CA2375509A1 - Fabrication d'ilots de cellules pancreatiques - Google Patents

Fabrication d'ilots de cellules pancreatiques Download PDF

Info

Publication number
CA2375509A1
CA2375509A1 CA002375509A CA2375509A CA2375509A1 CA 2375509 A1 CA2375509 A1 CA 2375509A1 CA 002375509 A CA002375509 A CA 002375509A CA 2375509 A CA2375509 A CA 2375509A CA 2375509 A1 CA2375509 A1 CA 2375509A1
Authority
CA
Canada
Prior art keywords
cells
pancreatic
islet
insulin
population
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002375509A
Other languages
English (en)
Inventor
Susan Bonner-Weir
Monica Taneja
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Joslin Diabetes Center Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2375509A1 publication Critical patent/CA2375509A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/22—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from pancreatic cells

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Cette invention concerne des procédés favorisant la différenciation des cellules pancréatiques, des procédés d'obtention d'îlots de Langerhans à partir de cellules pancréatiques différentiées et des méthodes de traitement d'un sujet souffrant d'une insuffisance de la fonction des îlots de Langerhans par administration de cellules d'îlot de Langerhans obtenues par lesdits procédés.
CA002375509A 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques Abandoned CA2375509A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14063999P 1999-06-23 1999-06-23
US60/140,639 1999-06-23
PCT/US2000/017208 WO2000078929A1 (fr) 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques

Publications (1)

Publication Number Publication Date
CA2375509A1 true CA2375509A1 (fr) 2000-12-28

Family

ID=22492159

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002375509A Abandoned CA2375509A1 (fr) 1999-06-23 2000-06-23 Fabrication d'ilots de cellules pancreatiques

Country Status (4)

Country Link
EP (1) EP1185622A4 (fr)
AU (1) AU5632600A (fr)
CA (1) CA2375509A1 (fr)
WO (1) WO2000078929A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6610535B1 (en) 2000-02-10 2003-08-26 Es Cell International Pte Ltd. Progenitor cells and methods and uses related thereto
AU2001273108A1 (en) * 2000-06-30 2002-01-14 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
FR2814752A1 (fr) * 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations
CN101240262A (zh) 2001-12-07 2008-08-13 杰龙公司 源自人胚胎干细胞的胰岛细胞
US20030109038A1 (en) 2001-12-07 2003-06-12 Thies R. Scott Chondrocyte precursors derived from human embryonic stem cells
US7101546B2 (en) 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
AU2003268534A1 (en) 2002-09-06 2004-03-29 Amcyte Inc. Cd56 positive human adult pancreatic endocrine progenitor cells
US20070037281A1 (en) * 2003-06-23 2007-02-15 Fraunhofer-Gesellschaft Zur Forderung Der Angewandten Forschung E.V. Method for differentiating stem cells in cells that produce a pancreatic hormone
DE10362002B4 (de) * 2003-06-23 2006-10-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Adulte pluripotente Stammzellen
US8916184B2 (en) 2003-11-07 2014-12-23 University Of Connecticut Artificial tissue systems and uses thereof
DE102004017476B4 (de) 2004-04-08 2009-03-26 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren zur Herstellung einer Epithelzellen enthaltenden Zellzusammensetzung
WO2005114178A1 (fr) * 2004-05-21 2005-12-01 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systemes de test multicellulaires
EP1747264B1 (fr) 2004-05-21 2012-09-12 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Systemes de culture tissulaire et organique multicellulaires
WO2006054305A2 (fr) 2004-11-22 2006-05-26 Ramot At Tel Aviv University Ltd. Populations de cellules beta adultes d'ilot de langerhans etendues et redifferenciees permettant de produire de l'insuline et procede d'obtention associe
WO2007149182A2 (fr) 2006-06-19 2007-12-27 Geron Corporation Différenciation et enrichissement de cellules de type cellules des îlots pancréatiques à partir de cellules souches pluripotentes humaines
WO2013010045A1 (fr) 2011-07-12 2013-01-17 Biotime Inc. Nouveaux procédés et formulations pour thérapie cellulaire orthopédique
US10130288B2 (en) 2013-03-14 2018-11-20 Cell and Molecular Tissue Engineering, LLC Coated sensors, and corresponding systems and methods
US10405961B2 (en) 2013-03-14 2019-09-10 Cell and Molecular Tissue Engineering, LLC Coated surgical mesh, and corresponding systems and methods
CN113308433A (zh) * 2021-04-27 2021-08-27 立沃生物科技（深圳）有限公司 一种胰岛体外培养表面杂细胞处理方法
CN114196614A (zh) * 2021-12-14 2022-03-18 福建省医学科学研究院 pAdM3C感染大鼠胰腺导管细胞促进转分化方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4439521A (en) * 1981-10-21 1984-03-27 Ontario Cancer Institute Method for producing self-reproducing mammalian pancreatic islet-like structures
US5587309A (en) * 1994-04-29 1996-12-24 The United States Of America As Represented By The Department Of Health And Human Services Method of stimulating proliferation and differentiation of human fetal pancreatic cells ex vivo
US5861313A (en) * 1995-06-07 1999-01-19 Ontogeny, Inc. Method of isolating bile duct progenitor cells
US5681587A (en) * 1995-10-06 1997-10-28 Desmos, Inc. Growth of adult pancreatic islet cells
CA2362593A1 (fr) * 1999-02-10 2000-08-17 Curis, Inc. Cellules progenitrices de pancreas et procedes et utilisations associees
FR2814752A1 (fr) * 2000-10-02 2002-04-05 Chru Lille Procede d'obtention in vitro de cellules insulino- secretrices de mammifere et leurs utilisations

