CA2382293A1 - Solutions de chlorite chimiquement stables, destinees au traitement du cancer et d'autres maladies - Google Patents
Solutions de chlorite chimiquement stables, destinees au traitement du cancer et d'autres maladies Download PDFInfo
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- CA2382293A1 CA2382293A1 CA002382293A CA2382293A CA2382293A1 CA 2382293 A1 CA2382293 A1 CA 2382293A1 CA 002382293 A CA002382293 A CA 002382293A CA 2382293 A CA2382293 A CA 2382293A CA 2382293 A1 CA2382293 A1 CA 2382293A1
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- cancer
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- stabilized chlorite
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- 229940053128 nerve growth factor Drugs 0.000 description 1
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- 238000010837 poor prognosis Methods 0.000 description 1
- OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
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- 230000036303 septic shock Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
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- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
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- 201000000596 systemic lupus erythematosus Diseases 0.000 description 1
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- 231100000765 toxin Toxicity 0.000 description 1
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- 230000005760 tumorsuppression Effects 0.000 description 1
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- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/20—Elemental chlorine; Inorganic compounds releasing chlorine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/40—Peroxides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Inorganic Chemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
L'invention concerne des méthodes d'utilisation d'une matrice de chlorite stabilisé, destinée à moduler des réponses immunes et à traiter le cancer. Cette matrice de chlorite stabilisé, lorsqu'on l'administre à un mammifère nécessitant un tel traitement, peut activer des cellules immunes de manière similaire à l'interféron gamma, mais elle ne produit pas de cytokines inflammatoires ou associées au stress, comme le facteur de nécrose tumorale alpha. Cette matrice de chlorite stabilisé régule également en amont l'expression de la protéine DCC dans des macrophages, protéine dont l'expression est associée à la transformation néoplasique. En activant les macrophages, la matrice de chlorite stabilisé est donc utile en tant qu'agent immunomodulateur et dans le traitement du cancer.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14942999P | 1999-08-18 | 1999-08-18 | |
| US60/149,429 | 1999-08-18 | ||
| PCT/US2000/022610 WO2001012205A2 (fr) | 1999-08-18 | 2000-08-18 | Solutions de chlorite chimiquement stables, destinees au traitement du cancer et d'autres maladies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2382293A1 true CA2382293A1 (fr) | 2001-02-22 |
Family
ID=22530238
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002382293A Abandoned CA2382293A1 (fr) | 1999-08-18 | 2000-08-18 | Solutions de chlorite chimiquement stables, destinees au traitement du cancer et d'autres maladies |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1408994A2 (fr) |
| KR (1) | KR20020038728A (fr) |
| CN (1) | CN1378456A (fr) |
| AU (1) | AU6913200A (fr) |
| CA (1) | CA2382293A1 (fr) |
| IL (1) | IL148189A0 (fr) |
| MX (1) | MXPA02001724A (fr) |
| NO (1) | NO20020751L (fr) |
| NZ (1) | NZ517673A (fr) |
| PL (1) | PL353769A1 (fr) |
| RU (1) | RU2002106824A (fr) |
| TR (1) | TR200201182T2 (fr) |
| WO (1) | WO2001012205A2 (fr) |
| ZA (1) | ZA200201726B (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4147703A4 (fr) * | 2020-05-21 | 2023-11-08 | Osaka University | Agent thérapeutique contre le cancer épithélial |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2130796B1 (fr) | 2003-11-21 | 2016-10-19 | DermaTools Biotech GmbH | Des solutions aqueuses de composés chlores reactifs |
| WO2007009245A1 (fr) * | 2005-07-21 | 2007-01-25 | Nuvo Research Inc. | Solutions de chlorite stabilisees associees a des fluoropyrimidines pour traiter des cancers |
| EP2793860A1 (fr) | 2011-12-22 | 2014-10-29 | Nuvo Research GmbH | Compositions liposomales comprenant des chlorites ou chlorates |
| CN112386606A (zh) * | 2019-08-19 | 2021-02-23 | 卢序 | 一种有第二信使作用增加积极氧化压力的氧化剂的用途 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3515748A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Verwendung einer isotonen chloritmatrix-loesung bei der behandlung von tumoren |
| DE3515749A1 (de) * | 1985-05-02 | 1986-11-06 | Oxo Chemie GmbH, 6900 Heidelberg | Verwendung einer stabilisierten chloritmatrixloesung bei infektioesen zustaenden |
| WO1999017787A2 (fr) * | 1997-10-06 | 1999-04-15 | Oxo Chemie Ag | Utilisation de solution de chlorite stabilisee par voie chimique aux fins de l'inhibition d'une reponse immunitaire specifique d'un antigene |
| BR0008369A (pt) * | 1999-02-19 | 2001-11-06 | Kurt Wilhelm Stahl | ácido peroxiclórico, derivados de ânions, seus sais, e procedimento para a sua fabricação e aplicação |
-
2000
- 2000-08-18 CA CA002382293A patent/CA2382293A1/fr not_active Abandoned
- 2000-08-18 IL IL14818900A patent/IL148189A0/xx unknown
- 2000-08-18 CN CN00814063A patent/CN1378456A/zh active Pending
- 2000-08-18 TR TR2002/01182T patent/TR200201182T2/xx unknown
- 2000-08-18 PL PL00353769A patent/PL353769A1/xx unknown
- 2000-08-18 KR KR1020027002066A patent/KR20020038728A/ko not_active Withdrawn
- 2000-08-18 EP EP00957529A patent/EP1408994A2/fr not_active Withdrawn
- 2000-08-18 AU AU69132/00A patent/AU6913200A/en not_active Abandoned
- 2000-08-18 RU RU2002106824/14A patent/RU2002106824A/ru not_active Application Discontinuation
- 2000-08-18 WO PCT/US2000/022610 patent/WO2001012205A2/fr not_active Ceased
- 2000-08-18 NZ NZ517673A patent/NZ517673A/en not_active IP Right Cessation
- 2000-08-18 MX MXPA02001724A patent/MXPA02001724A/es unknown
-
2002
- 2002-02-15 NO NO20020751A patent/NO20020751L/no not_active Application Discontinuation
- 2002-03-01 ZA ZA200201726A patent/ZA200201726B/en unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4147703A4 (fr) * | 2020-05-21 | 2023-11-08 | Osaka University | Agent thérapeutique contre le cancer épithélial |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2002106824A (ru) | 2003-11-27 |
| AU6913200A (en) | 2001-03-13 |
| WO2001012205A3 (fr) | 2001-09-13 |
| IL148189A0 (en) | 2002-09-12 |
| TR200201182T2 (tr) | 2002-08-21 |
| EP1408994A2 (fr) | 2004-04-21 |
| KR20020038728A (ko) | 2002-05-23 |
| WO2001012205A2 (fr) | 2001-02-22 |
| NO20020751L (no) | 2002-04-17 |
| PL353769A1 (en) | 2003-12-01 |
| MXPA02001724A (es) | 2004-09-06 |
| NZ517673A (en) | 2004-03-26 |
| ZA200201726B (en) | 2003-12-31 |
| CN1378456A (zh) | 2002-11-06 |
| NO20020751D0 (no) | 2002-02-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |