CA2375509A1 - Fabrication d'ilots de cellules pancreatiques - Google Patents

Fabrication d'ilots de cellules pancreatiques Download PDF

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Publication number
CA2375509A1
CA2375509A1 CA002375509A CA2375509A CA2375509A1 CA 2375509 A1 CA2375509 A1 CA 2375509A1 CA 002375509 A CA002375509 A CA 002375509A CA 2375509 A CA2375509 A CA 2375509A CA 2375509 A1 CA2375509 A1 CA 2375509A1
Authority
CA
Canada
Prior art keywords
cells
pancreatic
islet
insulin
population
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002375509A
Other languages
English (en)
Inventor
Susan Bonner-Weir
Monica Taneja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joslin Diabetes Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2375509A1 publication Critical patent/CA2375509A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des procédés favorisant la différenciation des cellules pancréatiques, des procédés d'obtention d'îlots de Langerhans à partir de cellules pancréatiques différentiées et des méthodes de traitement d'un sujet souffrant d'une insuffisance de la fonction des îlots de Langerhans par administration de cellules d'îlot de Langerhans obtenues par lesdits procédés.
CA002375509A 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques Abandoned CA2375509A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14063999P 1999-06-23 1999-06-23
US60/140,639 1999-06-23
PCT/US2000/017208 WO2000078929A1 (fr) 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques

Publications (1)

Publication Number Publication Date
CA2375509A1 true CA2375509A1 (fr) 2000-12-28

Family

ID=22492159

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002375509A Abandoned CA2375509A1 (fr) 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques

Country Status (4)

Country Link
EP (1) EP1185622A4 (fr)
AU (1) AU5632600A (fr)
CA (1) CA2375509A1 (fr)
WO (1) WO2000078929A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610535B1 (en) 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
CA2415108A1 (fr) * 2000-06-30 2002-01-10 Amcyte, Inc. Culture de cellules embryonnaires pancreatiques presentant un stade de developpement intermediaire specifie
FR2814752A1 (fr) 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
IL162131A0 (en) 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
CN1599793A (zh) 2001-12-07 2005-03-23 杰龙公司 人胚胎干细胞衍生的软骨细胞前体
US7101546B2 (en) 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
JP2005537803A (ja) 2002-09-06 2005-12-15 アムサイト インコーポレーティッド Ｃｄ５６陽性ヒト成体膵臓内分泌前駆細胞
EP1636350B1 (fr) * 2003-06-23 2007-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Procede pour differencier des cellules souches en cellules qui produisent une hormone pancreatique
DE10362002B4 (de) * 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
EP1689321B1 (fr) 2003-11-07 2017-01-04 The University of Connecticut Systemes de tissus artificiels et leurs utilisations
DE102004017476B4 (de) 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung
EP1747459A1 (fr) * 2004-05-21 2007-01-31 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systemes de test multicellulaires
EP1747264B1 (fr) 2004-05-21 2012-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systemes de culture tissulaire et organique multicellulaires
JP2008520235A (ja) * 2004-11-22 2008-06-19 ラモト アット テル アヴィヴ ユニヴァーシティ リミテッド インスリンを産生可能な拡大され、かつ再分化した成体島β細胞の集団およびその作製方法
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
US10865383B2 (en) 2011-07-12 2020-12-15 Lineage Cell Therapeutics, Inc. Methods and formulations for orthopedic cell therapy
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
CN113308433A (zh) * 2021-04-27 2021-08-27 立沃生物科技（深圳）有限公司 一种胰岛体外培养表面杂细胞处理方法
CN114196614A (zh) * 2021-12-14 2022-03-18 福建省医学科学研究院 pAdM3C感染大鼠胰腺导管细胞促进转分化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells
WO2000047720A2 (fr) * 1999-02-10 2000-08-17 Curis, Inc. Cellules progenitrices de pancreas et procedes et utilisations associees
FR2814752A1 (fr) * 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations

Also Published As

Publication number Publication date
WO2000078929A1 (fr) 2000-12-28
EP1185622A4 (fr) 2002-09-18
AU5632600A (en) 2001-01-09
EP1185622A1 (fr) 2002-03-13

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