CA2383814C - Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same - Google Patents

Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same Download PDF

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Publication number
CA2383814C
CA2383814C CA2383814A CA2383814A CA2383814C CA 2383814 C CA2383814 C CA 2383814C CA 2383814 A CA2383814 A CA 2383814A CA 2383814 A CA2383814 A CA 2383814A CA 2383814 C CA2383814 C CA 2383814C
Authority
CA
Canada
Prior art keywords
carnitine
alkanoyl
acid
tartrate
fumarate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2383814A
Other languages
English (en)
French (fr)
Other versions
CA2383814A1 (en
Inventor
Ken Hassen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Alfasigma SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26849378&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2383814(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Publication of CA2383814A1 publication Critical patent/CA2383814A1/en
Application granted granted Critical
Publication of CA2383814C publication Critical patent/CA2383814C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Nutrition Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Mycology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
CA2383814A 1999-09-03 2000-09-05 Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same Expired - Lifetime CA2383814C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15224099P 1999-09-03 1999-09-03
US60/152,240 1999-09-03
US15824599P 1999-10-08 1999-10-08
US60/158,245 1999-10-08
PCT/US2000/024279 WO2001017525A1 (en) 1999-09-03 2000-09-05 Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same

Publications (2)

Publication Number Publication Date
CA2383814A1 CA2383814A1 (en) 2001-03-15
CA2383814C true CA2383814C (en) 2010-08-17

Family

ID=26849378

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2383814A Expired - Lifetime CA2383814C (en) 1999-09-03 2000-09-05 Ultrafine l-carnitine, methods of preparing the same, compositions containing the same, and methods of using the same

Country Status (17)

Country Link
US (2) US20020111383A1 (de)
EP (1) EP1218001B1 (de)
JP (3) JP2003508488A (de)
KR (1) KR100827900B1 (de)
CN (1) CN1399549A (de)
AT (1) ATE418978T1 (de)
AU (1) AU770563B2 (de)
CA (1) CA2383814C (de)
CY (1) CY1110223T1 (de)
DE (1) DE60041269D1 (de)
DK (1) DK1218001T3 (de)
ES (1) ES2322328T3 (de)
HK (1) HK1047889B (de)
MX (1) MXPA02002327A (de)
NZ (1) NZ517597A (de)
PT (1) PT1218001E (de)
WO (1) WO2001017525A1 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002085134A1 (en) * 2001-04-24 2002-10-31 Lonza Ltd. Method of enhancing reproductive performance in sows
US7169770B2 (en) 2001-04-24 2007-01-30 Lonza Ltd. Method of enhancing reproductive performance in sows
DE10129502A1 (de) * 2001-06-19 2003-01-09 Beiersdorf Ag Verwendung von Carnitin und/oder einem oder mehreren Acyl-Carnitinen zur Herstellung von kosmetischen oder dermatologischen Zubereitungen zur Steigerung der Ceramidbiosynthese
US7977049B2 (en) * 2002-08-09 2011-07-12 President And Fellows Of Harvard College Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms
DE10350140A1 (de) * 2003-03-28 2004-10-14 Martin Schymura Fruchtgummizusammensetzung
JP2007530417A (ja) * 2003-07-01 2007-11-01 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 細胞及び生物の寿命及びストレス応答を操作するための組成物
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
US20050171027A1 (en) 2003-12-29 2005-08-04 President And Fellows Of Harvard College Compositions for treating or preventing obesity and insulin resistance disorders
JP4539096B2 (ja) * 2004-01-16 2010-09-08 日油株式会社 油性成分被覆ｌ−カルニチン塩粉末およびその用途
US20060084085A1 (en) * 2004-06-16 2006-04-20 Sinclair David A Methods and compositions for modulating Bax-mediated apoptosis
US20060014705A1 (en) * 2004-06-30 2006-01-19 Howitz Konrad T Compositions and methods for selectively activating human sirtuins
WO2006138418A2 (en) 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators
AU2006265280B2 (en) * 2005-07-05 2011-07-14 Lonza Ag Spray-drying process for producing a dry carnitine powder or granulate
DE102007009650A1 (de) 2007-02-26 2008-08-28 Beiersdorf Ag Kosmetisches Kombinationsprodukt zur Verbesserung des äußeren Erscheinungsbildes
DE102007009649A1 (de) 2007-02-26 2008-08-28 Beiersdorf Ag Nahrungsergänzungsmittel zur Pflege und/oder Verschönerung der Haut
US8466187B2 (en) 2007-09-18 2013-06-18 Thermolife International, Llc Amino acid compositions
CN101224202A (zh) * 2007-12-26 2008-07-23 广州康采恩医药有限公司 减肥组合物
US12612370B2 (en) 2011-03-02 2026-04-28 Thermolife International, Llc Amino acid compositions
DK3164125T3 (da) 2014-07-03 2023-12-18 Silti Ag Fremgangsmåder og sammensætninger til behandling af overvægt, forhindring af vægtforøgelse, fremme vægttab, fremme slankning eller behandling eller forebyggelse af udvikling af diabetes
WO2017105090A1 (ko) * 2015-12-14 2017-06-22 제이투에이치바이오텍 (주) 오로트산 l-카르니틴의 결정질 다형체, 이의 제조방법 또는 용도
EP3855944A4 (de) * 2018-10-29 2022-06-29 Lonza Consumer Health Inc. Verfahren und zusammensetzung zur erhöhung der bioverfügbarkeit von carnitin
CN112250588B (zh) * 2020-11-06 2023-03-31 哈尔滨工业大学（深圳） 一种左旋肉碱离子液体及其制备方法、应用
JP2024541338A (ja) 2020-11-12 2024-11-08 サーモライフ インターナショナル， エルエルシー 血中酸素飽和度を増大させる方法
AU2022220004A1 (en) 2021-02-11 2023-08-17 Thermolife International, Llc A method of administering nitric oxide gas

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1156852B (it) * 1978-07-10 1987-02-04 Sigma Tau Ind Farmaceuti Procedimento industriale per la preparazione del d'canforato della l carnitinammide e del d canforato della d carnitinammide e sue applicazioni
EP0150688B1 (de) * 1983-12-28 1987-04-22 Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. Salze von L-Carnitin und Alkanoyl-L-Carnitinen sowie Verfahren zur Herstellung derselben
IT1172394B (it) * 1983-12-28 1987-06-18 Sigma Tau Ind Farmaceuti Sali della l-carnitina e di alcuni alcanoil derivati della l-carnitina e procedimento per la loro preparazione
US5057597A (en) * 1990-07-03 1991-10-15 Koskan Larry P Process for the manufacture of anhydro polyamino acids and polyamino acids
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
JPH08259445A (ja) * 1995-01-27 1996-10-08 Takeda Chem Ind Ltd 胃排出能改善性医薬組成物
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
IT1289974B1 (it) * 1997-02-25 1998-10-19 Aldo Fassi Procedimento per la produzione di sali stabili e non igroscopici di l(-)carnitina e di alcanoli l(-)-carnitine
DE69704561T2 (de) * 1996-05-31 2001-08-09 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A., Rom/Roma Stabile nicht-hygroskopische salze von l(-)carnitin und alkanoyl-l(-)carnitinen,ein verfahren zu deren herstellung und feste, oral verabreichbare zusammensetzungen, die solche salze enthalten
US6488961B1 (en) * 1996-09-20 2002-12-03 Ethypharm, Inc. Effervescent granules and methods for their preparation
ATE223662T1 (de) * 1996-12-03 2002-09-15 Univ Kansas State Verwendung von carnitin-angereicherte futter für trächtige säue
IT1291113B1 (it) * 1997-03-20 1998-12-29 Sigma Tau Ind Farmaceuti Composizione nutritiva terapeutica per soggetti affetti da diabete mellito
US6149939A (en) * 1997-05-09 2000-11-21 Strumor; Mathew A. Healthful dissolvable oral tablets, and mini-bars
US6090848A (en) * 1997-12-01 2000-07-18 Sigma-Tau Healthscience S.P.A. Compositions and methods for increasing the concentration and/or motility of spermatozoa in humans
US6090849A (en) * 1999-03-23 2000-07-18 The Board Of Regents For Oklahoma State University Carnitine supplemented diet to prevent sudden death syndrome in breeder type poultry
IT1305308B1 (it) * 1999-03-26 2001-05-04 Biosint S P A Granulato ad alto contenuto di l-carnitina o alcanoil-l-carnitina,particolarmente adatto alla produzione di compresse per compressione
US6476010B2 (en) * 2000-03-10 2002-11-05 Hill's Pet Nutrition Method for increasing intestinal absorption of fat soluble vitamins in post-menopausal women and lower animals

Also Published As

Publication number Publication date
HK1047889A1 (en) 2003-03-14
CN1399549A (zh) 2003-02-26
WO2001017525A1 (en) 2001-03-15
US20020111383A1 (en) 2002-08-15
KR20020066322A (ko) 2002-08-14
PT1218001E (pt) 2009-03-31
AU770563B2 (en) 2004-02-26
ATE418978T1 (de) 2009-01-15
EP1218001B1 (de) 2008-12-31
KR100827900B1 (ko) 2008-05-07
HK1047889B (en) 2009-04-09
CA2383814A1 (en) 2001-03-15
EP1218001A1 (de) 2002-07-03
NZ517597A (en) 2003-11-28
AU7347000A (en) 2001-04-10
EP1218001A4 (de) 2005-05-18
US20050124558A1 (en) 2005-06-09
DK1218001T3 (da) 2009-04-14
US7303765B2 (en) 2007-12-04
DE60041269D1 (de) 2009-02-12
ES2322328T3 (es) 2009-06-19
JP2003508488A (ja) 2003-03-04
JP2013136635A (ja) 2013-07-11
CY1110223T1 (el) 2015-01-14
JP2009067809A (ja) 2009-04-02
MXPA02002327A (es) 2004-07-16

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Effective date: 20200908