CA2376607C - Systeme support metabolique exsanguine d'un organe ou tissu - Google Patents
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- CA2376607C CA2376607C CA2376607A CA2376607A CA2376607C CA 2376607 C CA2376607 C CA 2376607C CA 2376607 A CA2376607 A CA 2376607A CA 2376607 A CA2376607 A CA 2376607A CA 2376607 C CA2376607 C CA 2376607C
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- PGAVKCOVUIYSFO-UHFFFAOYSA-N uridine-triphosphate Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 PGAVKCOVUIYSFO-UHFFFAOYSA-N 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 229960001722 verapamil Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- 235000001892 vitamin D2 Nutrition 0.000 description 1
- 239000011653 vitamin D2 Substances 0.000 description 1
- 235000012711 vitamin K3 Nutrition 0.000 description 1
- 239000011652 vitamin K3 Substances 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 229940041603 vitamin k 3 Drugs 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 229940075420 xanthine Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
- A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
- A01N1/142—Apparatus
- A01N1/143—Apparatus for organ perfusion
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/10—Preservation of living parts
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
L'invention concerne un système support métabolique exsanguiné permettant de maintenir presque normal le rythme métabolique d'un organe ou tissu. Le système utilise une solution de perfusion chaude capable de supporter le métabolisme d'un organe ou tissu, ce qui lui conserve son intégrité fonctionnelle. Le système surveille également les paramètres de la solution de perfusion circulante, par exemple pH, température, osmolarité, débit, pression vasculaire et pression partielle de gaz respiratoires, et les régule afin que l'organe se maintienne dans des conditions presque physiologiques. L'invention traite également de l'utilisation du système aux fins d'une conservation de longue durée d'organes pour greffe, réanimation et reconstitution d'organes ayant subi des lésions ischémiques chaudes, comme système d'administration pharmaceutique et pronostiqueur de fonction de post-greffe d'organe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA2847723A CA2847723A1 (fr) | 1999-04-14 | 2000-04-13 | Systeme support metabolique exsanguine d'un organe ou tissu |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12925799P | 1999-04-14 | 1999-04-14 | |
| US60/129,257 | 1999-04-14 | ||
| PCT/US2000/009894 WO2000061166A1 (fr) | 1999-04-14 | 2000-04-13 | Systeme support metabolique exsanguine d'un organe ou tissu |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2847723A Division CA2847723A1 (fr) | 1999-04-14 | 2000-04-13 | Systeme support metabolique exsanguine d'un organe ou tissu |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2376607A1 CA2376607A1 (fr) | 2000-10-19 |
| CA2376607C true CA2376607C (fr) | 2014-06-10 |
Family
ID=22439141
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2847723A Abandoned CA2847723A1 (fr) | 1999-04-14 | 2000-04-13 | Systeme support metabolique exsanguine d'un organe ou tissu |
| CA2376607A Expired - Fee Related CA2376607C (fr) | 1999-04-14 | 2000-04-13 | Systeme support metabolique exsanguine d'un organe ou tissu |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2847723A Abandoned CA2847723A1 (fr) | 1999-04-14 | 2000-04-13 | Systeme support metabolique exsanguine d'un organe ou tissu |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1181032A4 (fr) |
| AU (1) | AU4345400A (fr) |
| CA (2) | CA2847723A1 (fr) |
| WO (1) | WO2000061166A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040038192A1 (en) * | 1999-04-14 | 2004-02-26 | Breonics, Inc. | System for exsanguinous metabolic support of an organ or tissue |
| US6582953B2 (en) | 1999-04-14 | 2003-06-24 | Breonics, Inc. | Organ chamber for exsanguinous metabolic support system |
| IL157392A0 (en) * | 2001-02-14 | 2004-02-19 | Robert J Hariri | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| JP2005522521A (ja) | 2002-04-15 | 2005-07-28 | ベス イスラエル デアコネス メディカル センター | ヘムオキシゲナーゼ−１およびヘム分解産物の使用法 |
| US8734867B2 (en) | 2007-12-28 | 2014-05-27 | Liveleaf, Inc. | Antibacterial having an extract of pomegranate combined with hydrogen peroxide |
| US9192635B2 (en) | 2011-06-24 | 2015-11-24 | Liveleaf, Inc. | Method of treating damaged mucosal or gastrointestinal tissue by administering a composition comprising a mixture of pomegranate and green tea extracts and releasably bound hydrogen peroxide |
| US8716351B1 (en) | 2012-12-23 | 2014-05-06 | Liveleaf, Inc. | Methods of treating gastrointestinal spasms |
| US10327442B2 (en) * | 2014-03-26 | 2019-06-25 | Tevosol, Inc. | Apparatus for maintenance of harvested hearts for transplanting |
| US10091986B2 (en) | 2016-05-09 | 2018-10-09 | Xor-Labs Toronto Inc. | Organ perfusion device and method |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0376763A3 (fr) * | 1988-10-26 | 1992-04-01 | McKelvey, Karen | Dispositif de transport d'organes humains destinés à la transplantation |
| US5484789A (en) * | 1989-10-31 | 1996-01-16 | The University Of North Carolina At Chapel Hill | Calcium channel blockers to improve preservation of organs stored for transplantation |
| US5747469A (en) * | 1991-03-06 | 1998-05-05 | Board Of Regents, The University Of Texas System | Methods and compositions comprising DNA damaging agents and p53 |
| US5217860A (en) * | 1991-07-08 | 1993-06-08 | The American National Red Cross | Method for preserving organs for transplantation by vitrification |
| US5338662A (en) * | 1992-09-21 | 1994-08-16 | Bio-Preserve Medical Corporation | Organ perfusion device |
| US5599659A (en) * | 1993-03-11 | 1997-02-04 | Breonics, Inc. | Preservation solution for ex vivo, warm preservation of tissues, explants,organs and vascular endothelial cells comprising retinal-derived fibroblast growth factor, cyclodextrin and chondroitin sulfate |
| WO1994021116A1 (fr) * | 1993-03-16 | 1994-09-29 | Alliance Pharmaceutical Corp. | Procede et solution de conservation d'organes chauds |
| ATE423464T1 (de) * | 1994-05-20 | 2009-03-15 | Breonics Inc | Verfahren zur überwachung der lebensfähigkeit transplantabler organe |
| WO1995031944A1 (fr) * | 1994-05-20 | 1995-11-30 | Vec Tec, Inc. | Procedes rendant les greffons non thrombogenes et sensiblement non immunogenes |
| US5843024A (en) * | 1996-05-17 | 1998-12-01 | Breonics, Inc. | Solution and process for resuscitation and preparation of ischemically damaged tissue |
-
2000
- 2000-04-13 CA CA2847723A patent/CA2847723A1/fr not_active Abandoned
- 2000-04-13 AU AU43454/00A patent/AU4345400A/en not_active Abandoned
- 2000-04-13 EP EP00923303A patent/EP1181032A4/fr not_active Withdrawn
- 2000-04-13 WO PCT/US2000/009894 patent/WO2000061166A1/fr not_active Ceased
- 2000-04-13 CA CA2376607A patent/CA2376607C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP1181032A1 (fr) | 2002-02-27 |
| WO2000061166A9 (fr) | 2002-01-31 |
| EP1181032A4 (fr) | 2004-08-25 |
| AU4345400A (en) | 2000-11-14 |
| CA2847723A1 (fr) | 2000-10-19 |
| CA2376607A1 (fr) | 2000-10-19 |
| WO2000061166A1 (fr) | 2000-10-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20190415 |