CA2408103A1 - Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers - Google Patents
Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers Download PDFInfo
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- CA2408103A1 CA2408103A1 CA002408103A CA2408103A CA2408103A1 CA 2408103 A1 CA2408103 A1 CA 2408103A1 CA 002408103 A CA002408103 A CA 002408103A CA 2408103 A CA2408103 A CA 2408103A CA 2408103 A1 CA2408103 A1 CA 2408103A1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La présente invention concerne de nouveaux composés de promédicaments, des compositions renfermant les composés de promédicaments précités, des procédés de fabrication des composés de promédicaments précités et des procédés d'utilisation de ces derniers. Les composés de promédicaments de l'invention comprennent une entité biologiquement active liée à un fragment masquant via un fragment de liaison. Les composés de promédicaments de l'invention sont sélectivement activés sur les cellules cibles ou à proximité de celles-ci et ils présentent une toxicité inférieure et, éventuellement, une demi-vie sérique ou in vivo plus longue que l'entité biologiquement active correspondante pure.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20899600P | 2000-06-01 | 2000-06-01 | |
| US60/208,996 | 2000-06-01 | ||
| EP00870130.2 | 2000-06-15 | ||
| EP00870130 | 2000-06-15 | ||
| EP00870306.8 | 2000-12-18 | ||
| EP00870306 | 2000-12-18 | ||
| PCT/EP2001/006106 WO2001091798A2 (fr) | 2000-06-01 | 2001-05-29 | Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2408103A1 true CA2408103A1 (fr) | 2001-12-06 |
Family
ID=27223761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002408103A Abandoned CA2408103A1 (fr) | 2000-06-01 | 2001-05-29 | Composes de promedicaments a activation tumorale et procedes de fabrication et d'utilisation de ces derniers |
Country Status (3)
| Country | Link |
|---|---|
| JP (1) | JP2003534387A (fr) |
| AU (1) | AU2001279630A1 (fr) |
| CA (1) | CA2408103A1 (fr) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10059762B2 (en) | 2009-01-12 | 2018-08-28 | Cytomx Therapeutics, Inc. | Anti-EGFR activatable antibodies |
| US10800850B2 (en) | 2000-10-09 | 2020-10-13 | Cytomx Therapeutics, Inc. | Therapeutic antibodies |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090304719A1 (en) * | 2007-08-22 | 2009-12-10 | Patrick Daugherty | Activatable binding polypeptides and methods of identification and use thereof |
| KR101619816B1 (ko) | 2009-01-19 | 2016-05-13 | 한미사이언스 주식회사 | 면역글로불린 Ｆｃ 단편을 포함하는 올리고뉴클레오타이드 결합체 |
| US8399219B2 (en) * | 2009-02-23 | 2013-03-19 | Cytomx Therapeutics, Inc. | Protease activatable interferon alpha proprotein |
| WO2019091384A1 (fr) * | 2017-11-08 | 2019-05-16 | Yafei Shanghai Biolog Medicine Science & Technology Co., Ltd. | Conjugués à base d'une biomolécule et leur utilisation |
-
2001
- 2001-05-29 JP JP2001587810A patent/JP2003534387A/ja not_active Withdrawn
- 2001-05-29 CA CA002408103A patent/CA2408103A1/fr not_active Abandoned
- 2001-05-29 AU AU2001279630A patent/AU2001279630A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10800850B2 (en) | 2000-10-09 | 2020-10-13 | Cytomx Therapeutics, Inc. | Therapeutic antibodies |
| US10059762B2 (en) | 2009-01-12 | 2018-08-28 | Cytomx Therapeutics, Inc. | Anti-EGFR activatable antibodies |
| US10118961B2 (en) | 2009-01-12 | 2018-11-06 | Cytomx Therapeutics, Inc. | Modified antibody containing the cleavable peptide with the amino acid sequence TGRGPSWV |
| US10875913B2 (en) | 2009-01-12 | 2020-12-29 | Cytomx Therapeutics, Inc. | Methods of treatment using activatable anti-EGFR antibodies |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2003534387A (ja) | 2003-11-18 |
| AU2001279630A1 (en) | 2001-12-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |