CA2406396A1 - Nouveaux derives amino carboxy alkyle d'acide barbiturique - Google Patents

Nouveaux derives amino carboxy alkyle d'acide barbiturique Download PDF

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Publication number
CA2406396A1
CA2406396A1 CA002406396A CA2406396A CA2406396A1 CA 2406396 A1 CA2406396 A1 CA 2406396A1 CA 002406396 A CA002406396 A CA 002406396A CA 2406396 A CA2406396 A CA 2406396A CA 2406396 A1 CA2406396 A1 CA 2406396A1
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CA
Canada
Prior art keywords
group
compound
formula
cooh
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002406396A
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English (en)
Inventor
Kenneth Curry
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CA002306170A external-priority patent/CA2306170A1/fr
Application filed by Individual filed Critical Individual
Priority to CA002406396A priority Critical patent/CA2406396A1/fr
Publication of CA2406396A1 publication Critical patent/CA2406396A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/62—Barbituric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C07D239/66—Thiobarbituric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Psychiatry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Cette invention concerne de nouveaux dérivés amino, carboxy, alkyle d'acide barbiturique thérapeutiquement actifs, représentés par la formule (I), dans laquelle au moins un élément parmi R1, R2, R3 ou R4 comprend un groupe caractéristique NH¿2? et au moins un élément parmi R1, R2, R3 ou R4 comprend un groupe caractéristique COOH. Cette invention concerne également un procédé de préparation des composés de formule (I), ainsi que des compositions pharmaceutiques comprenant ces composés. Ces nouveaux composés agissent comme des modulateurs des récepteurs du glutamate métabotropique et, en tant que tels, sont utiles dans le traitement de maladies du système nerveux central liées au système des récepteurs du glutamate métabotropique.
CA002406396A 2000-04-18 2001-04-18 Nouveaux derives amino carboxy alkyle d'acide barbiturique Abandoned CA2406396A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002406396A CA2406396A1 (fr) 2000-04-18 2001-04-18 Nouveaux derives amino carboxy alkyle d'acide barbiturique

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CA2,306,170 2000-04-18
CA002306170A CA2306170A1 (fr) 2000-04-18 2000-04-18 Nouveaux derives amines et carboxyles de l'acide barbiturique
CA002406396A CA2406396A1 (fr) 2000-04-18 2001-04-18 Nouveaux derives amino carboxy alkyle d'acide barbiturique
PCT/CA2001/000503 WO2001079185A1 (fr) 2000-04-18 2001-04-18 Nouveaux derives amino carboxy alkyle d'acide barbiturique

Publications (1)

Publication Number Publication Date
CA2406396A1 true CA2406396A1 (fr) 2001-10-25

Family

ID=25681739

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002406396A Abandoned CA2406396A1 (fr) 2000-04-18 2001-04-18 Nouveaux derives amino carboxy alkyle d'acide barbiturique

Country Status (1)

Country Link
CA (1) CA2406396A1 (fr)

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