CA2376474A1 - Peptides retro inverses derives du facteur d'inhbition de la leucemie - Google Patents
Peptides retro inverses derives du facteur d'inhbition de la leucemie Download PDFInfo
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- CA2376474A1 CA2376474A1 CA002376474A CA2376474A CA2376474A1 CA 2376474 A1 CA2376474 A1 CA 2376474A1 CA 002376474 A CA002376474 A CA 002376474A CA 2376474 A CA2376474 A CA 2376474A CA 2376474 A1 CA2376474 A1 CA 2376474A1
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- 230000000877 morphologic effect Effects 0.000 description 1
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- 210000004126 nerve fiber Anatomy 0.000 description 1
- 210000001178 neural stem cell Anatomy 0.000 description 1
- 230000004031 neuronal differentiation Effects 0.000 description 1
- 230000007823 neuropathy Effects 0.000 description 1
- 201000001119 neuropathy Diseases 0.000 description 1
- 230000016087 ovulation Effects 0.000 description 1
- 230000000624 ovulatory effect Effects 0.000 description 1
- 239000000813 peptide hormone Substances 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 208000033808 peripheral neuropathy Diseases 0.000 description 1
- 201000005936 periventricular leukomalacia Diseases 0.000 description 1
- 229920000747 poly(lactic acid) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 230000002028 premature Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 206010036807 progressive multifocal leukoencephalopathy Diseases 0.000 description 1
- 230000002685 pulmonary effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000026267 regulation of growth Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 230000002207 retinal effect Effects 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 210000004116 schwann cell Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000007790 solid phase Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 210000003594 spinal ganglia Anatomy 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
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- 238000006467 substitution reaction Methods 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
- 230000002889 sympathetic effect Effects 0.000 description 1
- 210000002437 synoviocyte Anatomy 0.000 description 1
- 238000007910 systemic administration Methods 0.000 description 1
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- 230000002588 toxic effect Effects 0.000 description 1
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- 230000008733 trauma Effects 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5415—Leukaemia inhibitory factor [LIF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
L'invention concerne les peptides rétro inverses dérivés du facteur d'inhibition de la leucémie (LIF) possédant entre 18 et environ 40 acides aminés et comprenant la séquence représentée dans SEQ ID NO : 1. Ces peptides ont la même activité que le LIF natif ainsi qu'une activité neurotrophique. Du fait de la liaison des acides aminés D dans les peptides, ces peptides sont moins sensibles à la dégradation protéolytique <i>in vivo</i>.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13968599P | 1999-06-16 | 1999-06-16 | |
| US60/139,685 | 1999-06-16 | ||
| PCT/US2000/016760 WO2000077029A1 (fr) | 1999-06-16 | 2000-06-16 | Peptides retro inverses derives du facteur d'inhbition de la leucemie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2376474A1 true CA2376474A1 (fr) | 2000-12-21 |
Family
ID=22487838
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002376474A Abandoned CA2376474A1 (fr) | 1999-06-16 | 2000-06-16 | Peptides retro inverses derives du facteur d'inhbition de la leucemie |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1183266A4 (fr) |
| JP (2) | JP2003502341A (fr) |
| AU (1) | AU5622700A (fr) |
| CA (1) | CA2376474A1 (fr) |
| IL (2) | IL147095A0 (fr) |
| WO (1) | WO2000077029A1 (fr) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5571787A (en) | 1993-07-30 | 1996-11-05 | Myelos Corporation | Prosaposin as a neurotrophic factor |
| WO2001064239A1 (fr) * | 2000-03-03 | 2001-09-07 | The Walter And Eliza Hall Institute Of Medical Research | Methode de traitement |
| AU2001237132B2 (en) * | 2000-03-03 | 2006-04-27 | Amrad Corporation Limited | A method of treatment |
| CA2645245A1 (fr) * | 2006-03-31 | 2007-10-11 | Queen's University At Kingston | Compositions et procedes de traitement de l'atherosclerose |
| CN107995913B (zh) | 2015-05-18 | 2022-02-11 | T细胞受体治疗公司 | 使用融合蛋白对tcr重编程的组合物和方法 |
| US11851491B2 (en) | 2016-11-22 | 2023-12-26 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5843892A (en) * | 1989-12-18 | 1998-12-01 | California Institute Of Technology | Stimulation of nerve growth and/or vitality |
| US5700909A (en) * | 1993-07-30 | 1997-12-23 | The Regents Of The University Of California | Prosaposin and cytokine-derived peptides |
| US6271196B1 (en) * | 1996-03-05 | 2001-08-07 | Regents Of The University Of Ca | Methods of alleviating neuropathic pain using prosaposin-derived peptides |
| WO1998039357A1 (fr) * | 1997-03-05 | 1998-09-11 | The Regents Of The University Of California | Procedes pour soulager les douleurs neuropathiques |
| US6458357B1 (en) * | 1997-09-09 | 2002-10-01 | Myelos Corporation | Retro-inverso neurotrophic and analgesic peptides |
-
2000
- 2000-06-16 EP EP00941527A patent/EP1183266A4/fr not_active Withdrawn
- 2000-06-16 CA CA002376474A patent/CA2376474A1/fr not_active Abandoned
- 2000-06-16 WO PCT/US2000/016760 patent/WO2000077029A1/fr not_active Ceased
- 2000-06-16 IL IL14709500A patent/IL147095A0/xx unknown
- 2000-06-16 AU AU56227/00A patent/AU5622700A/en not_active Abandoned
- 2000-06-16 JP JP2001503886A patent/JP2003502341A/ja not_active Withdrawn
-
2001
- 2001-12-13 IL IL147095A patent/IL147095A/en not_active IP Right Cessation
-
2011
- 2011-02-18 JP JP2011033594A patent/JP2011144184A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP1183266A4 (fr) | 2002-10-23 |
| AU5622700A (en) | 2001-01-02 |
| JP2003502341A (ja) | 2003-01-21 |
| EP1183266A1 (fr) | 2002-03-06 |
| WO2000077029A1 (fr) | 2000-12-21 |
| IL147095A0 (en) | 2002-08-14 |
| JP2011144184A (ja) | 2011-07-28 |
| IL147095A (en) | 2010-12-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |