CA2407450A1 - Agents d'imagerie par resonance magnetique utilises pour apporter des agents therapeutiques - Google Patents

Agents d'imagerie par resonance magnetique utilises pour apporter des agents therapeutiques Download PDF

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Publication number
CA2407450A1
CA2407450A1 CA002407450A CA2407450A CA2407450A1 CA 2407450 A1 CA2407450 A1 CA 2407450A1 CA 002407450 A CA002407450 A CA 002407450A CA 2407450 A CA2407450 A CA 2407450A CA 2407450 A1 CA2407450 A1 CA 2407450A1
Authority
CA
Canada
Prior art keywords
iii
metal ion
blocking moiety
therapeutic blocking
moiety
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002407450A
Other languages
English (en)
Inventor
Thomas J. Meade
Scott Fraser
Russell Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Research Corp Technologies Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/716,178 external-priority patent/US6713045B1/en
Application filed by Individual filed Critical Individual
Publication of CA2407450A1 publication Critical patent/CA2407450A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
    • A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
    • A61K49/105—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA the metal complex being Gd-DTPA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
    • A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA

Landscapes

  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)

Abstract

La présente invention concerne de nouveaux agents de contraste pour l'imagerie par résonance magnétique qui rendent compte d'événements physiologiques sous une forme conditionnelle et qui détectent simultanément l'apport et/ou l'activation d'un agent actif du point de vue thérapeutique.
CA002407450A 2000-05-04 2001-05-04 Agents d'imagerie par resonance magnetique utilises pour apporter des agents therapeutiques Abandoned CA2407450A1 (fr)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
US20210800P 2000-05-04 2000-05-04
US20181700P 2000-05-04 2000-05-04
US60/201,817 2000-05-04
US60/202,108 2000-05-04
US20322400P 2000-05-05 2000-05-05
US60/203,224 2000-05-05
US71617500A 2000-11-16 2000-11-16
US09/716,175 2000-11-16
US09/716,178 2000-11-16
US09/716,178 US6713045B1 (en) 1995-06-02 2000-11-16 Targeted magnetic resonance imaging agents for the detection of physiological processes
PCT/US2001/014665 WO2001082795A2 (fr) 2000-05-04 2001-05-04 Agents d'imagerie par resonance magnetique utilises pour apporter des agents therapeutiques

Publications (1)

Publication Number Publication Date
CA2407450A1 true CA2407450A1 (fr) 2001-11-08

Family

ID=27539457

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002407450A Abandoned CA2407450A1 (fr) 2000-05-04 2001-05-04 Agents d'imagerie par resonance magnetique utilises pour apporter des agents therapeutiques

Country Status (4)

Country Link
EP (1) EP1278553A2 (fr)
AU (1) AU2001259575A1 (fr)
CA (1) CA2407450A1 (fr)
WO (1) WO2001082795A2 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6713045B1 (en) 1995-06-02 2004-03-30 Research Corporation Technologies, Inc. Targeted magnetic resonance imaging agents for the detection of physiological processes
AU752812B2 (en) 1997-11-17 2002-10-03 Research Corporation Technologies, Inc. Magnetic resonance imaging agents for the detection of physiological agents
US6673333B1 (en) 2000-05-04 2004-01-06 Research Corporation Technologies, Inc. Functional MRI agents for cancer imaging
EP4059925A1 (fr) 2021-03-15 2022-09-21 Bayer Aktiengesellschaft Nouvel agent de contraste pour une utilisation dans l'imagerie par résonance magnétique
EP4335462A1 (fr) 2022-09-09 2024-03-13 Bayer AG Nouveaux agents de contraste pour l'imagerie diagnostique par tomodensitometrie
EP4335840A1 (fr) 2022-09-09 2024-03-13 Bayer Aktiengesellschaft Nouveaux agents de contraste pour l'imagerie diagnostique

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707605A (en) * 1995-06-02 1998-01-13 Research Corporation Technologies Magnetic resonance imaging agents for the detection of physiological agents
AU726914B2 (en) * 1996-04-01 2000-11-23 Epix Pharmaceuticals, Inc. Bioactivated diagnostic imaging contrast agents
DE69811931T2 (de) * 1997-10-27 2003-12-18 Research Corp. Technologies, Inc. Mri-mittel für die verabreichung von therapeutischen mitteln
US6093382A (en) * 1998-05-16 2000-07-25 Bracco Research Usa Inc. Metal complexes derivatized with folate for use in diagnostic and therapeutic applications

Also Published As

Publication number Publication date
WO2001082795A3 (fr) 2002-05-02
EP1278553A2 (fr) 2003-01-29
WO2001082795A2 (fr) 2001-11-08
AU2001259575A1 (en) 2001-11-12

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Legal Events

Date Code Title Description
FZDE Discontinued