CA2376065A1 - Cristallisation et determination de structure du facteur p d'elongation du staphylococcus aureus - Google Patents
Cristallisation et determination de structure du facteur p d'elongation du staphylococcus aureus Download PDFInfo
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- CA2376065A1 CA2376065A1 CA002376065A CA2376065A CA2376065A1 CA 2376065 A1 CA2376065 A1 CA 2376065A1 CA 002376065 A CA002376065 A CA 002376065A CA 2376065 A CA2376065 A CA 2376065A CA 2376065 A1 CA2376065 A1 CA 2376065A1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
L'invention concerne le facteur P d'élongation du Staphylococcus aureus S. aureusEE-P qui a été cristallisé, et la structure cristalline à rayons X en trois dimensions a été ramenée à une résolution de 1.9 .ANG.. La structure à rayons X sert à réduire la structure d'autres molécules ou complexes moléculaires, et à concevoir des inhibiteurs de S. aureusEF-P.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14785199P | 1999-08-06 | 1999-08-06 | |
| US60/147,851 | 1999-08-06 | ||
| PCT/US2000/021528 WO2001010906A1 (fr) | 1999-08-06 | 2000-08-04 | Cristallisation et determination de structure du facteur p d'elongation du staphylococcus aureus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2376065A1 true CA2376065A1 (fr) | 2001-02-15 |
Family
ID=22523167
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002376065A Abandoned CA2376065A1 (fr) | 1999-08-06 | 2000-08-04 | Cristallisation et determination de structure du facteur p d'elongation du staphylococcus aureus |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP1200468A1 (fr) |
| JP (1) | JP2003510250A (fr) |
| AU (1) | AU6401200A (fr) |
| CA (1) | CA2376065A1 (fr) |
| WO (1) | WO2001010906A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7217517B2 (en) | 2001-07-23 | 2007-05-15 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, and methods for modulating apoptosis |
| US7968523B2 (en) | 2001-07-23 | 2011-06-28 | Senesco Technologies, Inc. | Method for inducing apoptosis using apoptosis-specific EIF5-A |
| US7381708B2 (en) | 2001-07-23 | 2008-06-03 | Sensco Technologies, Inc. | Suppression of eIF5A1 expression by the use of antisense oligonucleotides for the prevention of retinal cell death in the glaucomatous eye |
| US7166467B2 (en) * | 2001-07-23 | 2007-01-23 | Senesco Technologies, Inc. | Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis |
| CN100558410C (zh) * | 2002-05-07 | 2009-11-11 | 森尼斯科技术公司 | 调节凋亡的核酸,多肽,以及方法 |
| WO2004078940A2 (fr) | 2003-03-05 | 2004-09-16 | Senesco Technologies, Inc. | Utilisation d'oligonucleotides antisens de siarn pour supprimer l'expression de eif-5a1 |
| CA2717637A1 (fr) | 2008-03-07 | 2009-09-17 | Senesco Technologies, Inc. | Utilisation d'arnsi pour obtenir la regulation negative d'un gene endogene en combinaison avec l'utilisation d'un produit de construction sens pour obtenir l'expression d'un polynucleotide desire |
| US8445638B2 (en) | 2008-09-03 | 2013-05-21 | Senesco Technologies, Inc. | Use of a truncated eIF-5A1 polynucleotide to induce apoptosis in cancer cells |
| US10077180B2 (en) | 2016-06-02 | 2018-09-18 | Cornelius, Inc. | Beverage dispensing heads with lighting modules |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1147422A1 (fr) * | 1999-01-27 | 2001-10-24 | Pharmacia & Upjohn Company | Dosages de modulateurs de l'activite du facteur d'elongation p |
-
2000
- 2000-08-04 JP JP2001515713A patent/JP2003510250A/ja active Pending
- 2000-08-04 CA CA002376065A patent/CA2376065A1/fr not_active Abandoned
- 2000-08-04 AU AU64012/00A patent/AU6401200A/en not_active Abandoned
- 2000-08-04 EP EP00951000A patent/EP1200468A1/fr not_active Withdrawn
- 2000-08-04 WO PCT/US2000/021528 patent/WO2001010906A1/fr not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU6401200A (en) | 2001-03-05 |
| JP2003510250A (ja) | 2003-03-18 |
| WO2001010906A9 (fr) | 2002-04-11 |
| EP1200468A1 (fr) | 2002-05-02 |
| WO2001010906A1 (fr) | 2001-02-15 |
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