Also Published As

Publication number Publication date
WO2000078929A1 (fr) 2000-12-28
EP1185622A4 (fr) 2002-09-18
AU5632600A (en) 2001-01-09
EP1185622A1 (fr) 2002-03-13

Similar Documents

Publication Publication Date Title
US6815203B1 (en) Methods of making pancreatic islet cells
EP1185622A1 (fr) Fabrication d'ilots de cellules pancreatiques
KR101089591B1 (ko) 인간 배아 줄기세포 유래의 섬세포
AU2001279245B2 (en) Pancreatic progenitor cells
AU780794B2 (en) Pancreatic progenitor cells, methods and uses related thereto
Petropavlovskaia et al. Identification and characterization of small cells in the adult pancreas: potential progenitor cells?
CZ2004696A3 (cs) Endokrinní pankreatická diferenciace buněk stromatu odvozených z adipózní tkáně a její použití
US20160251627A1 (en) Differentiation and Enrichment of Islet-like Cells From Human Pluripotent Stem Cells
JP5785287B2 (ja) 脂肪組織由来細胞の調製方法
KR20120003855A (ko) 상피 줄기 세포용 배양 배지 및 상기 줄기 세포를 포함하는 오르가노이드
JP2004531262A (ja) ヒト胚性幹細胞由来インスリン産生細胞
AU2001279245A1 (en) Pancreatic progenitor cells
JP2003523323A (ja) 膵臓幹細胞および移植におけるその使用
US20030223974A1 (en) Cellular trans-differentiation
CA2189052A1 (fr) Compositions et methodes de simulation de la proliferation et de la differenciation de cellules pancreatiques du foetus et de l'adulte humain ex vivo
US20030003088A1 (en) Human pancreatic pluripotential stem cell line
CN102803475B (zh) 通过胰脏衍生的非内分泌上皮细胞和血管内皮细胞的组织复合物培养胰岛样组织的方法
US7527971B2 (en) Adult stem cell lines
US20150342999A1 (en) Methods and compositions for treating diabetes with ips derived pancreatic beta-like cells
WO2005059095A2 (fr) Dilatation et differenciation de cellules des ilots pancreatiques
CA3070750A1 (fr) Cellules pancreatiques fonctionnelles de felinsprovenant de tissu adipeux
Lee et al. Reversal of diabetes in rats using GLP-1-expressing adult pancreatic duct-like precursor cells transformed from acinar to ductal cells
US20050074876A1 (en) Bipotential liver cell lines from wild-type mammalian liver tissue
WO2007075956A2 (fr) Procede de production et d’utilisation de cellules endocrines pancreatiques
Hazrati The role of transforming growth factor-beta (TGF-) in the transdifferentiation of islets of Langerhans to duct-like epithelial structures

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead