CA2396796C - Preparations medicinales stabilisees contenant des particules d'aerosol - Google Patents
Preparations medicinales stabilisees contenant des particules d'aerosol Download PDFInfo
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- CA2396796C CA2396796C CA2396796A CA2396796A CA2396796C CA 2396796 C CA2396796 C CA 2396796C CA 2396796 A CA2396796 A CA 2396796A CA 2396796 A CA2396796 A CA 2396796A CA 2396796 C CA2396796 C CA 2396796C
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- 239000005020 polyethylene terephthalate Substances 0.000 description 1
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- 230000003389 potentiating effect Effects 0.000 description 1
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- NRKVKVQDUCJPIZ-MKAGXXMWSA-N pramlintide acetate Chemical compound C([C@@H](C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 NRKVKVQDUCJPIZ-MKAGXXMWSA-N 0.000 description 1
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- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 description 1
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- 125000000714 pyrimidinyl group Chemical group 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Otolaryngology (AREA)
- Pulmonology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Abstract
L'invention concerne une formulation aérosol médicale. Ladite formulation contient une quantité thérapeutique d'un médicament protéique ou peptidique, un fluide destiné à contenir ledit médicament ayant une taille moléculaire valant de 1 K Dalton à 150 K Dalton, un porteur fluidique destiné à contenir le médicament, et un stabilisateur pouvant être un acide aminé, un dérivé de cet acide aminé, ou un mélange de ceux-ci.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17798700P | 2000-01-25 | 2000-01-25 | |
| US60/177,987 | 2000-01-25 | ||
| US09/702,195 US6585957B1 (en) | 2000-01-25 | 2000-10-30 | Medicinal aerosol formulation |
| US09/702,195 | 2000-10-30 | ||
| PCT/US2001/000117 WO2001060420A1 (fr) | 2000-01-25 | 2001-01-02 | Formulation aerosol medicale |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2396796A1 CA2396796A1 (fr) | 2001-08-23 |
| CA2396796C true CA2396796C (fr) | 2011-06-21 |
Family
ID=26873842
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2396796A Expired - Fee Related CA2396796C (fr) | 2000-01-25 | 2001-01-02 | Preparations medicinales stabilisees contenant des particules d'aerosol |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1292283A4 (fr) |
| JP (1) | JP2003524646A (fr) |
| CN (1) | CN1440298A (fr) |
| AU (1) | AU783120B2 (fr) |
| CA (1) | CA2396796C (fr) |
| MX (1) | MXPA02007187A (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4707327B2 (ja) * | 2004-01-27 | 2011-06-22 | 旭化成ファーマ株式会社 | ポリペプタイド類の吸着防止剤 |
| ES2281222B1 (es) * | 2004-09-24 | 2008-06-01 | Grifols, S.A. | Utilizacion de alfa-1 antitripsina para la preparacion de medicamentos para el tratamiento de la fibromialgia. |
| EP2416156B1 (fr) | 2006-10-18 | 2015-12-30 | Periness Ltd. | Procédé pour le diagnostic de la fertilité masculine |
| EP3125942B8 (fr) * | 2014-04-03 | 2021-12-01 | CSL Behring AG | Nébulisation d'immunglobuline |
| CN104162142A (zh) * | 2014-08-29 | 2014-11-26 | 宁波市微循环与莨菪类药研究所 | N-乙酰天门冬氨酰谷氨酸二肽制剂在海洛因成瘾治疗中的应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE76311T1 (de) * | 1986-08-19 | 1992-06-15 | Genentech Inc | Einrichtung und dispersion zum intrapulmonalen eingeben von polypeptidwuchsstoffen und zytokinen. |
| ES2122261T3 (es) * | 1993-03-17 | 1998-12-16 | Minnesota Mining & Mfg | Formulacion de aerosol que contiene un adyuvante de dispersion derivado de un ester, una amida o un mercaptoester. |
| ATE416755T1 (de) * | 1994-03-07 | 2008-12-15 | Nektar Therapeutics | Verfahren und zusammensetzung für die pulmonale darreichung von insulin |
| US6136294C1 (en) * | 1998-09-22 | 2002-09-24 | Aeropharm Technology Inc | Amino acid stabilized medical aerosol formulation |
| SK11142002A3 (sk) * | 1999-12-30 | 2004-09-08 | Chiron Corporation | Liečivo na podávanie interleukínu-2 a stabilizovaný lyofilizovaný alebo sprejovo sušený farmaceutický prostriedok s obsahom interleukínu-2 |
-
2001
- 2001-01-02 CN CN01807195A patent/CN1440298A/zh active Pending
- 2001-01-02 JP JP2001559515A patent/JP2003524646A/ja active Pending
- 2001-01-02 EP EP01901681A patent/EP1292283A4/fr not_active Withdrawn
- 2001-01-02 AU AU27559/01A patent/AU783120B2/en not_active Ceased
- 2001-01-02 MX MXPA02007187A patent/MXPA02007187A/es active IP Right Grant
- 2001-01-02 CA CA2396796A patent/CA2396796C/fr not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1440298A (zh) | 2003-09-03 |
| EP1292283A1 (fr) | 2003-03-19 |
| CA2396796A1 (fr) | 2001-08-23 |
| JP2003524646A (ja) | 2003-08-19 |
| AU783120B2 (en) | 2005-09-29 |
| AU2755901A (en) | 2001-08-27 |
| EP1292283A4 (fr) | 2003-03-19 |
| MXPA02007187A (es) | 2002-12-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20130102 |