1999-07-30 2001-02-08 The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services Mutations du gene p53 humain, et systeme genetique de levures utilise pour l'identification fonctionnelle des mutations du gene p53 humain
AU2002349204A1 (en) * 2001-11-26 2003-06-10 University Health Network Self-assembling p53 peptides as gene delivery vehicles

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0799243A4 (fr) * 1994-11-28 1998-08-19 Wistar Inst PROTEINES p53 A DOMAINES DE TETRAMERISATION MODIFIES
WO1998031703A1 (fr) * 1997-01-17 1998-07-23 The Wistar Institute Of Anatomy & Biology Procedes de modification d'une structure proteique tridimensionnelle et compositions produites par un tel procede
US6429298B1 (en) * 1998-10-13 2002-08-06 Board Of Regents, The University Of Texas System Assays for identifying functional alterations in the p53 tumor suppressor

Also Published As

Publication number Publication date
JP2003520023A (ja) 2003-07-02
WO2000068384A3 (fr) 2001-02-15
EP1179062A2 (fr) 2002-02-13
AU4849200A (en) 2000-11-21
WO2000068384A2 (fr) 2000-11-16

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Legal Events

Date Code Title Description
FZDE Discontinued