CA2408689A1 - Creme pour la peau contenant de l'allantoine - Google Patents
Creme pour la peau contenant de l'allantoine Download PDFInfo
- Publication number
- CA2408689A1 CA2408689A1 CA002408689A CA2408689A CA2408689A1 CA 2408689 A1 CA2408689 A1 CA 2408689A1 CA 002408689 A CA002408689 A CA 002408689A CA 2408689 A CA2408689 A CA 2408689A CA 2408689 A1 CA2408689 A1 CA 2408689A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- oil
- allantoin
- group
- methylparaben
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 title claims abstract description 210
- POJWUDADGALRAB-PVQJCKRUSA-N Allantoin Natural products NC(=O)N[C@@H]1NC(=O)NC1=O POJWUDADGALRAB-PVQJCKRUSA-N 0.000 title claims abstract description 105
- 229960000458 allantoin Drugs 0.000 title claims abstract description 105
- 239000002884 skin cream Substances 0.000 title abstract description 29
- 239000000203 mixture Substances 0.000 claims abstract description 575
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 70
- 239000002904 solvent Substances 0.000 claims abstract description 52
- 239000003755 preservative agent Substances 0.000 claims abstract description 51
- 230000002335 preservative effect Effects 0.000 claims abstract description 49
- 239000003974 emollient agent Substances 0.000 claims abstract description 48
- SATHPVQTSSUFFW-UHFFFAOYSA-N 4-[6-[(3,5-dihydroxy-4-methoxyoxan-2-yl)oxymethyl]-3,5-dihydroxy-4-methoxyoxan-2-yl]oxy-2-(hydroxymethyl)-6-methyloxane-3,5-diol Chemical compound OC1C(OC)C(O)COC1OCC1C(O)C(OC)C(O)C(OC2C(C(CO)OC(C)C2O)O)O1 SATHPVQTSSUFFW-UHFFFAOYSA-N 0.000 claims abstract description 37
- 229940082009 galactoarabinan Drugs 0.000 claims abstract description 37
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 34
- 239000012874 anionic emulsifier Substances 0.000 claims abstract description 33
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical group OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 32
- 229940096529 carboxypolymethylene Drugs 0.000 claims abstract description 29
- 229920000642 polymer Polymers 0.000 claims abstract description 29
- 230000002378 acidificating effect Effects 0.000 claims abstract description 28
- 229920006318 anionic polymer Polymers 0.000 claims abstract description 28
- 239000012875 nonionic emulsifier Substances 0.000 claims abstract description 20
- 229920000499 poly(galactose) polymer Polymers 0.000 claims abstract description 12
- 125000000129 anionic group Chemical group 0.000 claims abstract description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 225
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 claims description 154
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 148
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims description 144
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 141
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 claims description 99
- 229960000541 cetyl alcohol Drugs 0.000 claims description 77
- 239000003205 fragrance Substances 0.000 claims description 75
- 239000003921 oil Substances 0.000 claims description 75
- 235000019198 oils Nutrition 0.000 claims description 75
- 239000003026 cod liver oil Substances 0.000 claims description 74
- 235000012716 cod liver oil Nutrition 0.000 claims description 74
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 74
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 74
- 229960002216 methylparaben Drugs 0.000 claims description 74
- 239000004166 Lanolin Substances 0.000 claims description 73
- 235000019388 lanolin Nutrition 0.000 claims description 73
- 229940039717 lanolin Drugs 0.000 claims description 73
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims description 72
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims description 72
- 229960003415 propylparaben Drugs 0.000 claims description 72
- 239000004322 Butylated hydroxytoluene Substances 0.000 claims description 61
- 235000010354 butylated hydroxytoluene Nutrition 0.000 claims description 61
- 229940095259 butylated hydroxytoluene Drugs 0.000 claims description 61
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 60
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 claims description 43
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims description 39
- 239000003995 emulsifying agent Substances 0.000 claims description 39
- UEUXEKPTXMALOB-UHFFFAOYSA-J tetrasodium;2-[2-[bis(carboxylatomethyl)amino]ethyl-(carboxylatomethyl)amino]acetate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]C(=O)CN(CC([O-])=O)CCN(CC([O-])=O)CC([O-])=O UEUXEKPTXMALOB-UHFFFAOYSA-J 0.000 claims description 36
- 239000002202 Polyethylene glycol Substances 0.000 claims description 35
- 229920001223 polyethylene glycol Polymers 0.000 claims description 35
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 34
- 235000021355 Stearic acid Nutrition 0.000 claims description 34
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 34
- 239000008117 stearic acid Substances 0.000 claims description 34
- 239000002253 acid Substances 0.000 claims description 33
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 33
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 claims description 32
- 229960001083 diazolidinylurea Drugs 0.000 claims description 32
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 31
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 31
- 239000007764 o/w emulsion Substances 0.000 claims description 28
- 150000002148 esters Chemical class 0.000 claims description 26
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 claims description 21
- 235000013871 bee wax Nutrition 0.000 claims description 19
- 239000012166 beeswax Substances 0.000 claims description 19
- 229940075529 glyceryl stearate Drugs 0.000 claims description 19
- 229940100460 peg-100 stearate Drugs 0.000 claims description 18
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 17
- 235000011187 glycerol Nutrition 0.000 claims description 17
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 16
- 150000002170 ethers Chemical group 0.000 claims description 15
- ODFAPIRLUPAQCQ-UHFFFAOYSA-M sodium stearoyl lactylate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O ODFAPIRLUPAQCQ-UHFFFAOYSA-M 0.000 claims description 14
- 229940080352 sodium stearoyl lactylate Drugs 0.000 claims description 14
- 229940081733 cetearyl alcohol Drugs 0.000 claims description 13
- -1 oleyl succinate Chemical compound 0.000 claims description 13
- 229940046000 sodium isostearoyl lactylate Drugs 0.000 claims description 13
- FOSNFLMXYRQNAF-UHFFFAOYSA-M sodium;2-[2-(16-methylheptadecanoyloxy)propanoyloxy]propanoate Chemical compound [Na+].CC(C)CCCCCCCCCCCCCCC(=O)OC(C)C(=O)OC(C)C([O-])=O FOSNFLMXYRQNAF-UHFFFAOYSA-M 0.000 claims description 13
- 239000011734 sodium Substances 0.000 claims description 12
- 229910052708 sodium Inorganic materials 0.000 claims description 12
- ADWNFGORSPBALY-UHFFFAOYSA-M sodium;2-[dodecyl(methyl)amino]acetate Chemical compound [Na+].CCCCCCCCCCCCN(C)CC([O-])=O ADWNFGORSPBALY-UHFFFAOYSA-M 0.000 claims description 11
- 125000004432 carbon atom Chemical group C* 0.000 claims description 10
- 229940073639 ceteareth-6 Drugs 0.000 claims description 10
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 9
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 claims description 9
- 229940083542 sodium Drugs 0.000 claims description 9
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 claims description 9
- 229940057950 sodium laureth sulfate Drugs 0.000 claims description 9
- 229940079862 sodium lauryl sarcosinate Drugs 0.000 claims description 9
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 claims description 9
- 229940086735 succinate Drugs 0.000 claims description 9
- 150000007530 organic bases Chemical class 0.000 claims description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 7
- 125000003827 glycol group Chemical group 0.000 claims description 5
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 claims description 3
- 150000007529 inorganic bases Chemical class 0.000 claims description 3
- 239000004615 ingredient Substances 0.000 abstract description 33
- 239000003963 antioxidant agent Substances 0.000 abstract description 16
- 230000003078 antioxidant effect Effects 0.000 abstract description 16
- 239000002738 chelating agent Substances 0.000 abstract description 14
- 239000012676 herbal extract Substances 0.000 abstract description 6
- 239000006071 cream Substances 0.000 description 19
- 238000002156 mixing Methods 0.000 description 19
- 238000002360 preparation method Methods 0.000 description 18
- 235000006708 antioxidants Nutrition 0.000 description 15
- 150000007524 organic acids Chemical class 0.000 description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 12
- 238000000034 method Methods 0.000 description 10
- 208000004210 Pressure Ulcer Diseases 0.000 description 7
- 239000002537 cosmetic Substances 0.000 description 7
- 230000006870 function Effects 0.000 description 7
- 229920002125 Sokalan® Polymers 0.000 description 6
- 208000017520 skin disease Diseases 0.000 description 6
- 239000002585 base Substances 0.000 description 5
- 239000000839 emulsion Substances 0.000 description 5
- 239000000820 nonprescription drug Substances 0.000 description 5
- 238000011282 treatment Methods 0.000 description 5
- KFDNQUWMBLVQNB-UHFFFAOYSA-N 2-[2-[bis(carboxymethyl)amino]ethyl-(carboxymethyl)amino]acetic acid;sodium Chemical group [Na].[Na].[Na].[Na].OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KFDNQUWMBLVQNB-UHFFFAOYSA-N 0.000 description 4
- 241000208680 Hamamelis mollis Species 0.000 description 4
- 229940089116 arnica extract Drugs 0.000 description 4
- 229940119217 chamomile extract Drugs 0.000 description 4
- 235000020221 chamomile extract Nutrition 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 229940093915 gynecological organic acid Drugs 0.000 description 4
- 235000005985 organic acids Nutrition 0.000 description 4
- 230000000475 sunscreen effect Effects 0.000 description 4
- 239000000516 sunscreening agent Substances 0.000 description 4
- 229940118846 witch hazel Drugs 0.000 description 4
- 206010056340 Diabetic ulcer Diseases 0.000 description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 3
- 206010014989 Epidermolysis bullosa Diseases 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 206010027626 Milia Diseases 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 3
- 150000007522 mineralic acids Chemical class 0.000 description 3
- OZZQHCBFUVFZGT-UHFFFAOYSA-N 2-(2-hydroxypropanoyloxy)propanoic acid Chemical compound CC(O)C(=O)OC(C)C(O)=O OZZQHCBFUVFZGT-UHFFFAOYSA-N 0.000 description 2
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- 235000017309 Hypericum perforatum Nutrition 0.000 description 2
- 244000141009 Hypericum perforatum Species 0.000 description 2
- 241000218652 Larix Species 0.000 description 2
- YBGZDTIWKVFICR-JLHYYAGUSA-N Octyl 4-methoxycinnamic acid Chemical compound CCCCC(CC)COC(=O)\C=C\C1=CC=C(OC)C=C1 YBGZDTIWKVFICR-JLHYYAGUSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229920002385 Sodium hyaluronate Polymers 0.000 description 2
- 235000020759 St. John’s wort extract Nutrition 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- 239000003513 alkali Substances 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 239000003086 colorant Substances 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 150000001261 hydroxy acids Chemical class 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 150000002632 lipids Chemical class 0.000 description 2
- 229960001679 octinoxate Drugs 0.000 description 2
- DXGLGDHPHMLXJC-UHFFFAOYSA-N oxybenzone Chemical compound OC1=CC(OC)=CC=C1C(=O)C1=CC=CC=C1 DXGLGDHPHMLXJC-UHFFFAOYSA-N 0.000 description 2
- 229960001173 oxybenzone Drugs 0.000 description 2
- 229940101267 panthenol Drugs 0.000 description 2
- 239000011619 pantothenol Substances 0.000 description 2
- 235000020957 pantothenol Nutrition 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 239000004584 polyacrylic acid Substances 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 229940010747 sodium hyaluronate Drugs 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 2
- 229940099416 st. john's wort extract Drugs 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 239000000341 volatile oil Substances 0.000 description 2
- RFIMISVNSAUMBU-UHFFFAOYSA-N 2-(hydroxymethyl)-2-(prop-2-enoxymethyl)propane-1,3-diol Chemical compound OCC(CO)(CO)COCC=C RFIMISVNSAUMBU-UHFFFAOYSA-N 0.000 description 1
- RFVNOJDQRGSOEL-UHFFFAOYSA-N 2-hydroxyethyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCO RFVNOJDQRGSOEL-UHFFFAOYSA-N 0.000 description 1
- 241000208140 Acer Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 239000003109 Disodium ethylene diamine tetraacetate Substances 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 244000068988 Glycine max Species 0.000 description 1
- 235000010469 Glycine max Nutrition 0.000 description 1
- 235000005590 Larix decidua Nutrition 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- 229920002701 Polyoxyl 40 Stearate Polymers 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 241001147416 Ursus maritimus Species 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 125000001931 aliphatic group Chemical group 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 229940086737 allyl sucrose Drugs 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 150000001991 dicarboxylic acids Chemical class 0.000 description 1
- ZBCBWPMODOFKDW-UHFFFAOYSA-N diethanolamine Chemical compound OCCNCCO ZBCBWPMODOFKDW-UHFFFAOYSA-N 0.000 description 1
- 150000007520 diprotic acids Chemical class 0.000 description 1
- 235000019301 disodium ethylene diamine tetraacetate Nutrition 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 150000002334 glycols Chemical class 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N iso-octadecanoic acid Natural products CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000002763 monocarboxylic acids Chemical class 0.000 description 1
- 150000007518 monoprotic acids Chemical class 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 125000001117 oleyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 150000003839 salts Chemical group 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 150000003628 tricarboxylic acids Chemical class 0.000 description 1
- 150000007521 triprotic acids Chemical class 0.000 description 1
- 239000002569 water oil cream Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/06—Emulsions
- A61K8/062—Oil-in-water emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Toxicology (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
L'invention concerne une composition pour la peau sous forme de crème, contenant de l'allantoïne et au moins un émulsifiant anionique ou non ionique sensiblement hydrophile et hydrosoluble. Le pH de la composition est situé entre 3 et 6, mais de préférence entre 5 et 6. La composition peut en outre comporter un polymère anionique acide. Un polymère anionique acide préféré est un polymère carboxypolyméthylène. La composition peut en outre comporter un polymère glucidique, tel que le galactoarabinan, le polygalactose ou le polyarabinose. La composition peut également comprendre d'autres ingrédients, tels que des extraits d'herbes, un composant anti-oxydant, un composant émollient, un chélateur, un solvant ou un conservateur. La composition permet de protéger la peau.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/570,120 US6531500B2 (en) | 1999-07-23 | 2000-05-12 | Methods for treatment of inflammatory diseases |
| US09/570,120 | 2000-05-12 | ||
| US09/758,781 | 2001-01-11 | ||
| US09/758,781 US6864274B2 (en) | 1999-07-23 | 2001-01-11 | Allantoin-containing skin cream |
| PCT/US2001/014899 WO2001087232A2 (fr) | 2000-05-12 | 2001-05-09 | Crème pour la peau contenant de l'allantoïne |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2408689A1 true CA2408689A1 (fr) | 2001-11-22 |
Family
ID=27075241
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002408689A Abandoned CA2408689A1 (fr) | 2000-05-12 | 2001-05-09 | Creme pour la peau contenant de l'allantoine |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1284601A4 (fr) |
| JP (1) | JP2004513068A (fr) |
| CN (1) | CN1444450A (fr) |
| AU (1) | AU2001261290A1 (fr) |
| BR (1) | BR0110773A (fr) |
| CA (1) | CA2408689A1 (fr) |
| MX (1) | MXPA02011158A (fr) |
| WO (1) | WO2001087232A2 (fr) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020054895A1 (en) | 1999-07-23 | 2002-05-09 | Alwyn Company, Inc. | Allantoin-containing skin cream |
| US6383505B1 (en) * | 2000-11-09 | 2002-05-07 | Steris Inc | Fast-acting antimicrobial lotion with enhanced efficacy |
| GB2374804B (en) * | 2001-04-26 | 2004-03-31 | Subhas Chandra Bhairo | Skin treatment cream |
| JP2009235013A (ja) * | 2008-03-28 | 2009-10-15 | Mandom Corp | 染毛剤組成物 |
| US8492360B2 (en) | 2008-06-03 | 2013-07-23 | Otsuka Pharmaceutical Co., Ltd. | Creamy O/W emulsion composition and production process thereof |
| US20140135372A1 (en) | 2010-02-02 | 2014-05-15 | Elliott Farber | Compositions and methods of treatment of inflammatory skin conditions using allantoin |
| CN102764204A (zh) * | 2012-07-19 | 2012-11-07 | 福建省梦娇兰日用化学品有限公司 | 一种温和的具有改善皮肤功能的护肤霜及其制备方法 |
| JP6232285B2 (ja) * | 2013-12-27 | 2017-11-15 | 花王株式会社 | 化粧料 |
| JP6458005B2 (ja) * | 2014-03-27 | 2019-01-23 | 株式会社コーセー | 水中油型乳化組成物 |
| CN104434686A (zh) * | 2014-12-10 | 2015-03-25 | 唯美度科技（北京）有限公司 | 一种含红加仑提取物眼霜及其制备方法 |
| CN107106435A (zh) * | 2014-12-24 | 2017-08-29 | 莱雅公司 | 化妆品冲洗式皮肤护理组合物和使用其的化妆方法 |
| JP6735587B2 (ja) * | 2016-03-25 | 2020-08-05 | 小林製薬株式会社 | 外用組成物 |
| JP6851139B2 (ja) * | 2016-03-25 | 2021-03-31 | 小林製薬株式会社 | 外用組成物 |
| US11433016B2 (en) | 2019-03-28 | 2022-09-06 | L'oreal | Cosmetic compositions for skin |
| US11207255B2 (en) | 2019-07-30 | 2021-12-28 | L'oreal | Perfluoro-free self-foaming facial cleanser composition |
| US11364190B2 (en) | 2019-07-30 | 2022-06-21 | L'oreal | Acid perfluoro-free self-foaming facial cleanser composition |
| CN111773131A (zh) * | 2020-08-13 | 2020-10-16 | 广州贝玛生物科技有限公司 | 一种含高浓度尿囊素的膏霜及其制备方法 |
| CN114522112B (zh) * | 2021-12-20 | 2023-06-27 | 广州市瑞芬化妆品有限公司 | 即时提亮物理遮瑕长效组合物及膏霜及制备方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE720891A (fr) * | 1967-11-03 | 1969-03-17 | ||
| FR2405068A1 (fr) * | 1977-10-10 | 1979-05-04 | Sauba Lab | Composition pharmaceutique destinee au traitement du dessechement cutane |
| LU83173A1 (fr) * | 1981-02-27 | 1981-06-05 | Oreal | Nouvelles compositions cosmetiques pour le traitement des cheveux et de la peau contenant une poudre resultant de la pulverisation d'au moins une plante et un agent de cohesion |
| JPS58140013A (ja) * | 1982-02-10 | 1983-08-19 | Dai Ichi Seiyaku Co Ltd | 外用剤 |
| US4707354A (en) * | 1985-06-17 | 1987-11-17 | Alpen Tau, Inc. | Mature skin treatment and protectant compositions and methods of using same |
| US4806262A (en) * | 1985-08-14 | 1989-02-21 | The Procter & Gamble Company | Nonlathering cleansing mousse with skin conditioning benefits |
| TW197375B (fr) * | 1990-11-19 | 1993-01-01 | Hayashibara Biochem Lab | |
| DE4405510A1 (de) * | 1994-02-22 | 1995-08-24 | Henkel Kgaa | Emulsionen |
| US5661170A (en) * | 1994-03-21 | 1997-08-26 | Woodward Laboratories, Inc. | Antimicrobial compositions and methods for using the same |
| AU3633295A (en) * | 1994-09-07 | 1996-03-27 | Johnson & Johnson Consumer Products, Inc. | Retinoid compositions |
| US5536502A (en) * | 1995-02-03 | 1996-07-16 | Gerit D. Mulder | Skin-tear medicament and method of use |
| BR9603084A (pt) * | 1996-07-12 | 1998-05-05 | Cosmeticos Natural Ind Com | Composição secativa em forma de emulsão para a pele |
| US5863548A (en) * | 1998-04-01 | 1999-01-26 | Isp Investments Inc. | Light stable antimicrobial product which is a silver-allantoin complex encapsulated with allantoin |
| US6309656B1 (en) * | 1998-11-27 | 2001-10-30 | Peter T. Pugliese | Cosmetic and skin protective compositions |
-
2001
- 2001-05-09 BR BR0110773-9A patent/BR0110773A/pt not_active IP Right Cessation
- 2001-05-09 JP JP2001583701A patent/JP2004513068A/ja not_active Withdrawn
- 2001-05-09 CN CN01812735A patent/CN1444450A/zh active Pending
- 2001-05-09 AU AU2001261290A patent/AU2001261290A1/en not_active Abandoned
- 2001-05-09 MX MXPA02011158A patent/MXPA02011158A/es unknown
- 2001-05-09 EP EP01935174A patent/EP1284601A4/fr not_active Withdrawn
- 2001-05-09 WO PCT/US2001/014899 patent/WO2001087232A2/fr not_active Ceased
- 2001-05-09 CA CA002408689A patent/CA2408689A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2004513068A (ja) | 2004-04-30 |
| AU2001261290A1 (en) | 2001-11-26 |
| EP1284601A4 (fr) | 2005-02-09 |
| WO2001087232A3 (fr) | 2002-03-07 |
| CN1444450A (zh) | 2003-09-24 |
| EP1284601A2 (fr) | 2003-02-26 |
| MXPA02011158A (es) | 2004-08-19 |
| WO2001087232A2 (fr) | 2001-11-22 |
| BR0110773A (pt) | 2004-03-09 |
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Legal Events
| Date | Code | Title | Description |
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| FZDE | Dead |