CA2376261A1 - Systeme de liberation dans les voies gastro-intestinales inferieures - Google Patents

Systeme de liberation dans les voies gastro-intestinales inferieures Download PDF

Info

Publication number
CA2376261A1
CA2376261A1 CA002376261A CA2376261A CA2376261A1 CA 2376261 A1 CA2376261 A1 CA 2376261A1 CA 002376261 A CA002376261 A CA 002376261A CA 2376261 A CA2376261 A CA 2376261A CA 2376261 A1 CA2376261 A1 CA 2376261A1
Authority
CA
Canada
Prior art keywords
gastrointestinal tract
lower gastrointestinal
composition
disintegration
polymer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002376261A
Other languages
English (en)
Inventor
Yumio Kudo
Hiroki Ueshima
Kazuya Sakai
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mochida Pharmaceutical Co Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2376261A1 publication Critical patent/CA2376261A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891—Coated capsules; Multilayered drug free capsule shells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7007—Drug-containing films, membranes or sheets

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

L'invention concerne un système selon lequel une substance absorbée par voie orale et à administrer dans les voies digestives inférieures est administrée de façon sélective dans les voies digestives inférieures. Plus particulièrement, l'invention concerne un système permettant d'administrer de façon sûre et rapide la substance voulue dans les voies digestives inférieures sans qu'elle ne soit affectée par le changement de pH dans les voies digestives du fait d'un changement de la flore bactérienne. Les compositions se désintégrant dans les voies digestives inférieures sont caractérisées en ce qu'elles contiennent un composé <A~, lequel présente une masse moléculaire de 1000 ou moins et une liaison bisulfure, et un polymère <B~, lequel présente une masse moléculaire dépassant 1000 et est digéré par les bactéries entériques et/ou subit un ramollissement, un gonflement ou une dissolution inhérent(e) à une diminution du pH. L'invention concerne également des produits moulés à l'aide de ces compositions ainsi que des préparations à l'aide de ces produits moulés.
CA002376261A 1999-06-09 2000-06-09 Systeme de liberation dans les voies gastro-intestinales inferieures Abandoned CA2376261A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP11/199409 1999-06-09
JP19940999 1999-06-09
PCT/JP2000/003770 WO2000074720A1 (fr) 1999-06-09 2000-06-09 Systeme de liberation dans les voies digestives inferieures

Publications (1)

Publication Number Publication Date
CA2376261A1 true CA2376261A1 (fr) 2000-12-14

Family

ID=16407330

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002376261A Abandoned CA2376261A1 (fr) 1999-06-09 2000-06-09 Systeme de liberation dans les voies gastro-intestinales inferieures

Country Status (7)

Country Link
US (2) US6972132B1 (fr)
EP (1) EP1184038B1 (fr)
AT (1) ATE314091T1 (fr)
AU (1) AU5108200A (fr)
CA (1) CA2376261A1 (fr)
DE (1) DE60025201T2 (fr)
WO (1) WO2000074720A1 (fr)

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8535713B2 (en) 2007-04-04 2013-09-17 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US8951570B2 (en) 2007-04-26 2015-02-10 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US9220681B2 (en) 2012-07-05 2015-12-29 Sigmoid Pharma Limited Formulations
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops
US9320746B2 (en) 2013-02-21 2016-04-26 Sigmoid Pharma Limited Method for treating intestinal fibrosis
US9821024B2 (en) 2010-11-25 2017-11-21 Sigmoid Pharma Limited Immunomodulatory compositions
US9878036B2 (en) 2009-08-12 2018-01-30 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
US10434138B2 (en) 2013-11-08 2019-10-08 Sublimity Therapeutics Limited Formulations
US10993987B2 (en) 2014-11-07 2021-05-04 Sublimity Therapeutics Limited Compositions comprising Cyclosporin

Families Citing this family (20)

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ITMI20020731A1 (it) * 2002-04-08 2003-10-08 Ibsa Inst Biochimique Sa Composizioni farmaceutiche per acido acetilsalicilico e oli omega-3
WO2003090726A2 (fr) * 2002-04-25 2003-11-06 Banner Pharmacaps, Inc. Gelule molle a macher
ES2665464T3 (es) * 2003-03-28 2018-04-25 Sigmoid Pharma Limited Forma de dosificación oral sólida que contiene microcápsulas sin costuras
EP1727525A4 (fr) * 2004-03-23 2009-12-09 Lytone Enterprise Inc Capsule contenant du chitosane noye ou encapsule
RU2284832C2 (ru) * 2004-08-30 2006-10-10 Николай Александрович Киселев Антимикробная композиция для перорального введения
EP1802287A2 (fr) * 2004-09-27 2007-07-04 Sigmoid Biotechnologies Limited Formulations comprenant des minicapsules
JP5386176B2 (ja) * 2006-12-21 2014-01-15 フロイント産業株式会社 キトサン溶液及び該溶液から形成されたキトサンコーティング製剤
WO2010088645A2 (fr) * 2009-02-02 2010-08-05 Ecoblend, Llc Compositions pesticides et procédés d'utilisation associés
WO2010142456A1 (fr) * 2009-06-11 2010-12-16 Photocure Asa Compositions solides comprenant de l'acide 5-aminolévulinique
WO2011111783A1 (fr) * 2010-03-12 2011-09-15 カルピス株式会社 Agent de régulation de l'augmentation et de la diminution de lactobacillus bifidus dans le côlon
US8911780B2 (en) 2011-02-11 2014-12-16 Zx Pharma, Llc Multiparticulate L-menthol formulations and related methods
US8808736B2 (en) 2011-02-11 2014-08-19 Zx Pharma, Llc Enteric coated multiparticulate controlled release peppermint oil composition and related methods
WO2012109216A1 (fr) 2011-02-11 2012-08-16 Zx Pharma, Llc Formulations de l-menthol multiparticulaires et procédés associés
JP5102401B1 (ja) * 2012-03-30 2012-12-19 森下仁丹株式会社 大腸特異崩壊性カプセル
JP5957280B2 (ja) * 2012-05-02 2016-07-27 日清ファルマ株式会社 大腸デリバリーシームレスカプセル製剤及びその製造方法
JP5997034B2 (ja) * 2012-12-21 2016-09-21 日清ファルマ株式会社 キトサン含有組成物及びキトサンコーティング組成物
CA2909591C (fr) 2013-04-23 2017-03-28 Zx Pharma, Llc Composition enterique multiparticulaire revetue a sous-revetement proteique
CN113647993B (zh) * 2021-08-20 2023-06-16 成都医学院 一种无创肠道成分采集胶囊及其使用方法
EP4420656A4 (fr) * 2021-10-20 2025-10-15 Sunsho Pharmaceutical Co Ltd Composition pharmaceutique, et procédé de fabrication de celle-ci
WO2023119624A1 (fr) * 2021-12-24 2023-06-29 株式会社カマタ Capsule sans soudure

Family Cites Families (19)

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US4522625A (en) * 1982-09-29 1985-06-11 Alza Corporation Drug dispenser comprising wall formed of semipermeable member and enteric member
GB8518301D0 (en) 1985-07-19 1985-08-29 Fujisawa Pharmaceutical Co Hydrodynamically explosive systems
US5057317A (en) * 1987-03-24 1991-10-15 Chugai Seiyaku Kabushiki Kaisha Slow-release pharmaceutical agent
US5342624A (en) 1989-02-16 1994-08-30 British Technology Group Ltd. Dispensing device
BE1003677A3 (nl) 1990-01-29 1992-05-19 Schacht Etienne Werkwijze voor het bereiden van azobevattende polymeren en het gebruik ervan als geneesmiddelafgiftesystemen.
DE69131688T2 (de) 1990-05-04 2000-05-25 Perio Products Ltd., Hahotzvim System zur arzneistoffabgabe im colon
JPH064531B2 (ja) * 1990-06-04 1994-01-19 アイセロ化学株式会社 大腸崩壊性硬質カプセル
JP2773959B2 (ja) 1990-07-10 1998-07-09 信越化学工業株式会社 大腸内放出性固形製剤
JP3181062B2 (ja) 1991-01-31 2001-07-03 帝國製薬株式会社 下部消化管崩壊経口製剤
EP0617613B1 (fr) * 1991-12-20 1996-05-29 Pfizer Inc. Elements d'administration de medicament profiles et poreux, et procedes de production
ES2188657T3 (es) 1994-04-22 2003-07-01 Yamanouchi Pharma Co Ltd Sistema para la liberacion especifica en el colon de un farmaco.
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
AU690573B2 (en) * 1994-10-05 1998-04-30 West Pharmaceutical Services Drug Delivery & Clinical Research Centre Limited Process for the preparation of colon specific reduction sensitive polymers
US6004583A (en) * 1995-03-22 1999-12-21 Orex Pharmaceutical Development Corp. Protein-containing polymer composition for oral administration
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
WO1998005310A1 (fr) 1996-08-02 1998-02-12 Hisamitsu Pharmaceutical Co., Inc. Gelules destinees a des preparations orales et preparations de gelules destinees a une administration orale
JPH10324642A (ja) 1997-03-26 1998-12-08 Meiji Seika Kaisha Ltd 大腸送達性構造体
US6248362B1 (en) 1997-03-26 2001-06-19 Meiji Seika Kaisha, Ltd. Large intestinal delivery composite
KR20000011247A (ko) 1998-07-23 2000-02-25 김윤 다당류를이용한대장선택성약물전달조성물및약학제제

