CA2407957C - Spectrometre de masse - Google Patents
Spectrometre de masse Download PDFInfo
- Publication number
- CA2407957C CA2407957C CA2407957A CA2407957A CA2407957C CA 2407957 C CA2407957 C CA 2407957C CA 2407957 A CA2407957 A CA 2407957A CA 2407957 A CA2407957 A CA 2407957A CA 2407957 C CA2407957 C CA 2407957C
- Authority
- CA
- Canada
- Prior art keywords
- ions
- mass
- ion
- fragment
- spectrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000002500 ions Chemical class 0.000 claims abstract description 669
- 238000005040 ion trap Methods 0.000 claims abstract description 171
- 239000012634 fragment Substances 0.000 claims abstract description 99
- 238000011144 upstream manufacturing Methods 0.000 claims abstract description 66
- 238000000034 method Methods 0.000 claims description 53
- 238000001914 filtration Methods 0.000 claims description 26
- 238000004949 mass spectrometry Methods 0.000 claims description 18
- 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims description 11
- 238000005086 pumping Methods 0.000 claims description 8
- 230000001133 acceleration Effects 0.000 claims description 7
- 238000000766 differential mobility spectroscopy Methods 0.000 claims description 7
- 238000001698 laser desorption ionisation Methods 0.000 claims description 4
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 3
- 101000823051 Homo sapiens Amyloid-beta precursor protein Proteins 0.000 claims description 3
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 3
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 claims description 3
- 238000000451 chemical ionisation Methods 0.000 claims description 3
- 239000002243 precursor Substances 0.000 abstract description 17
- 238000004458 analytical method Methods 0.000 abstract description 6
- 230000037230 mobility Effects 0.000 description 108
- 101100204059 Caenorhabditis elegans trap-2 gene Proteins 0.000 description 36
- 239000007789 gas Substances 0.000 description 33
- 108010063955 thrombin receptor peptide (42-47) Proteins 0.000 description 21
- 108090000623 proteins and genes Proteins 0.000 description 9
- 238000001819 mass spectrum Methods 0.000 description 7
- 102000004169 proteins and genes Human genes 0.000 description 7
- 230000035945 sensitivity Effects 0.000 description 6
- 230000002238 attenuated effect Effects 0.000 description 4
- 238000013467 fragmentation Methods 0.000 description 4
- 238000006062 fragmentation reaction Methods 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 238000001514 detection method Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000000926 separation method Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 230000001360 synchronised effect Effects 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 150000001450 anions Chemical class 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 238000000132 electrospray ionisation Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 238000004885 tandem mass spectrometry Methods 0.000 description 2
- 230000002123 temporal effect Effects 0.000 description 2
- 238000004252 FT/ICR mass spectrometry Methods 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 101800001442 Peptide pr Proteins 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010026552 Proteome Proteins 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000003990 capacitor Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000001351 cycling effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- -1 doubly Chemical class 0.000 description 1
- 235000012489 doughnuts Nutrition 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
Classifications
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/4205—Device types
- H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
- H01J49/4215—Quadrupole mass filters
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
-
- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/26—Mass spectrometers or separator tubes
- H01J49/34—Dynamic spectrometers
- H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
- H01J49/426—Methods for controlling ions
Landscapes
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Electron Tubes For Measurement (AREA)
Abstract
Spectromètre de masse dans lequel des ions à l'état de charge souhaité sont sélectionnés par un spectromètre de mobilité ionique (4) en combinaison à un filtre de masse quadripolaire (5). Les ions précurseurs sont fragmentés ou subissent une réaction pour former des ions produits dans une cellule de collision servant de piège à ions (6), puis sont renvoyés dans un piège à ions en amont (2). Les ions fragmentés ou produits passent ensuite à travers le spectromètre de mobilité ionique (4), où ils sont temporairement séparés en fonction de leur mobilité ionique. Les ions fragmentés ou produits sont ensuite piégés de nouveau dans la cellule de collision servant de piège à ions (6) avant d'en être libérés par paquets. L'électrode « pousseur » (8) de l'analyseur de masse à temps de vol est mis sous tension sur une période déterminée après qu'un paquet d'ions est libéré du piège à ions avec cellule de collision (6). Par conséquent, il est possible de sélectionner des ions précurseurs à multiples charges dans un milieu de particules à charge unique, de les fragmenter, puis de faire une analyse de masse des ions fragmentés avec un coefficient d'utilisation de presque 100 % sur toute la portée massique.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0211373.6 | 2002-05-17 | ||
| GBGB0211373.6A GB0211373D0 (en) | 2002-05-17 | 2002-05-17 | Mass spectrometer |
| GB0212641.5 | 2002-05-31 | ||
| GBGB0212641.5A GB0212641D0 (en) | 2002-05-17 | 2002-05-31 | Mass spectrometer |
| GB0222055.6 | 2002-09-23 | ||
| GB0222055A GB2389704B (en) | 2002-05-17 | 2002-09-23 | Mass Spectrometer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2407957A1 CA2407957A1 (fr) | 2003-11-17 |
| CA2407957C true CA2407957C (fr) | 2010-12-14 |
Family
ID=29407326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2407957A Expired - Fee Related CA2407957C (fr) | 2002-05-17 | 2002-10-11 | Spectrometre de masse |
Country Status (3)
| Country | Link |
|---|---|
| EP (2) | EP1365438B1 (fr) |
| CA (1) | CA2407957C (fr) |
| GB (1) | GB2390478B (fr) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2390478B (en) * | 2002-05-17 | 2004-06-02 | Micromass Ltd | Mass spectrometer |
| US7064319B2 (en) * | 2003-03-31 | 2006-06-20 | Hitachi High-Technologies Corporation | Mass spectrometer |
| DE102004014582B4 (de) * | 2004-03-25 | 2009-08-20 | Bruker Daltonik Gmbh | Ionenoptische Phasenvolumenkomprimierung |
| GB0408751D0 (en) * | 2004-04-20 | 2004-05-26 | Micromass Ltd | Mass spectrometer |
| GB0424426D0 (en) | 2004-11-04 | 2004-12-08 | Micromass Ltd | Mass spectrometer |
| GB0801309D0 (en) | 2008-01-24 | 2008-03-05 | Micromass Ltd | Mass spectrometer |
| WO2015071647A2 (fr) * | 2013-11-12 | 2015-05-21 | Micromass Uk Limited | Procédé d'isolement d'ions |
| GB201319952D0 (en) * | 2013-11-12 | 2013-12-25 | Micromass Ltd | Methods of isolating ions |
| EP3069371B1 (fr) * | 2013-11-12 | 2023-01-04 | Micromass UK Limited | Spectromètres de masse à piège à ions |
| GB201410346D0 (en) * | 2014-06-11 | 2014-07-23 | Micromass Ltd | Two dimensional msms acquisition modes |
| DE112015002731B4 (de) | 2014-06-11 | 2024-03-28 | Micromass Uk Limited | Zweidimensionale MS/MS-Erfassungsmodi |
| US9147565B1 (en) * | 2014-12-30 | 2015-09-29 | Morpho Detection, Llc | Ion mobility spectrometer and method of using the same |
| EP3926340B1 (fr) * | 2015-04-23 | 2025-04-16 | Micromass UK Limited | Séparation d'ions dans un piège à ions |
| US10832897B2 (en) * | 2018-10-19 | 2020-11-10 | Thermo Finnigan Llc | Methods and devices for high-throughput data independent analysis for mass spectrometry using parallel arrays of cells |
| CN109755096B (zh) * | 2018-12-31 | 2020-11-06 | 聚光科技(杭州)股份有限公司 | 筛选式飞行时间质谱仪及检测方法 |
| US11293898B2 (en) | 2020-02-06 | 2022-04-05 | Thermo Finnigan Llc | Duty cycle improvement for a mass spectrometer using ion mobility separation |
| US12235239B2 (en) * | 2022-04-05 | 2025-02-25 | Thermo Finnigan Llc | Ion mobility enhanced qualitative and quantitative methods |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5689111A (en) * | 1995-08-10 | 1997-11-18 | Analytica Of Branford, Inc. | Ion storage time-of-flight mass spectrometer |
| US6960761B2 (en) * | 1997-06-02 | 2005-11-01 | Advanced Research & Technology Institute | Instrument for separating ions in time as functions of preselected ion mobility and ion mass |
| US6323482B1 (en) * | 1997-06-02 | 2001-11-27 | Advanced Research And Technology Institute, Inc. | Ion mobility and mass spectrometer |
| US6498342B1 (en) | 1997-06-02 | 2002-12-24 | Advanced Research & Technology Institute | Ion separation instrument |
| CA2318855C (fr) * | 1998-01-23 | 2006-07-11 | Analytica Of Branford, Inc. | Spectrometrie de masse a guide d'ions multipolaire |
| CA2391060C (fr) * | 2001-06-21 | 2011-08-09 | Micromass Limited | Spectrometre de masse |
| GB2390478B (en) * | 2002-05-17 | 2004-06-02 | Micromass Ltd | Mass spectrometer |
-
2002
- 2002-09-23 GB GB0321698A patent/GB2390478B/en not_active Expired - Lifetime
- 2002-10-11 CA CA2407957A patent/CA2407957C/fr not_active Expired - Fee Related
- 2002-10-14 EP EP02257117A patent/EP1365438B1/fr not_active Expired - Lifetime
- 2002-10-14 EP EP08013533A patent/EP2001039B1/fr not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1365438A3 (fr) | 2006-04-12 |
| CA2407957A1 (fr) | 2003-11-17 |
| GB0321698D0 (en) | 2003-10-15 |
| GB2390478A (en) | 2004-01-07 |
| EP2001039B1 (fr) | 2012-03-28 |
| EP2001039A1 (fr) | 2008-12-10 |
| EP1365438B1 (fr) | 2010-09-08 |
| EP1365438A2 (fr) | 2003-11-26 |
| GB2390478B (en) | 2004-06-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US6906319B2 (en) | Mass spectrometer | |
| US7586088B2 (en) | Mass spectrometer and method of mass spectrometry | |
| EP1942340B1 (fr) | Spectromètre à mobilité ionique | |
| US6992283B2 (en) | Mass spectrometer | |
| GB2389704A (en) | An ion mobility spectrometer coupled to a scanning mass filter and fragmentation cell | |
| CA2407957C (fr) | Spectrometre de masse | |
| CA2349416C (fr) | Amelioration des methodes de balayage ms/ms pour spectrometre de masse tandem quadripolaire/a temps de vol | |
| US9099289B2 (en) | Targeted analysis for tandem mass spectrometry | |
| EP2913840B1 (fr) | Spectromètre de masse | |
| US7692143B2 (en) | Method for axial ejection and in-trap fragmentation using auxiliary electrodes in a multipole mass spectrometer | |
| JP5329967B2 (ja) | 質量分析計 | |
| CA2453852C (fr) | Spectrometre de masse | |
| US9576779B2 (en) | System and method for quantitation in mass spectrometry | |
| CA2714930C (fr) | Spectrometre de masse | |
| GB2392305A (en) | An ion tunnel ion mobility spectrometer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20201013 |