CA2405104A1 - Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches - Google Patents

Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches Download PDF

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Publication number
CA2405104A1
CA2405104A1 CA002405104A CA2405104A CA2405104A1 CA 2405104 A1 CA2405104 A1 CA 2405104A1 CA 002405104 A CA002405104 A CA 002405104A CA 2405104 A CA2405104 A CA 2405104A CA 2405104 A1 CA2405104 A1 CA 2405104A1
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CA
Canada
Prior art keywords
polypeptide
seq
amino acid
polynucleotide
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002405104A
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English (en)
Inventor
Tom Y. Tang
Ivan Labat
Radoje T. Drmanac
Nancy K. Mize
Mitsuo Nishikawa
Cheng-Chi Chao
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Individual
Original Assignee
Kirin Brewery Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kirin Brewery Co Ltd filed Critical Kirin Brewery Co Ltd
Publication of CA2405104A1 publication Critical patent/CA2405104A1/fr
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Zoology (AREA)
  • Transplantation (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne de nouveaux polynucl~otides et polypeptides cod~s par ces polynucl~otides et des mutants ou variants de ceux-ci qui correspondent ~ un nouveau polypeptide s~cr~t~ humain du type facteur de croissance de cellules souches. Ces polynucl~otides comprennent des s~quences d'acide nucl~ique isol~es ~ partir de biblioth­ques d'ADNc pr~par~es ~ partir de cellules de testicules humains (num~ros d'identification de clone Hyseq 2880984 et 2881695), de peau de foetus humains (num~ro d'identification de clone Hyseq 15375176), de rates d'adulte (num~ro d'identification de clone Hyseq 14856094) et de cellules endoth~liales humaines (num~ros d'identification de clone Hyseq 13804756, 13687487, 13804756). D'autres aspects de l'invention concernent des vecteurs contenant des processus pour produire de nouveaux polypeptides humains du type facteur de croissance de cellules souches, ainsi que des anticorps sp~cifiques de ces polypeptides.
CA002405104A 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches Abandoned CA2405104A1 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US54377400A 2000-04-05 2000-04-05
US09/543,774 2000-04-05
US21573300P 2000-06-28 2000-06-28
US60/215,733 2000-06-28
US75756201A 2001-01-09 2001-01-09
US09/757,562 2001-01-09
US26661401P 2001-02-05 2001-02-05
US60/266,614 2001-02-05
PCT/US2001/011208 WO2001077169A2 (fr) 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches

Publications (1)

Publication Number Publication Date
CA2405104A1 true CA2405104A1 (fr) 2001-10-18

Family

ID=27499020

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002405104A Abandoned CA2405104A1 (fr) 2000-04-05 2001-04-05 Methodes et materiaux relatifs a de nouveaux polypeptides et polynucleotides du type facteur de croissance des cellules-souches

Country Status (5)

Country Link
EP (1) EP1268543A2 (fr)
JP (1) JP2003530124A (fr)
AU (1) AU5904101A (fr)
CA (1) CA2405104A1 (fr)
WO (1) WO2001077169A2 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7411052B2 (en) 2001-03-05 2008-08-12 Nuvelo, Inc. Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
JP2005514917A (ja) * 2001-10-03 2005-05-26 インサイト・ゲノミックス・インコーポレイテッド 分泌タンパク質
EP2093298A3 (fr) 2003-10-10 2009-09-23 Deutsches Krebsforschungszentrum Compositions pour le diagnostic et la thérapie des maladies associées à l'expression aberrante de futrines (R-Spondins)
RU2343158C2 (ru) * 2004-01-27 2009-01-10 Ньювело, Инк. Желудочно-кишечный пролиферативный фактор и его применения
US7541431B2 (en) 2005-09-07 2009-06-02 Maine Medical Center Cristin/R-spondin ligands active in the Wnt signaling pathway and methods, compositions and kits relating thereto
US20090118176A1 (en) * 2005-10-07 2009-05-07 Emtage Peter C R Stem Cell Factor-Like Protein Scfa1 and Uses Thereof
HUE028379T2 (en) 2006-09-29 2016-12-28 Oncomed Pharm Inc Preparations and procedures for the diagnosis and treatment of cancer
DK2081586T4 (en) 2006-10-20 2019-01-21 Deutsches Krebsforschungszentrum Stiftung Des Oeffentlichen Rechts Rspondins as modulators of angiogenesis and vasculogenesis
WO2008075796A1 (fr) * 2006-12-21 2008-06-26 Kyowa Hakko Kirin Co., Ltd. Agent pour encourager la récupération après une déplétion de globule sanguin
HRP20151261T1 (hr) 2007-07-02 2016-01-01 Oncomed Pharmaceuticals, Inc. Sastavi i postupci za lijeäśenje i dijagnosticiranje raka
EP2412800A1 (fr) 2010-07-29 2012-02-01 Koninklijke Nederlandse Akademie van Wetenschappen Organoïde du foie, ses utilisations et son procédé de culture pour l'obtenir
CN102439135B (zh) 2009-02-03 2014-04-30 荷兰皇家科学院 用于上皮干细胞和包含所述干细胞的类器官的培养基
US9752124B2 (en) 2009-02-03 2017-09-05 Koninklijke Nederlandse Akademie Van Wetenschappen Culture medium for epithelial stem cells and organoids comprising the stem cells
EP2419133A1 (fr) 2009-04-15 2012-02-22 Deutsches Krebsforschungszentrum Inhibition de la rspondine-3 dans des troubles osseux
US8551479B2 (en) 2010-09-10 2013-10-08 Oncomed Pharmaceuticals, Inc. Methods for treating melanoma
JP6185463B2 (ja) 2011-07-15 2017-08-23 オンコメッド ファーマシューティカルズ インコーポレイテッド Ｒｓｐｏ結合剤およびその使用法
KR102100307B1 (ko) * 2012-03-21 2020-04-14 다나-파버 캔서 인스티튜트 인크. 인간 림프 기관-유래 억제성 기질 세포의 분리 및 용도
EA032038B1 (ru) 2012-07-13 2019-03-29 Онкомед Фармасьютикалс, Инк. Rspo3-связывающие агенты и их применение
JP2017528523A (ja) 2014-09-16 2017-09-28 オンコメッド ファーマシューティカルズ インコーポレイテッド 線維性疾患の治療
GB201721615D0 (en) 2017-12-21 2018-02-07 Koninklijke Nederlandse Akademie Van Wetenschappen Immune cell organoid co-cultures
CN108607101A (zh) * 2018-05-04 2018-10-02 广西中医药大学附属瑞康医院 Zip1基因在制备抑制骨髓间充质干细胞凋亡的产品中的应用
CN111420034A (zh) * 2019-01-08 2020-07-17 上海莱馥医疗科技有限公司 一种用于治疗银屑病的混合干细胞制剂及其制备方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0977853A1 (fr) * 1997-04-25 2000-02-09 Genetics Institute, Inc. Proteines secretees et polynucleotides les codant
EP1169333A1 (fr) * 1999-03-19 2002-01-09 Human Genome Sciences, Inc. Proteines humaines secretees (49)
CN1297930A (zh) * 1999-11-29 2001-06-06 上海博容基因开发有限公司 一种新的多肽——人凝血栓蛋白30和编码这种多肽的多核苷酸
CA2399776A1 (fr) * 2000-02-03 2001-08-09 Hyseq, Inc. Acides nucleiques et polypeptides

Also Published As

Publication number Publication date
EP1268543A2 (fr) 2003-01-02
JP2003530124A (ja) 2003-10-14
WO2001077169A2 (fr) 2001-10-18
WO2001077169A9 (fr) 2002-12-19
AU5904101A (en) 2001-10-23
WO2001077169A3 (fr) 2002-07-04

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