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9844513B2 (en) 2007-04-04 2017-12-19 Sigmoid Pharma Limited Oral pharmaceutical composition
US8911777B2 (en) 2007-04-04 2014-12-16 Sigmoid Pharma Limited Pharmaceutical composition of tacrolimus
US9114071B2 (en) 2007-04-04 2015-08-25 Sigmoid Pharma Limited Oral pharmaceutical composition
US10434140B2 (en) 2007-04-04 2019-10-08 Sublimity Therapeutics Limited Pharmaceutical cyclosporin compositions
US8535713B2 (en) 2007-04-04 2013-09-17 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US10434139B2 (en) 2007-04-04 2019-10-08 Sublimity Therapeutics Limited Oral pharmaceutical composition
US9387179B2 (en) 2007-04-04 2016-07-12 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US9585844B2 (en) 2007-04-04 2017-03-07 Sigmoid Pharma Limited Oral pharmaceutical composition
US9675558B2 (en) 2007-04-04 2017-06-13 Sigmoid Pharma Limited Pharmaceutical cyclosporin compositions
US8951570B2 (en) 2007-04-26 2015-02-10 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US9402788B2 (en) 2007-04-26 2016-08-02 Sigmoid Pharma Limited Manufacture of multiple minicapsules
US9278070B2 (en) 2009-05-18 2016-03-08 Sigmoid Pharma Limited Composition comprising oil drops
US9999651B2 (en) 2009-05-18 2018-06-19 Sigmoid Pharma Limited Composition comprising oil drops
US9878036B2 (en) 2009-08-12 2018-01-30 Sigmoid Pharma Limited Immunomodulatory compositions comprising a polymer matrix and an oil phase
US9821024B2 (en) 2010-11-25 2017-11-21 Sigmoid Pharma Limited Immunomodulatory compositions
US9950051B2 (en) 2012-07-05 2018-04-24 Sigmoid Pharma Limited Formulations
US9220681B2 (en) 2012-07-05 2015-12-29 Sigmoid Pharma Limited Formulations
US9980902B2 (en) 2013-02-21 2018-05-29 Sigmoid Pharma Limited Method for treating intestinal fibrosis
US9320746B2 (en) 2013-02-21 2016-04-26 Sigmoid Pharma Limited Method for treating intestinal fibrosis
US10434138B2 (en) 2013-11-08 2019-10-08 Sublimity Therapeutics Limited Formulations
US10993987B2 (en) 2014-11-07 2021-05-04 Sublimity Therapeutics Limited Compositions comprising Cyclosporin

Also Published As

Publication number Publication date
ATE314091T1 (de) 2006-01-15
US20050249800A1 (en) 2005-11-10
WO2000074720A1 (fr) 2000-12-14
EP1184038A1 (fr) 2002-03-06
DE60025201D1 (de) 2006-02-02
EP1184038A4 (fr) 2005-01-19
DE60025201T2 (de) 2006-06-29
US6972132B1 (en) 2005-12-06
AU5108200A (en) 2000-12-28
EP1184038B1 (fr) 2005-12-28

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued